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Q822R7

- SYL_CHLCV

UniProt

Q822R7 - SYL_CHLCV

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei604 – 6041ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCAV227941:GH8L-637-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CCA_00612
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000002193: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Leucine--tRNA ligasePRO_0000151996Add
BLAST

Proteomic databases

PRIDEiQ822R7.

Interactioni

Protein-protein interaction databases

STRINGi227941.CCA00612.

Structurei

3D structure databases

ProteinModelPortaliQ822R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi601 – 6055"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q822R7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRYDPSLIEK KWQEFWKEHK SFEADEASDK PKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HLIGYTATDI VARYKRAKGY AVLHPMGWDS FGLPAEQYAV RTGTHPRETT
110 120 130 140 150
QKNIENFRKQ LSAMGFSYDE GREFATSDPD YYRWTQKLFL FLYEKGLAYM
160 170 180 190 200
ADMAVNYCPE LGTVLSNEEV ENGLSVEGGY PVERRMLRQW ILRITAYSDQ
210 220 230 240 250
LLEGLEDLDW PENVKQLQRN WIGKSEGALV RFEVNNERFL EVFTTRPDTI
260 270 280 290 300
GGVSFLVVAP EHPEVNRLIS ENQREAVESY IRAAQSKSER DRISETKVKT
310 320 330 340 350
GVFTGTYAKH PVTGADIPIW ISDYVILGYG SGVVMGVPAH DERDREFAEA
360 370 380 390 400
FSLPIYEVLD KDECCIHSNH GDFLLDGLAG QEARDYVIAY LQKKNLGEAK
410 420 430 440 450
VAYKLRDWLF SRQRYWGEPI PIIHFEDGTC RPLEDDELPL LPPEIQDYRP
460 470 480 490 500
EGFGQGPLAK VKEWVDIHDT KTNRRGRRET HTMPQWAGSC WYYLRFCDAH
510 520 530 540 550
NSQAPWSNEN ERYWMPVDLY IGGAEHAVLH LLYSRFWHRV FYEAGMVSTA
560 570 580 590 600
EPFKKLINQG LVLATSYRIP GKGYVYPEDA REDNGVWMSA SGEELEVRQE
610 620 630 640 650
KMSKSKLNGV DPQILIDEFG ADALRMYAMF SGPLDKNKLW SNQGVSGCRR
660 670 680 690 700
FLNRFYEMAT SASVQDVDDP KGMALAHRLV HRVGEDIEKM SLNTIPSSFM
710 720 730 740 750
EFINEFVKLD IYPRSALAMV VQALAPIAPH ISEELWTVLG YAPGIDAAGW
760 770 780 790 800
PKVDPKYLED TSVTFVIQVN GKLRARLDMD KATSKEDVLS LAREAVAKYL
810 820
EGKEVKKEVF VPNRLVNFVL
Length:820
Mass (Da):93,854
Last modified:June 1, 2003 - v1
Checksum:i47DBBF2B175B10E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015925 Genomic DNA. Translation: AAP05354.1.
RefSeqiNP_829476.1. NC_003361.3.
WP_011006569.1. NC_003361.3.

Genome annotation databases

EnsemblBacteriaiAAP05354; AAP05354; CCA_00612.
GeneIDi1218297.
KEGGicca:CCA00612.
PATRICi20270339. VBIChlCav107360_0657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015925 Genomic DNA. Translation: AAP05354.1 .
RefSeqi NP_829476.1. NC_003361.3.
WP_011006569.1. NC_003361.3.

3D structure databases

ProteinModelPortali Q822R7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227941.CCA00612.

Proteomic databases

PRIDEi Q822R7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP05354 ; AAP05354 ; CCA_00612 .
GeneIDi 1218297.
KEGGi cca:CCA00612.
PATRICi 20270339. VBIChlCav107360_0657.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CCAV227941:GH8L-637-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
    Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
    , Rank R.G., Bavoil P.M., Fraser C.M.
    Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GPIC.

Entry informationi

Entry nameiSYL_CHLCV
AccessioniPrimary (citable) accession number: Q822R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3