Q822F3 (AAXB_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvoyl-dependent arginine decarboxylase AaxB
Short name=PvlArgDC
EC=4.1.1.19

Alternative name(s):
Biodegradative arginine decarboxylase

Cleaved into the following 2 chains:

1. Pyruvoyl-dependent arginine decarboxylase subunit beta
2. Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	aaxB
Ordered Locus Names:	CCA_00730

Organism

Chlamydophila caviae [Complete proteome] [HAMAP]

Taxonomic identifier

83557 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the AaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response By similarity.
Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyruvoyl group By similarity.
Subunit structure	Trimer of an alpha-beta dimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyruvoyl-dependent arginine decarboxylase family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 52	52	Pyruvoyl-dependent arginine decarboxylase subunit beta		PRO_0000364039
	Chain	53 – 195	143	Pyruvoyl-dependent arginine decarboxylase subunit alpha		PRO_0000364040
Sites
	Site	52 – 53	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	53	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q822F3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: BD1D5CDC01D351C5	FASTA	195	21,775
	10 20 30 40 50 60 MPYGTRYPTL AFHTGGIGES DDGMPPQPFE TFCYDSALLQ AKIENFNIVP YTSVLPKELF 70 80 90 100 110 120 GNIVPVDQCI KFFKHGAVLE VIMAGRGAST SDGTHAIATG VGICWGQDKN GELIGGWAAE 130 140 150 160 170 180 YVEFFPTWIN DEIAESHAKM WLKKSLQHEL DLRSVVKHSE FQYFHNYINI KQKYGFSLTA 190 LGFLNFENAD PATIK

References

[1]

"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. , Rank R.G., Bavoil P.M., Fraser C.M. Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015925 Genomic DNA. Translation: AAP05471.1.
RefSeq	NP_829593.1. NC_003361.3.
3D structure databases
ProteinModelPortal	Q822F3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1218415.
GenomeReviews	Gene locus CCA_00730 in contig AE015925_GR.
KEGG	cca:CCA00730.
PATRIC	20270583. VBIChlCav107360_0775.
TIGR	CCA_00730.
Phylogenomic databases
HOGENOM	HBG414056.
OMA	WIDDEIA.
ProtClustDB	CLSK403032.
Enzyme and pathway databases
BioCyc	CCAV227941:CCA_00730-MONOMER.
Family and domain databases
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56271. His_carbxylase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AAXB_CHLCV

Accession

Primary (citable) accession number: Q822F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program