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Q821Z3 (LPXB_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:CCA_00792
OrganismChlamydophila caviae (strain GPIC) [Complete proteome] [HAMAP]
Taxonomic identifier227941 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

In the C-terminal section; belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 626626Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190158

Regions

Region1 – 225225Unknown HAMAP-Rule MF_00392
Region226 – 626401Lipid-A-disaccharide synthase HAMAP-Rule MF_00392

Sequences

Sequence LengthMass (Da)Tools
Q821Z3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 61DEC1BED06E1B38

FASTA62671,491
        10         20         30         40         50         60 
MLPLYLVHVL YPIGLIANLF FGSAFTIQWL LSEKRKTAYV PKAFWVLSSI GAVMMIAHGF 

        70         80         90        100        110        120 
IQSQFPMALL HGANLVIYFR NLNIASSYKL SLTTTLVILV LTLLVTTLPF ALAAYYYPYM 

       130        140        150        160        170        180 
EWMASPNFFH LPLPPPNIYW HIVGCLGLFT FSSRFFIQWC YLEMNNHSTL PALFWQAGFV 

       190        200        210        220        230        240 
GGFLAFIYFI RTGDPVNILS YGCGLLPSLA NLRIIYKKSR LPKFHSPSCF LSAGEPSGDT 

       250        260        270        280        290        300 
LGSDLLRNIK ELNPNIHCFG VGGPLMRKEG LEPLIRMEEF QVSGFLEVFC AVFSLYKKYR 

       310        320        330        340        350        360 
KLYKAILKEN PETVFCIDFP DFHFFLIRKL RKCGYRGKII HYVCPSIWAW RPNRKKILEK 

       370        380        390        400        410        420 
HLDTLLLILP FEKEIFKDSP LKTIYLGHPL VKTIANFQDC NAWKQQLEIS DQPSVALFPG 

       430        440        450        460        470        480 
SRPGDIFRNL QVQARAFRSS SLAKSHQLLV SSCNPKYDKK ILELLDKEGC HNNKIVPSKF 

       490        500        510        520        530        540 
RYQLMRDCDC ALAKCGTIVL EAALNQTPTI VTCLLRPFDT FLAKYIFKIF IPAYSLPNII 

       550        560        570        580        590        600 
TGSVIFPEFI GGKHDFSPEE VAAAIDILAN PIGKEKQKYA CQQLLKTMTE NVITPKECLQ 

       610        620 
AIYAQKNRFY LKNDFIKEFH PKSSRA 

« Hide

References

[1]"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. expand/collapse author list , Rank R.G., Bavoil P.M., Fraser C.M.
Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GPIC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015925 Genomic DNA. Translation: AAP05533.1.
RefSeqNP_829655.1. NC_003361.3.

3D structure databases

ProteinModelPortalQ821Z3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227941.CCA00792.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP05533; AAP05533; CCA_00792.
GeneID1218477.
KEGGcca:CCA00792.
PATRIC20270715. VBIChlCav107360_0838.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3952.
KOK00748.
OMAKIIHYVC.
OrthoDBEOG6FBWZR.
ProtClustDBPRK01021.

Enzyme and pathway databases

BioCycCCAV227941:GH8L-824-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_CHLCV
AccessionPrimary (citable) accession number: Q821Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways