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Q821S4

- MUDD_CHLCV

UniProt

Q821S4 - MUDD_CHLCV

Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddlA

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.
    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi739 – 7391Magnesium or manganese 1By similarity
    Metal bindingi752 – 7521Magnesium or manganese 1By similarity
    Metal bindingi752 – 7521Magnesium or manganese 2By similarity
    Metal bindingi754 – 7541Magnesium or manganese 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi111 – 1177ATPSequence Analysis
    Nucleotide bindingi607 – 66256ATPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCAV227941:GH8L-896-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional enzyme MurC/Ddl
    Including the following 2 domains:
    UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase
    D-alanine--D-alanine ligase (EC:6.3.2.4)
    Alternative name(s):
    D-Ala-D-Ala ligase
    D-alanylalanine synthetase
    Gene namesi
    Name:murC/ddlA
    Ordered Locus Names:CCA_00863
    OrganismiChlamydophila caviae (strain GPIC)
    Taxonomic identifieri227941 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000002193: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 811811Bifunctional enzyme MurC/DdlPRO_0000177913Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227941.CCA00863.

    Structurei

    3D structure databases

    ProteinModelPortaliQ821S4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini574 – 785212ATP-graspAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 450450UDP-N-acetylmuramate--alanine ligaseAdd
    BLAST
    Regioni451 – 811361D-alanine--D-alanine ligaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the MurCDEF family.Curated
    In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated
    Contains 1 ATP-grasp domain.Curated

    Phylogenomic databases

    eggNOGiCOG1181.
    KOiK01921.
    K01924.
    OMAiRIDFFLD.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.1190.10. 1 hit.
    3.40.50.20. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00046. MurC.
    MF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view]
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    TIGR01082. murC. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q821S4-1 [UniParc]FASTAAdd to Basket

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    MNRKNHYHFI GIGGIGMSAL AHILLDRGYS VSGSDLNQGI TIDKLIAKGA    50
    AYLPGHKESY VPEEGTIIYG SGIAKDNVEY KEALRKQLPL VHRAELLALL 100
    MQEQTSILVS GSHGKTTVSS LITAIFQTAK KDPSYAIGGL NSQYLNGYSG 150
    SSEYFIAEAD ESDGSLKHYF PKVAVVTNLD NEHLSNFEGS KEKLAQTIEE 200
    FTRKVDDPNL CFYNGDCQEL KGRISGISYG FSQECALYIY SHRQEGWRSV 250
    FSLSFLGKDY LDIDLNLIGK HNVANAAAAI GVALTFGIDE ESIREALKSF 300
    SGVQRRMERK NTSEKFLFLE DYAHHPSEIS CTLRALRDAV GLRRIIAICQ 350
    PHRFSRLLYC LEEFFNAFQD ADEVILTDVY SAGEMPLDLP SPEKLAETIS 400
    LSSHVCCTYV PYDNVIEHLK QNIRVHDVCI SLGAGNIHTV GNALKDFEPK 450
    KLSVGVVCGG QSCEHDVSLL SARNVVQYLS PQHYDVQYFV INRQGLWSQV 500
    ANLDAGSDYN SKNYHVLSSK IAEALANLDF VLPILHGPFG EDGTLQGFLE 550
    IANKPYGGPS LLFSAISMDK IMTKRLAASV GVPVVPYQPL TLPTWKRTPE 600
    LCMRRILETF TFPMFVKTAH LGSSIGVFEV HNETELKAKI SEAFLYDTDV 650
    FIEESRLGSR EIEVSCLGDA CSCYYISEPH ERRGSKGFIG YEEKYGFNGK 700
    SSATIQYDLN LSEESKTRVK ELTERVYRVI QGKGSCRIDF FLDREGNFWL 750
    SEMNPIPGMT KSSPFLHDFA RLGWTFEQIV HQLIIAGLHK FDQKKKVSST 800
    FNKQCLLTAK S 811
    Length:811
    Mass (Da):90,491
    Last modified:June 1, 2003 - v1
    Checksum:i096AC84D620947F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05604.1.
    RefSeqiNP_829726.1. NC_003361.3.
    WP_011006818.1. NC_003361.3.

    Genome annotation databases

    EnsemblBacteriaiAAP05604; AAP05604; CCA_00863.
    GeneIDi1218548.
    KEGGicca:CCA00863.
    PATRICi20270857. VBIChlCav107360_0908.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05604.1 .
    RefSeqi NP_829726.1. NC_003361.3.
    WP_011006818.1. NC_003361.3.

    3D structure databases

    ProteinModelPortali Q821S4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227941.CCA00863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP05604 ; AAP05604 ; CCA_00863 .
    GeneIDi 1218548.
    KEGGi cca:CCA00863.
    PATRICi 20270857. VBIChlCav107360_0908.

    Phylogenomic databases

    eggNOGi COG1181.
    KOi K01921.
    K01924.
    OMAi RIDFFLD.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci CCAV227941:GH8L-896-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.1190.10. 1 hit.
    3.40.50.20. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00046. MurC.
    MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view ]
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    TIGR01082. murC. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
      Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
      , Rank R.G., Bavoil P.M., Fraser C.M.
      Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GPIC.

    Entry informationi

    Entry nameiMUDD_CHLCV
    AccessioniPrimary (citable) accession number: Q821S4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3