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Q821Z3

- LPXB_CHLCV

UniProt

Q821Z3 - LPXB_CHLCV

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, CCA_00792
Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCCAV227941:GH8L-824-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CCA_00792
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000002193: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Lipid-A-disaccharide synthaseUniRule annotationPRO_0000190158Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227941.CCA00792.

Structurei

3D structure databases

ProteinModelPortaliQ821Z3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 225225UnknownUniRule annotationAdd
BLAST
Regioni226 – 626401Lipid-A-disaccharide synthaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG3952.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q821Z3-1 [UniParc]FASTAAdd to Basket

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MLPLYLVHVL YPIGLIANLF FGSAFTIQWL LSEKRKTAYV PKAFWVLSSI    50
GAVMMIAHGF IQSQFPMALL HGANLVIYFR NLNIASSYKL SLTTTLVILV 100
LTLLVTTLPF ALAAYYYPYM EWMASPNFFH LPLPPPNIYW HIVGCLGLFT 150
FSSRFFIQWC YLEMNNHSTL PALFWQAGFV GGFLAFIYFI RTGDPVNILS 200
YGCGLLPSLA NLRIIYKKSR LPKFHSPSCF LSAGEPSGDT LGSDLLRNIK 250
ELNPNIHCFG VGGPLMRKEG LEPLIRMEEF QVSGFLEVFC AVFSLYKKYR 300
KLYKAILKEN PETVFCIDFP DFHFFLIRKL RKCGYRGKII HYVCPSIWAW 350
RPNRKKILEK HLDTLLLILP FEKEIFKDSP LKTIYLGHPL VKTIANFQDC 400
NAWKQQLEIS DQPSVALFPG SRPGDIFRNL QVQARAFRSS SLAKSHQLLV 450
SSCNPKYDKK ILELLDKEGC HNNKIVPSKF RYQLMRDCDC ALAKCGTIVL 500
EAALNQTPTI VTCLLRPFDT FLAKYIFKIF IPAYSLPNII TGSVIFPEFI 550
GGKHDFSPEE VAAAIDILAN PIGKEKQKYA CQQLLKTMTE NVITPKECLQ 600
AIYAQKNRFY LKNDFIKEFH PKSSRA 626
Length:626
Mass (Da):71,491
Last modified:June 1, 2003 - v1
Checksum:i61DEC1BED06E1B38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015925 Genomic DNA. Translation: AAP05533.1.
RefSeqiNP_829655.1. NC_003361.3.
WP_011006747.1. NC_003361.3.

Genome annotation databases

EnsemblBacteriaiAAP05533; AAP05533; CCA_00792.
GeneIDi1218477.
KEGGicca:CCA00792.
PATRICi20270715. VBIChlCav107360_0838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015925 Genomic DNA. Translation: AAP05533.1 .
RefSeqi NP_829655.1. NC_003361.3.
WP_011006747.1. NC_003361.3.

3D structure databases

ProteinModelPortali Q821Z3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227941.CCA00792.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP05533 ; AAP05533 ; CCA_00792 .
GeneIDi 1218477.
KEGGi cca:CCA00792.
PATRICi 20270715. VBIChlCav107360_0838.

Phylogenomic databases

eggNOGi COG3952.
KOi K00748.
OMAi KIIHYVC.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CCAV227941:GH8L-824-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view ]
Pfami PF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view ]
ProDomi PD339292. LAB_N. 2 hits.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
    Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
    , Rank R.G., Bavoil P.M., Fraser C.M.
    Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GPIC.

Entry informationi

Entry nameiLPXB_CHLCV
AccessioniPrimary (citable) accession number: Q821Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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