Q822R1 (PKN1_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase pkn1
EC=2.7.11.1

Gene names

Name:	pkn1
Ordered Locus Names:	CCA_00618

Organism

Chlamydophila caviae (strain GPIC) [Complete proteome] [HAMAP]

Taxonomic identifier

227941 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila › Chlamydophila caviae

Protein attributes

Sequence length	618 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Post-translational modification	Autophosphorylated on serine and threonine residues By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Caution	Gly-141 is present instead of the conserved Asp which is expected to be an active site residue.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 618	618	Serine/threonine-protein kinase pkn1		PRO_0000171186
Regions
	Domain	15 – 381	367	Protein kinase
	Nucleotide binding	21 – 29	9	ATP By similarity
Sites
	Binding site	44	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q822R1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0D0003F43DA35F79	FASTA	618	70,173
	10 20 30 40 50 60 MEGEQDIGVE FLGDYKILCY LRKGLWCQDI LAEHRFIKKR YILKLLCSEL SSSEAFMTAF 70 80 90 100 110 120 HEAIIKLATI RHPGIISIEN VSQAEGQYFL VTEEKEVPTL SLAQYLSSCS QGLSELEAKD 130 140 150 160 170 180 LICQLAEILD YAHANRLIHG GLSLDSVHID LTGQSPKVFL PELGFSFLLK DQYTQSLLRD 190 200 210 220 230 240 SSEKSSFDKL KQILLFQAPE TALGTVAEDV YAFGVIVYFL LFRQLPQGAF PLPSEAFPEY 250 260 270 280 290 300 VYDWDRLIQS CLSYAVEKRP KKLAPLLVKK TLGEQFLAAK IQCSEEDLRE IEEEPQVPSV 310 320 330 340 350 360 ANILQKVEDK IIEETSDHLE FVLVEAKSID EAMNTSVDSK EEVVAEDESY SNALQSLLIR 370 380 390 400 410 420 EPVVSRYVEE EKEEVKPQPL FTEMVFIEGG KFLRGSREGQ RDEHPVHEIF LHSFFLDIHP 430 440 450 460 470 480 VTNEQFVRYL ECSGSEQDKY YNELIRLKDS RIQRRSGKLV IEPGYAKHPV VGVTWYGASG 490 500 510 520 530 540 YASWVGKRLP TEAEWEIASC GGVTQLRYPC GEEIDKSQAN FFSSDTTPVM SYPANPYGLY 550 560 570 580 590 600 DMAGNVYEWC EDWYGYDFYE ISAQESHAPQ GPAQGVYRVL RGGCWKSLKD DLRCAHRHRN 610 NPGAVNSTYG FRCAKGVK

References

[1]

"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. , Rank R.G., Bavoil P.M., Fraser C.M. Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015925 Genomic DNA. Translation: AAP05360.1.
RefSeq	NP_829482.1. NC_003361.3.
3D structure databases
ProteinModelPortal	Q822R1.
ModBase	Search...
Protein-protein interaction databases
STRING	227941.CCA00618.
Proteomic databases
PRIDE	Q822R1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAP05360; AAP05360; CCA_00618.
GeneID	1218303.
KEGG	cca:CCA00618.
PATRIC	20270351. VBIChlCav107360_0663.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
OMA	LLIREPV.
ProtClustDB	CLSK871217.
Enzyme and pathway databases
BioCyc	CCAV227941:GH8L-625-MONOMER.
Family and domain databases
Gene3D	3.90.1580.10. 1 hit.
InterPro	IPR016187. C-type_lectin_fold. IPR005532. FGE_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF03781. FGE-sulfatase. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKN1_CHLCV

Accession

Primary (citable) accession number: Q822R1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program