Reviewed,
UniProtKB/Swiss-Prot Q821S4 (MUDD_CHLCV)
Last modified
February 9, 2010.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional enzyme murC/ddl Including the following 2 domains: 1- Recommended name: UDP-N-acetylmuramate--L-alanine ligase EC=6.3.2.8 Alternative name(s): UDP-N-acetylmuramoyl-L-alanine synthetase 2- Recommended name: D-alanine--D-alanine ligase EC=6.3.2.4 Alternative name(s): D-alanylalanine synthetase D-Ala-D-Ala ligase | ||||
| Gene names |
| ||||
| Organism | Chlamydophila caviae [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83557 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila |
Protein attributes
| Sequence length | 811 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046 ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP MF_00046 |
| Cofactor | Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP MF_00046 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046 |
| Subcellular location | Cytoplasm Probable HAMAP MF_00046. |
| Sequence similarities | In the N-terminal section; belongs to the murCDEF family. In the C-terminal section; belongs to the D-alanine--D-alanine ligase family. Contains 1 ATP-grasp domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 811 | 811 | Bifunctional enzyme murC/ddl HAMAP MF_00046 | PRO_0000177913 | |||||
Regions | |||||||||
| Domain | 574 – 785 | 212 | ATP-grasp | ||||||
| Nucleotide binding | 111 – 117 | 7 | ATP Potential | ||||||
| Nucleotide binding | 607 – 662 | 56 | ATP By similarity | ||||||
| Region | 1 – 450 | 450 | UDP-N-acetylmuramate--alanine ligase HAMAP MF_00046 | ||||||
| Region | 451 – 811 | 361 | D-alanine--D-alanine ligase HAMAP MF_00046 | ||||||
Sites | |||||||||
| Metal binding | 739 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 752 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 752 | 1 | Magnesium or manganese 2 By similarity | ||||||
| Metal binding | 754 | 1 | Magnesium or manganese 2 By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. Fraser C.M.Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE015925 Genomic DNA. Translation: AAP05604.1. |
| RefSeq | NP_829726.1. |
3D structure databases | |
| SMR | Q821S4. Positions 5-446, 451-803. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1218548. |
| GenomeReviews | Gene locus CCA_00863 in contig AE015925_GR. |
| KEGG | cca:CCA00863. |
| TIGR | CCA_00863. |
Phylogenomic databases | |
| HOGENOM | HBG413852. |
| OMA | RRMERKN. |
| PhylomeDB | Q821S4. |
Enzyme and pathway databases | |
| BioCyc | CCAV227941:CCA_00863-MONOMER. |
| BRENDA | 6.3.2.4. 304519. 6.3.2.8. 304519. |
Family and domain databases | |
| HAMAP | MF_00046. MurC. Fused. [Tree] MF_00047. Dala_Dala_lig. Fused. [Tree] |
| InterPro | IPR011761. ATP-grasp. IPR013816. ATP_grasp_subdomain_2. IPR000291. D-Ala_lig_Van_CS. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR011127. Dala_Dala_lig_N. IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR016185. PreATP-grasp-like. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view] |
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF07478. Dala_Dala_lig_C. 1 hit. PF01820. Dala_Dala_lig_N. 1 hit. PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01205. D_ala_D_alaTIGR. 1 hit. TIGR01082. murC. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS00843. DALA_DALA_LIGASE_1. 1 hit. PS00844. DALA_DALA_LIGASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MUDD_CHLCV | ||||||||
| Accession | Primary (citable) accession number: Q821S4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


