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Protein

Translation initiation factor IF-1

Gene

infA

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor, RNA-binding, rRNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-1UniRule annotation
Gene namesi
Name:infAUniRule annotation
Ordered Locus Names:CCA_00699
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000002193 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000957681 – 73Translation initiation factor IF-1Add BLAST73

Interactioni

Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.UniRule annotation

Protein-protein interaction databases

STRINGi227941.CCA00699.

Structurei

3D structure databases

ProteinModelPortaliQ822I3.
SMRiQ822I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73S1-likeUniRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the IF-1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K9U. Bacteria.
COG0361. LUCA.
KOiK02518.
OMAiAHVSGKM.
OrthoDBiPOG091H019C.

Family and domain databases

CDDicd04451. S1_IF1. 1 hit.
HAMAPiMF_00075. IF_1. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR022967. S1_dom.
IPR004368. TIF_IF1.
PfamiView protein in Pfam
PF01176. eIF-1a. 1 hit.
SMARTiView protein in SMART
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00008. infA. 1 hit.
PROSITEiView protein in PROSITE
PS50832. S1_IF1_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q822I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKEDTIVL EGRVQELLPG MHFKILLENG MPVTAHLCGK MRMSNIRLLV
60 70
GDRVTVEMSA YDLTKARVVY RHR
Length:73
Mass (Da):8,368
Last modified:June 1, 2003 - v1
Checksum:i7B835725C2C83B23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015925 Genomic DNA. Translation: AAP05441.1.
RefSeqiWP_006343365.1. NC_003361.3.

Genome annotation databases

EnsemblBacteriaiAAP05441; AAP05441; CCA_00699.
GeneIDi12243156.
KEGGicca:CCA_00699.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIF1_CHLCV
AccessioniPrimary (citable) accession number: Q822I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families