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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei604For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:CCA_00788
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000002193 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353172 – 609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST608

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227941.CCA00788.

Structurei

3D structure databases

ProteinModelPortaliQ821Z7.
SMRiQ821Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 219Glutamine amidotransferase type-2UniRule annotationAdd BLAST218
Domaini280 – 426SIS 1UniRule annotationAdd BLAST147
Domaini458 – 599SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiASEYRYA.
OrthoDBiPOG091H0061.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF15. PTHR10937:SF15. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q821Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIFGYIGA KLAVPVVLDG LAKLEYRGYD SAGLAAVIPE RLFVRKTVGR
60 70 80 90 100
VDELRSSLEK ENVPSSLAIG HTRWATHGVP TVKNAHPHVD ENSACAIVHN
110 120 130 140 150
GIIDNFKELR SLLISEGISF SSDTDSEVIA QLFAFRYQAT GDLVHSFSWT
160 170 180 190 200
LSQLQGSFSC GLIHKDHPNV LLCAAQESPL IIGLGEKESF IASDARAFLK
210 220 230 240 250
HTKSIQALAS GELAVVGLGS EVETYNFALK RIHKEVRQVV YTDADSDKQG
260 270 280 290 300
YSYYMLKEIY EQPEVLERLI HKYLDQQGCI SEKFLNGFSI EDFDEISIVA
310 320 330 340 350
CGSSYHAGFL AKYIIESLVS IPVHVEVASE FRYRQAYIGK KTLAILISQS
360 370 380 390 400
GETADTLAAL KEFRRRQVAC VLGICNVEES ALATGVDHCL FLEAGIEIGV
410 420 430 440 450
ASTKAFTAQL LLLILLGLKL ATLKQTLSLE EHRACGKGLF ELPELCNRLL
460 470 480 490 500
ANENLHSWAN DYCDEDRFIF LGRRLMYPIC MEAALKLKEI AYVEANCYPA
510 520 530 540 550
GEMKHGPIAL ISQGSPVITF CGDPVVYEKM VGCIMEVKAR QAHVIAVASE
560 570 580 590 600
SQEDIAAVSD AQIYVPNSHP LVSPILYTIV GQIMAYTMAL KKGYEIDRPR

NLAKSVTVE
Length:609
Mass (Da):67,025
Last modified:January 23, 2007 - v3
Checksum:i875C07615FF49A88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015925 Genomic DNA. Translation: AAP05529.1.
RefSeqiWP_011006743.1. NC_003361.3.

Genome annotation databases

EnsemblBacteriaiAAP05529; AAP05529; CCA_00788.
KEGGicca:CCA_00788.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGLMS_CHLCV
AccessioniPrimary (citable) accession number: Q821Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome