Reviewed, UniProtKB/Swiss-Prot Q821F9 (NTPA_CHLCV)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CCA_00982

Organism

Chlamydophila caviae [Complete proteome] [HAMAP]

Taxonomic identifier

83557 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Nucleoside-triphosphatase		PRO_0000178148

Sequences

	Sequence		Length	Mass (Da)
	Q821F9-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0842DD2DF79E8ECA	FASTA	206	23,018
	10 20 30 40 50 60 MKIVIASCHG YKIRETKTFL KQLGSFDIFS LTDFPNYSAP KEIGCLPEEN ALAKGLHAAK 70 80 90 100 110 120 ELNSWVIADD TMLMVPALNG LPGKLSATFA GEDACDKDHR KKLLQEMQSL ESIVDRSAYF 130 140 150 160 170 180 ECCIVLASPE GKFFKARGIC EGYISNQEKG SSGFGYDSLF LKYDYKQTFA ELSEDVKNQV 190 200 SHRAKALQKL APYLQNLLEK QLVSRN

References

[1]

"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. , Rank R.G., Bavoil P.M., Fraser C.M. Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015925 Genomic DNA. Translation: AAP05721.1.
RefSeq	NP_829843.1.
3D structure databases
HSSP	HSSP built from PDB template 2MJP based on UniProtKB Q57679.
ModBase	Search...
Genome annotation databases
GeneID	1218670.
GenomeReviews	Gene locus CCA_00982 in contig AE015925_GR.
KEGG	cca:CCA00982.
TIGR	CCA_00982.
Phylogenomic databases
HOGENOM	Q821F9.
Enzyme and pathway databases
BioCyc	CCAV227941:CCA_00982-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_CHLCV

Accession

Primary (citable) accession number: Q821F9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	June 1, 2003
Last modified:	July 22, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)