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Q824E8 (THIM_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:CCA_00204
OrganismChlamydophila caviae (strain GPIC) [Complete proteome] [HAMAP]
Taxonomic identifier227941 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000021502

Sites

Binding site441Substrate; via amide nitrogen By similarity
Binding site1181ATP By similarity
Binding site1661ATP By similarity
Binding site1931Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q824E8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: AD350E5415267F53

FASTA26228,765
        10         20         30         40         50         60 
MLEQMYEALQ RLRKEKPVIL NITNYVSMDF LANCFLAIGA SPIMSVSDLE LEELIGLSSA 

        70         80         90        100        110        120 
VYLNIGTLDH LFIQRSYRAV DIAIRQNKPI IFDPVGSGTT KIRTEVSHHL LAHSTIVRGN 

       130        140        150        160        170        180 
ASKILSFGDL SIKTRGVDSA NTTHDAKETA IALANECLCG CAIAVTGAVD FITDGKRSAT 

       190        200        210        220        230        240 
IELGDPLMSH VTGMGCSLTG VLAAFRSVID DSFEAARLGV EYFSLCGMLA RERCEGPGLF 

       250        260 
KAYFLDELYA ADFDRMRRYY EQ 

« Hide

References

[1]"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. expand/collapse author list , Rank R.G., Bavoil P.M., Fraser C.M.
Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GPIC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015925 Genomic DNA. Translation: AAP04955.1.
RefSeqNP_829077.1. NC_003361.3.

3D structure databases

ProteinModelPortalQ824E8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227941.CCA00204.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP04955; AAP04955; CCA_00204.
GeneID1217889.
KEGGcca:CCA00204.
PATRIC20269430. VBIChlCav107360_0214.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBCLSK392728.

Enzyme and pathway databases

BioCycCCAV227941:GH8L-218-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_CHLCV
AccessionPrimary (citable) accession number: Q824E8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways