Reviewed, UniProtKB/Swiss-Prot Q822G7 (DAPB_CHLCV)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	CCA_00715

Organism

Chlamydophila caviae [Complete proteome] [HAMAP]

Taxonomic identifier

83557 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Dihydrodipicolinate reductase		PRO_0000141426

Sequences

	Sequence		Length	Mass (Da)
	Q822G7-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 8D70D9050278287B	FASTA	246	26,756
	10 20 30 40 50 60 MRVGIIGCSG RMGTLLSNLL RATARFTLGP GFSRTSTHSL ASVIDNNDVL VDFSSSSLSE 70 80 90 100 110 120 ELFRALLSNP KPLIFATTKP APSSSIDEKI EDLAAYVPVV VCPNTSLGAY VQKRLAALLA 130 140 150 160 170 180 AVFDDAYDIR ITEVHHRGKK DAISGTANEL VSILCDAKKK EWQQEYRVGA DSDSVKNIEL 190 200 210 220 230 240 HASRVGNISG EHEIAFISDK EQITLRHTVF SREVFAEGVL RILDWLLNES PPPGCYGPEV GLKVSV

References

[1]

"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. , Rank R.G., Bavoil P.M., Fraser C.M. Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015925 Genomic DNA. Translation: AAP05457.1.
RefSeq	NP_829579.1.
3D structure databases
HSSP	HSSP built from PDB template 1DRW based on UniProtKB P04036.
ModBase	Search...
Genome annotation databases
GeneID	1218400.
GenomeReviews	Gene locus CCA_00715 in contig AE015925_GR.
KEGG	cca:CCA00715.
TIGR	CCA_00715.
Phylogenomic databases
HOGENOM	Q822G7.
Enzyme and pathway databases
BioCyc	CCAV227941:CCA_00715-MON.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. [Graphical view]
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_CHLCV

Accession

Primary (citable) accession number: Q822G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	June 1, 2003
Last modified:	November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)