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Q821Z3

- LPXB_CHLCV

UniProt

Q821Z3 - LPXB_CHLCV

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCCAV227941:GH8L-824-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:CCA_00792
    OrganismiChlamydophila caviae (strain GPIC)
    Taxonomic identifieri227941 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000002193: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 626626Lipid-A-disaccharide synthasePRO_0000190158Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227941.CCA00792.

    Structurei

    3D structure databases

    ProteinModelPortaliQ821Z3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 225225UnknownAdd
    BLAST
    Regioni226 – 626401Lipid-A-disaccharide synthaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG3952.
    KOiK00748.
    OMAiKIIHYVC.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view]
    PfamiPF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view]
    ProDomiPD339292. LAB_N. 2 hits.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q821Z3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPLYLVHVL YPIGLIANLF FGSAFTIQWL LSEKRKTAYV PKAFWVLSSI    50
    GAVMMIAHGF IQSQFPMALL HGANLVIYFR NLNIASSYKL SLTTTLVILV 100
    LTLLVTTLPF ALAAYYYPYM EWMASPNFFH LPLPPPNIYW HIVGCLGLFT 150
    FSSRFFIQWC YLEMNNHSTL PALFWQAGFV GGFLAFIYFI RTGDPVNILS 200
    YGCGLLPSLA NLRIIYKKSR LPKFHSPSCF LSAGEPSGDT LGSDLLRNIK 250
    ELNPNIHCFG VGGPLMRKEG LEPLIRMEEF QVSGFLEVFC AVFSLYKKYR 300
    KLYKAILKEN PETVFCIDFP DFHFFLIRKL RKCGYRGKII HYVCPSIWAW 350
    RPNRKKILEK HLDTLLLILP FEKEIFKDSP LKTIYLGHPL VKTIANFQDC 400
    NAWKQQLEIS DQPSVALFPG SRPGDIFRNL QVQARAFRSS SLAKSHQLLV 450
    SSCNPKYDKK ILELLDKEGC HNNKIVPSKF RYQLMRDCDC ALAKCGTIVL 500
    EAALNQTPTI VTCLLRPFDT FLAKYIFKIF IPAYSLPNII TGSVIFPEFI 550
    GGKHDFSPEE VAAAIDILAN PIGKEKQKYA CQQLLKTMTE NVITPKECLQ 600
    AIYAQKNRFY LKNDFIKEFH PKSSRA 626
    Length:626
    Mass (Da):71,491
    Last modified:June 1, 2003 - v1
    Checksum:i61DEC1BED06E1B38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05533.1.
    RefSeqiNP_829655.1. NC_003361.3.
    WP_011006747.1. NC_003361.3.

    Genome annotation databases

    EnsemblBacteriaiAAP05533; AAP05533; CCA_00792.
    GeneIDi1218477.
    KEGGicca:CCA00792.
    PATRICi20270715. VBIChlCav107360_0838.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05533.1 .
    RefSeqi NP_829655.1. NC_003361.3.
    WP_011006747.1. NC_003361.3.

    3D structure databases

    ProteinModelPortali Q821Z3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227941.CCA00792.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP05533 ; AAP05533 ; CCA_00792 .
    GeneIDi 1218477.
    KEGGi cca:CCA00792.
    PATRICi 20270715. VBIChlCav107360_0838.

    Phylogenomic databases

    eggNOGi COG3952.
    KOi K00748.
    OMAi KIIHYVC.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci CCAV227941:GH8L-824-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view ]
    Pfami PF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view ]
    ProDomi PD339292. LAB_N. 2 hits.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
      Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
      , Rank R.G., Bavoil P.M., Fraser C.M.
      Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GPIC.

    Entry informationi

    Entry nameiLPXB_CHLCV
    AccessioniPrimary (citable) accession number: Q821Z3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3