Q822E9 (MDH_CHLCV) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 67.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Malate dehydrogenase EC=1.1.1.37 | ||||
| Gene names |
| ||||
| Organism | Chlamydophila caviae [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83557 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila |
Protein attributes
| Sequence length | 330 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517 |
| Catalytic activity | (S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517 |
| Subunit structure | Homodimer By similarity. HAMAP MF_01517 |
| Sequence similarities | Belongs to the LDH/MDH superfamily. MDH type 2 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic processInferred from electronic annotation. Source: InterPro tricarboxylic acid cycleInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 330 | 330 | Malate dehydrogenase HAMAP MF_01517 | PRO_0000113356 | |||||
Regions | |||||||||
| Nucleotide binding | 15 – 21 | 7 | NAD By similarity | ||||||
| Nucleotide binding | 133 – 135 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 191 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 96 | 1 | Substrate By similarity | ||||||
| Binding site | 102 | 1 | Substrate By similarity | ||||||
| Binding site | 109 | 1 | NAD By similarity | ||||||
| Binding site | 116 | 1 | NAD By similarity | ||||||
| Binding site | 135 | 1 | Substrate By similarity | ||||||
| Binding site | 166 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. Fraser C.M.Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE015925 Genomic DNA. Translation: AAP05475.1. |
| RefSeq | NP_829597.1. NC_003361.3. |
3D structure databases | |
| ProteinModelPortal | Q822E9. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1218419. |
| GenomeReviews | Gene locus CCA_00734 in contig AE015925_GR. |
| KEGG | cca:CCA00734. |
| PATRIC | 20270593. VBIChlCav107360_0780. |
| TIGR | CCA_00734. |
Phylogenomic databases | |
| HOGENOM | HBG289884. |
| OMA | NKIQISL. |
| ProtClustDB | PRK05442. |
Enzyme and pathway databases | |
| BioCyc | CCAV227941:CCA_00734-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01517. Malate_dehydrog_2. [Tree] |
| InterPro | IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR010945. Malate_DH_type2. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K00024. |
| PANTHER | PTHR23382. MDH_SF1. 1 hit. |
| Pfam | PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000102. Lac_mal_DH. 1 hit. |
| SUPFAM | SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit. |
| TIGRFAMs | TIGR01759. MalateDH-SF1. 1 hit. |
| PROSITE | PS00068. MDH. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDH_CHLCV | ||||||||
| Accession | Primary (citable) accession number: Q822E9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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