Reviewed, UniProtKB/Swiss-Prot Q823A7 (SURE2_CHLCV)

Names and origin

Protein names

Recommended name:
    5'-nucleotidase surE 2
    EC=3.1.3.5
Alternative name(s):
    Nucleoside 5'-monophosphate phosphohydrolase 2

Gene names

Name:	surE2
Ordered Locus Names:	CCA_00519

Organism

Chlamydophila caviae [Complete proteome] [HAMAP]

Taxonomic identifier

83557 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	5'-nucleotidase surE 2 HAMAP MF_00060		PRO_0000111800
Sites
	Metal binding	19	1	Divalent metal cation By similarity
	Metal binding	20	1	Divalent metal cation By similarity
	Metal binding	52	1	Divalent metal cation By similarity
	Metal binding	110	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q823A7-1 [UniParc]. Last modified December 15, 2003. Version 2. Checksum: 8AD406DD56D7FAB6	FASTA	283	31,003
	10 20 30 40 50 60 MSELSEQCEK RLKILLTNDD GIFAPGMTLL VSNLLKADFA DLYIVAPKTE QSAKSMAMTF 70 80 90 100 110 120 HEPVILQPYD YPLPVAGAWS VSGTPVDCVR IALAYLFKDE LPDLVLSGIN RGSNAGRHVF 130 140 150 160 170 180 YSGTLGAAIE STLCGVPAVA LSQEGNFSFF QEKNFDIPEM LKSLSLYALS LPFAPHPVAL 190 200 210 220 230 240 NVNFPASNER WKGMRFVTTG PEYSCGVPHF LFCDGDSKIF KLSGGPKIVE EIPSEEWQTL 250 260 270 280 RASYIAVSPV MATTSPLATF SLEEFEQLQV GFYDFANSLG MEN

References

[1]

"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. , Rank R.G., Bavoil P.M., Fraser C.M. Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015925 Genomic DNA. Translation: AAP05262.1. Different initiation.
RefSeq	NP_829384.1.
3D structure databases
HSSP	HSSP built from PDB template 1L5X based on UniProtKB Q8ZU79.
ModBase	Search...
Genome annotation databases
GeneID	1218204.
GenomeReviews	Gene locus CCA_00519 in contig AE015925_GR.
KEGG	cca:CCA00519.
TIGR	CCA_00519.
Phylogenomic databases
HOGENOM	Q823A7.
Enzyme and pathway databases
BioCyc	CCAV227941:CCA_00519-MON.
BRENDA	3.1.3.5. 304519.
Family and domain databases
HAMAP	MF_00060. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
ProDom	PD005378. SurE. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00087. surE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE2_CHLCV

Accession

Primary (citable) accession number: Q823A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	June 16, 2009
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)