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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCCAV227941:GH8L-824-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CCA_00792
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000002193 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Lipid-A-disaccharide synthasePRO_0000190158Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227941.CCA00792.

Structurei

3D structure databases

ProteinModelPortaliQ821Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 225225UnknownAdd
BLAST
Regioni226 – 626401Lipid-A-disaccharide synthaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG3952.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q821Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLYLVHVL YPIGLIANLF FGSAFTIQWL LSEKRKTAYV PKAFWVLSSI
60 70 80 90 100
GAVMMIAHGF IQSQFPMALL HGANLVIYFR NLNIASSYKL SLTTTLVILV
110 120 130 140 150
LTLLVTTLPF ALAAYYYPYM EWMASPNFFH LPLPPPNIYW HIVGCLGLFT
160 170 180 190 200
FSSRFFIQWC YLEMNNHSTL PALFWQAGFV GGFLAFIYFI RTGDPVNILS
210 220 230 240 250
YGCGLLPSLA NLRIIYKKSR LPKFHSPSCF LSAGEPSGDT LGSDLLRNIK
260 270 280 290 300
ELNPNIHCFG VGGPLMRKEG LEPLIRMEEF QVSGFLEVFC AVFSLYKKYR
310 320 330 340 350
KLYKAILKEN PETVFCIDFP DFHFFLIRKL RKCGYRGKII HYVCPSIWAW
360 370 380 390 400
RPNRKKILEK HLDTLLLILP FEKEIFKDSP LKTIYLGHPL VKTIANFQDC
410 420 430 440 450
NAWKQQLEIS DQPSVALFPG SRPGDIFRNL QVQARAFRSS SLAKSHQLLV
460 470 480 490 500
SSCNPKYDKK ILELLDKEGC HNNKIVPSKF RYQLMRDCDC ALAKCGTIVL
510 520 530 540 550
EAALNQTPTI VTCLLRPFDT FLAKYIFKIF IPAYSLPNII TGSVIFPEFI
560 570 580 590 600
GGKHDFSPEE VAAAIDILAN PIGKEKQKYA CQQLLKTMTE NVITPKECLQ
610 620
AIYAQKNRFY LKNDFIKEFH PKSSRA
Length:626
Mass (Da):71,491
Last modified:June 1, 2003 - v1
Checksum:i61DEC1BED06E1B38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015925 Genomic DNA. Translation: AAP05533.1.
RefSeqiNP_829655.1. NC_003361.3.

Genome annotation databases

EnsemblBacteriaiAAP05533; AAP05533; CCA_00792.
KEGGicca:CCA00792.
PATRICi20270715. VBIChlCav107360_0838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015925 Genomic DNA. Translation: AAP05533.1.
RefSeqiNP_829655.1. NC_003361.3.

3D structure databases

ProteinModelPortaliQ821Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227941.CCA00792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP05533; AAP05533; CCA_00792.
KEGGicca:CCA00792.
PATRICi20270715. VBIChlCav107360_0838.

Phylogenomic databases

eggNOGiCOG3952.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciCCAV227941:GH8L-824-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
    Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
    , Rank R.G., Bavoil P.M., Fraser C.M.
    Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GPIC.

Entry informationi

Entry nameiLPXB_CHLCV
AccessioniPrimary (citable) accession number: Q821Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.