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Q821M4

- PCKG_CHLCV

UniProt

Q821M4 - PCKG_CHLCV

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene
pckG, pckA, CCA_00916
Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761Substrate By similarity
Binding sitei218 – 2181Substrate; via amide nitrogen By similarity
Metal bindingi225 – 2251Manganese By similarity
Binding sitei225 – 2251Substrate By similarity
Metal bindingi245 – 2451Manganese; via tele nitrogen By similarity
Binding sitei267 – 2671Substrate By similarity
Active sitei269 – 2691 By similarity
Metal bindingi292 – 2921Manganese By similarity
Binding sitei383 – 3831GTP By similarity
Binding sitei414 – 4141GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi268 – 2736GTP By similarity
Nucleotide bindingi508 – 5114GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCAV227941:GH8L-954-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Synonyms:pckA
Ordered Locus Names:CCA_00916
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000002193: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Phosphoenolpyruvate carboxykinase [GTP]UniRule annotationPRO_0000103596Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227941.CCA00916.

Structurei

3D structure databases

ProteinModelPortaliQ821M4.
SMRiQ821M4. Positions 11-600.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni381 – 3833Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
KOiK01596.
OMAiIDWHGND.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q821M4-1 [UniParc]FASTAAdd to Basket

« Hide

MTSAWSSEIQ HEGLKQWIQE VAELVTPDDI RICNGSDSEY AEVYGIMEKS    50
GVAIPLNPDV HPNCFLVRSS PEDVARVEQF TFICTTKKED AGPTNNWRDP 100
QEMRQELQGL FRGCMRGRTL YVIPFCMGPL NSPFSLIGVE LTDSPYVVCS 150
MKIMTRMGAE VLKSLGTTGS FHKCLHSVGA PLSPGEKDVA WPCNPKNMRI 200
VHFQDDSSVM SFGSGYGGNA LLGKKSVALR LASYIARSQG WLAEHMLIIG 250
VTNPEGQKKY FAASFPSACG KTNLAMLMPK IPGWEVECIG DDIAWIRPGP 300
DGRLYAVNPE FGFFGVAPGT SETTNPNALA TCKTNSVFTN VALTPDGNVW 350
WEGLTSQPPE GLIDWRGNPW QPGGAPAAHP NSRFTAPVKQ CPVLDPQWNS 400
PEGVPIEAII FGGRRSETIP LVYEALSWQH GVTIGASMSS ATTAAIVGEQ 450
GKLRHDPFAM LPFCGYNMAH YFDHWLSFAS NTSLKLPKIY GVNWFRKDKD 500
GNFIWPGFSD NLRVIEWIFR RTNGEESIAK KTPIGYLPEE SSLNLEGLNL 550
SSQALQDLLS VDVSGWLKEV ANVREYCKIF GSDLPQTITD ELFRIERELK 600
Length:600
Mass (Da):66,286
Last modified:June 1, 2003 - v1
Checksum:i5094CFC0E9691932
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015925 Genomic DNA. Translation: AAP05655.1.
RefSeqiNP_829777.1. NC_003361.3.

Genome annotation databases

EnsemblBacteriaiAAP05655; AAP05655; CCA_00916.
GeneIDi1218604.
KEGGicca:CCA00916.
PATRICi20270975. VBIChlCav107360_0961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015925 Genomic DNA. Translation: AAP05655.1 .
RefSeqi NP_829777.1. NC_003361.3.

3D structure databases

ProteinModelPortali Q821M4.
SMRi Q821M4. Positions 11-600.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227941.CCA00916.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP05655 ; AAP05655 ; CCA_00916 .
GeneIDi 1218604.
KEGGi cca:CCA00916.
PATRICi 20270975. VBIChlCav107360_0961.

Phylogenomic databases

eggNOGi COG1274.
KOi K01596.
OMAi IDWHGND.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci CCAV227941:GH8L-954-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
    Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
    , Rank R.G., Bavoil P.M., Fraser C.M.
    Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GPIC.

Entry informationi

Entry nameiPCKG_CHLCV
AccessioniPrimary (citable) accession number: Q821M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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