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Q821M4

- PCKG_CHLCV

UniProt

Q821M4 - PCKG_CHLCV

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761SubstrateUniRule annotation
    Binding sitei218 – 2181Substrate; via amide nitrogenUniRule annotation
    Metal bindingi225 – 2251ManganeseUniRule annotation
    Binding sitei225 – 2251SubstrateUniRule annotation
    Metal bindingi245 – 2451Manganese; via tele nitrogenUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Active sitei269 – 2691UniRule annotation
    Metal bindingi292 – 2921ManganeseUniRule annotation
    Binding sitei383 – 3831GTPUniRule annotation
    Binding sitei414 – 4141GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi268 – 2736GTPUniRule annotation
    Nucleotide bindingi508 – 5114GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCAV227941:GH8L-954-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Synonyms:pckA
    Ordered Locus Names:CCA_00916
    OrganismiChlamydophila caviae (strain GPIC)
    Taxonomic identifieri227941 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000002193: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103596Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227941.CCA00916.

    Structurei

    3D structure databases

    ProteinModelPortaliQ821M4.
    SMRiQ821M4. Positions 11-600.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni381 – 3833Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    KOiK01596.
    OMAiIDWHGND.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q821M4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSAWSSEIQ HEGLKQWIQE VAELVTPDDI RICNGSDSEY AEVYGIMEKS    50
    GVAIPLNPDV HPNCFLVRSS PEDVARVEQF TFICTTKKED AGPTNNWRDP 100
    QEMRQELQGL FRGCMRGRTL YVIPFCMGPL NSPFSLIGVE LTDSPYVVCS 150
    MKIMTRMGAE VLKSLGTTGS FHKCLHSVGA PLSPGEKDVA WPCNPKNMRI 200
    VHFQDDSSVM SFGSGYGGNA LLGKKSVALR LASYIARSQG WLAEHMLIIG 250
    VTNPEGQKKY FAASFPSACG KTNLAMLMPK IPGWEVECIG DDIAWIRPGP 300
    DGRLYAVNPE FGFFGVAPGT SETTNPNALA TCKTNSVFTN VALTPDGNVW 350
    WEGLTSQPPE GLIDWRGNPW QPGGAPAAHP NSRFTAPVKQ CPVLDPQWNS 400
    PEGVPIEAII FGGRRSETIP LVYEALSWQH GVTIGASMSS ATTAAIVGEQ 450
    GKLRHDPFAM LPFCGYNMAH YFDHWLSFAS NTSLKLPKIY GVNWFRKDKD 500
    GNFIWPGFSD NLRVIEWIFR RTNGEESIAK KTPIGYLPEE SSLNLEGLNL 550
    SSQALQDLLS VDVSGWLKEV ANVREYCKIF GSDLPQTITD ELFRIERELK 600
    Length:600
    Mass (Da):66,286
    Last modified:June 1, 2003 - v1
    Checksum:i5094CFC0E9691932
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05655.1.
    RefSeqiNP_829777.1. NC_003361.3.

    Genome annotation databases

    EnsemblBacteriaiAAP05655; AAP05655; CCA_00916.
    GeneIDi1218604.
    KEGGicca:CCA00916.
    PATRICi20270975. VBIChlCav107360_0961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05655.1 .
    RefSeqi NP_829777.1. NC_003361.3.

    3D structure databases

    ProteinModelPortali Q821M4.
    SMRi Q821M4. Positions 11-600.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227941.CCA00916.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP05655 ; AAP05655 ; CCA_00916 .
    GeneIDi 1218604.
    KEGGi cca:CCA00916.
    PATRICi 20270975. VBIChlCav107360_0961.

    Phylogenomic databases

    eggNOGi COG1274.
    KOi K01596.
    OMAi IDWHGND.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci CCAV227941:GH8L-954-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
      Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
      , Rank R.G., Bavoil P.M., Fraser C.M.
      Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GPIC.

    Entry informationi

    Entry nameiPCKG_CHLCV
    AccessioniPrimary (citable) accession number: Q821M4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3