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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144L-tryptophanUniRule annotation1
Binding sitei194ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14ATPUniRule annotation3
Nucleotide bindingi20 – 21ATPUniRule annotation2
Nucleotide bindingi156 – 158ATPUniRule annotation3
Nucleotide bindingi202 – 206ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCAV227941:G1G03-977-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:CCA_00961
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000002193 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366171 – 345Tryptophan--tRNA ligaseAdd BLAST345

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227941.CCA00961

Structurei

3D structure databases

ProteinModelPortaliQ821H9
SMRiQ821H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 21"HIGH" regionUniRule annotation9
Motifi202 – 206"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q821H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKKRVLTG DRPTGKLHLG HWVGSIKNRL DLQNNPAYDC FFIIADLHTL
60 70 80 90 100
TTRVRKEQVV DVDNHIYEVL ADWLSVGIDP NKSSIYLQSA IPEIYELHLL
110 120 130 140 150
FSMLISVNRI MGIPSLKEMA KNASIEEGGL SLGLMGYPVL QSADILLAKA
160 170 180 190 200
QLVPVGKDNE AHIELTRDIA RNFNRLYGEI FPEPETLQGE LTSLVGIDGQ
210 220 230 240 250
GKMSKSANNA IYLSDDDATI EDKVRRMYTD PNRIHASTPG RVEGNPLFIY
260 270 280 290 300
HDIFNPNKEE VEEFKTRYRQ GCIKDVEIKT RLAEELIRFL QPFREKRAEL
310 320 330 340
LAHPKILQEA LQKGTENMCA LAKETMEEVH NTLELSRKWR SRLSL
Length:345
Mass (Da):39,292
Last modified:June 1, 2003 - v1
Checksum:i98BCEBE7A04A4A86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015925 Genomic DNA Translation: AAP05700.1
RefSeqiWP_011006913.1, NC_003361.3

Genome annotation databases

EnsemblBacteriaiAAP05700; AAP05700; CCA_00961
KEGGicca:CCA_00961

Similar proteinsi

Entry informationi

Entry nameiSYW_CHLCV
AccessioniPrimary (citable) accession number: Q821H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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