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Q822E9

- MDH_CHLCV

UniProt

Q822E9 - MDH_CHLCV

Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961SubstrateUniRule annotation
    Binding sitei102 – 1021SubstrateUniRule annotation
    Binding sitei109 – 1091NADUniRule annotation
    Binding sitei116 – 1161NADUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Active sitei191 – 1911Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 217NADUniRule annotation
    Nucleotide bindingi133 – 1353NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCCAV227941:GH8L-763-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:CCA_00734
    OrganismiChlamydophila caviae (strain GPIC)
    Taxonomic identifieri227941 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000002193: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Malate dehydrogenasePRO_0000113356Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227941.CCA00734.

    Structurei

    3D structure databases

    ProteinModelPortaliQ822E9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    KOiK00024.
    OMAiAFSQECI.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q822E9-1 [UniParc]FASTAAdd to Basket

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    MIMKLMRTVS VAVTGGTGQI AYSFLFALAH GDVFGSDCSI DLRVYDLPGL    50
    ERALSGVRME LDDCAYPLLQ SLRVTTSLED ACDGIDAAFL IGAAPRGPGM 100
    ERSDLLKRNG EIFSLQGSVL NVCAKRDAKI FVVGNPVNTN CWIAMNKAPK 150
    LNRRNFHSML RLDQNRMHTM LAHRAEVPLD EVTNVVVWGN HSAKQVPDFT 200
    QALISGKPAV EVISDRDWLE NIMFPSIQNR GSAVIEARGK SSAGSAARAL 250
    AEAARSIFLP KDGEWFSSGV CSDYNPYGIP DDLIFGFPCR MLPSGDYEIV 300
    PGLPWDAFIK NKIQISLDEI SQEKASVSLL 330
    Length:330
    Mass (Da):36,083
    Last modified:June 1, 2003 - v1
    Checksum:iD3E0544E1146AD5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05475.1.
    RefSeqiNP_829597.1. NC_003361.3.
    WP_011006689.1. NC_003361.3.

    Genome annotation databases

    EnsemblBacteriaiAAP05475; AAP05475; CCA_00734.
    GeneIDi1218419.
    KEGGicca:CCA00734.
    PATRICi20270593. VBIChlCav107360_0780.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05475.1 .
    RefSeqi NP_829597.1. NC_003361.3.
    WP_011006689.1. NC_003361.3.

    3D structure databases

    ProteinModelPortali Q822E9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227941.CCA00734.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP05475 ; AAP05475 ; CCA_00734 .
    GeneIDi 1218419.
    KEGGi cca:CCA00734.
    PATRICi 20270593. VBIChlCav107360_0780.

    Phylogenomic databases

    eggNOGi COG0039.
    KOi K00024.
    OMAi AFSQECI.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci CCAV227941:GH8L-763-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
      Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
      , Rank R.G., Bavoil P.M., Fraser C.M.
      Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GPIC.

    Entry informationi

    Entry nameiMDH_CHLCV
    AccessioniPrimary (citable) accession number: Q822E9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3