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Q821E2 (FOLKP_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Folate synthesis bifunctional protein

Including the following 2 domains:

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
    EC=2.7.6.3
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name=PPPK
    7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name=HPPK
  2. Dihydropteroate synthase
    Short name=DHPS
    EC=2.5.1.15
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
Gene names
Name:folKP
Ordered Locus Names:CCA_00999
OrganismChlamydophila caviae (strain GPIC) [Complete proteome] [HAMAP]
Taxonomic identifier227941 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactor

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Sequence similarities

In the N-terminal section; belongs to the HPPK family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Folate synthesis bifunctional protein
PRO_0000168238

Regions

Domain179 – 438260Pterin-binding
Region1 – 165165HPPK
Region226 – 2272Substrate binding By similarity

Sites

Metal binding1861Magnesium By similarity
Binding site1941Substrate By similarity
Binding site2661Substrate By similarity
Binding site2861Substrate By similarity
Binding site3561Substrate By similarity
Binding site3921Substrate By similarity
Binding site4261Substrate By similarity
Binding site4281Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q821E2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: DA22B1F8B954599D

FASTA44750,077
        10         20         30         40         50         60 
MTTAQFICLS LGSNLGNRFE IFRKAFALLK ELEIEDLQSS IILETKALLL PGSPKEWDLP 

        70         80         90        100        110        120 
FFNSVLIGKT TLSPKQLLSG VKQIERRLGR DVNALPWSPR VLDIDILLYG DENHQQEDVK 

       130        140        150        160        170        180 
IPHERITERP FLLSLIASLC PTRIFHKPGS EYHLKSFGEI AHLLPCPQEM ILNSFSPNTL 

       190        200        210        220        230        240 
LMGVVNVTDN SISDEGLYLE ASKAVAHAEK LFAQGASVID FGGQATNPKV QQLLNVEQEW 

       250        260        270        280        290        300 
SRLEPVLKLL AEKWAGRRQY PDISLDTFYP EIIKRALEIY PIRWINDVSG GSKEMAEIAR 

       310        320        330        340        350        360 
DANLLLVINH SCSLPPRPDK TLAFTTCASD QLLSWGEKQI EAFVALGLRQ DQIIFDPGIG 

       370        380        390        400        410        420 
FGTTQIQALN VLHKMKKFRK LGCATLVGHS RKSCFSLLGK YDAKDRDWET VSLSVLLQQQ 

       430        440 
GVNYLRVHDV EANQRVLSAA AWSGVHV 

« Hide

References

[1]"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. expand/collapse author list , Rank R.G., Bavoil P.M., Fraser C.M.
Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GPIC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015925 Genomic DNA. Translation: AAP05738.1.
RefSeqNP_829860.1. NC_003361.3.

3D structure databases

ProteinModelPortalQ821E2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227941.CCA00999.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP05738; AAP05738; CCA_00999.
GeneID1218687.
KEGGcca:CCA00999.
PATRIC20271153. VBIChlCav107360_1048.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0294.
KOK13941.
OMAKYVITHN.
OrthoDBEOG67T5P5.

Enzyme and pathway databases

BioCycCCAV227941:GH8L-1039-MONOMER.
UniPathwayUPA00077; UER00155.
UPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLKP_CHLCV
AccessionPrimary (citable) accession number: Q821E2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways