Q822K5 (PKND_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase PknD
EC=2.7.11.1

Gene names

Name:	pknD
Ordered Locus Names:	CCA_00677

Organism

Chlamydophila caviae (strain GPIC) [Complete proteome] [HAMAP]

Taxonomic identifier

227941 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila › Chlamydophila caviae

Protein attributes

Sequence length	930 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Together with the serine/threonine kinase pkn1, may play a role in the specific interactions with host proteins during intracellular growth By similarity. HAMAP-Rule MF_01957
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. HAMAP-Rule MF_01957
Post-translational modification	Autophosphorylated on serine and threonine residues By similarity. HAMAP-Rule MF_01957
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP protein serine/threonine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 930	930	Serine/threonine-protein kinase PknD HAMAP-Rule MF_01957		PRO_0000171190
Regions
	Domain	4 – 291	288	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	138	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q822K5 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 37A2451522D344C1	FASTA	930	106,618
	10 20 30 40 50 60 MQRYDIIRMI GKGGMGEVYL AYDPVCSRKV ALKRIREDLS DNELLKKRFL REAKIAADLV 70 80 90 100 110 120 HPGVVPVFTI CSDSDPVYYT MPYIEGYTLK SLLKSVWQCD SLPKDLAEQT SVATFLSIFH 130 140 150 160 170 180 KICSTVEYVH SRGILHRDLK PDNILLGLFS EVVILDWGAA LSKEMEEDFL SDIDVRIPGS 190 200 210 220 230 240 LFSNMTIPGK IVGTPDYMAP ERLRGTPASE STDIYALGVI LYQMLTLSFP YRKKKGQKIS 250 260 270 280 290 300 LRHQISFPEE IAPHREIPPF LSQVVMRALA ADPRERYRSV SALKADIEQH LQGSPEWTPK 310 320 330 340 350 360 IVLHTQDREC WKFHEPILLS KYFPMLEVSP ALWYSLAISK IESFSEVRLE YTLLRKGLEE 370 380 390 400 410 420 GFGILLPPSE GVDHGDFYHG YGFWLHIKEN ILSVSLVKNG LEIQKTSRHI DGNKEKFFIA 430 440 450 460 470 480 FEKQNHRLSL IIDNIVWTIH MDYLPARGGR IGVIIQDVAD VCGNIVVLES SGSLQVSCLA 490 500 510 520 530 540 VPDAFLNEKL YERAITFYRR IVESFPGRKE GYEAQFRIGI ALLEKASENS DSEGFIQALE 550 560 570 580 590 600 EFSTLHNSVA APLEYLGKAL VYQRLGEYNE EVKSLLLALK RYCQRPEISR VRDHVVYRLH 610 620 630 640 650 660 EALYSNHRIS LVFMLLALHV APESINASEE EHFLQNLHGK IQDTLFCNLD ISPVDFRSSK 670 680 690 700 710 720 MELLLSYWSG FTPFLLGLFQ RSWDLKDYRA LADIFYTAAD LGNKEFIEEY SGILRENIRT 730 740 750 760 770 780 TTFSKEIVEI LPDQLLCFLS GLEALTLQES IEKVFDGIEN LDPVLILYLF DLFAKDALIH 790 800 810 820 830 840 GRGEEILKAI ALVEKYISPQ QRYRYLLPYE VLSYLWMKDA NKVYDLLSSY DESSWIDDSS 850 860 870 880 890 900 HAFVLYGYWL ALAEDSSLAY LHLSGCREDS VFPRALIGVF CSPLGICEEQ LSYQERRQLL 910 920 930 LQKFIFFHCL GNSEERDKCR TAYDSKERSL

References

[1]

"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. , Rank R.G., Bavoil P.M., Fraser C.M. Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015925 Genomic DNA. Translation: AAP05419.1.
RefSeq	NP_829541.1. NC_003361.3.
3D structure databases
ProteinModelPortal	Q822K5.
ModBase	Search...
Protein-protein interaction databases
STRING	227941.CCA00677.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAP05419; AAP05419; CCA_00677.
GeneID	1218362.
KEGG	cca:CCA00677.
PATRIC	20270467. VBIChlCav107360_0720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
KO	K08884.
OMA	YQMLTLS.
ProtClustDB	PRK13184.
Enzyme and pathway databases
BioCyc	CCAV227941:GH8L-684-MONOMER.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
HAMAP	MF_01957. PknD_kinase.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR023507. Ser/Thr_kinase_PknD. IPR011990. TPR-like_helical. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKND_CHLCV

Accession

Primary (citable) accession number: Q822K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program