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Q822E9 (MDH_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase
EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:CCA_00734
OrganismChlamydophila caviae [Complete proteome] [HAMAP]
Taxonomic identifier83557 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517

Subunit structure

Homodimer By similarity. HAMAP MF_01517

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Malate dehydrogenase HAMAP MF_01517
PRO_0000113356

Regions

Nucleotide binding15 – 217NAD By similarity
Nucleotide binding133 – 1353NAD By similarity

Sites

Active site1911Proton acceptor By similarity
Binding site961Substrate By similarity
Binding site1021Substrate By similarity
Binding site1091NAD By similarity
Binding site1161NAD By similarity
Binding site1351Substrate By similarity
Binding site1661Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q822E9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: D3E0544E1146AD5C

FASTA33036,083
        10         20         30         40         50         60 
MIMKLMRTVS VAVTGGTGQI AYSFLFALAH GDVFGSDCSI DLRVYDLPGL ERALSGVRME 

        70         80         90        100        110        120 
LDDCAYPLLQ SLRVTTSLED ACDGIDAAFL IGAAPRGPGM ERSDLLKRNG EIFSLQGSVL 

       130        140        150        160        170        180 
NVCAKRDAKI FVVGNPVNTN CWIAMNKAPK LNRRNFHSML RLDQNRMHTM LAHRAEVPLD 

       190        200        210        220        230        240 
EVTNVVVWGN HSAKQVPDFT QALISGKPAV EVISDRDWLE NIMFPSIQNR GSAVIEARGK 

       250        260        270        280        290        300 
SSAGSAARAL AEAARSIFLP KDGEWFSSGV CSDYNPYGIP DDLIFGFPCR MLPSGDYEIV 

       310        320        330 
PGLPWDAFIK NKIQISLDEI SQEKASVSLL

« Hide

References

[1]"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. expand/collapse author list , Rank R.G., Bavoil P.M., Fraser C.M.
Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GPIC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015925 Genomic DNA. Translation: AAP05475.1.
RefSeqNP_829597.1. NC_003361.3.

3D structure databases

ProteinModelPortalQ822E9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1218419.
GenomeReviewsGene locus CCA_00734 in contig AE015925_GR.
KEGGcca:CCA00734.
PATRIC20270593. VBIChlCav107360_0780.
TIGRCCA_00734.

Phylogenomic databases

HOGENOMHBG289884.
OMANKIQISL.
ProtClustDBPRK05442.

Enzyme and pathway databases

BioCycCCAV227941:CCA_00734-MONOMER.

Family and domain databases

HAMAPMF_01517. Malate_dehydrog_2.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00024.
PANTHERPTHR23382. MDH_SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_CHLCV
AccessionPrimary (citable) accession number: Q822E9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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