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Q821E2

- FOLKP_CHLCV

UniProt

Q821E2 - FOLKP_CHLCV

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Protein

Folate synthesis bifunctional protein

Gene
folKP, CCA_00999
Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi186 – 1861Magnesium By similarity
Binding sitei194 – 1941Substrate By similarity
Binding sitei266 – 2661Substrate By similarity
Binding sitei286 – 2861Substrate By similarity
Binding sitei356 – 3561Substrate By similarity
Binding sitei392 – 3921Substrate By similarity
Binding sitei426 – 4261Substrate By similarity
Binding sitei428 – 4281Substrate By similarity

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. dihydropteroate synthase activity Source: UniProtKB-EC
  4. kinase activity Source: UniProtKB-KW
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCAV227941:GH8L-1039-MONOMER.
UniPathwayiUPA00077; UER00155.
UPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Folate synthesis bifunctional protein
Including the following 2 domains:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folKP
Ordered Locus Names:CCA_00999
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000002193: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Folate synthesis bifunctional proteinPRO_0000168238Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227941.CCA00999.

Structurei

3D structure databases

ProteinModelPortaliQ821E2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 438260Pterin-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 165165HPPKAdd
BLAST
Regioni226 – 2272Substrate binding By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the HPPK family.

Phylogenomic databases

eggNOGiCOG0294.
KOiK13941.
OMAiKYVITHN.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q821E2-1 [UniParc]FASTAAdd to Basket

« Hide

MTTAQFICLS LGSNLGNRFE IFRKAFALLK ELEIEDLQSS IILETKALLL    50
PGSPKEWDLP FFNSVLIGKT TLSPKQLLSG VKQIERRLGR DVNALPWSPR 100
VLDIDILLYG DENHQQEDVK IPHERITERP FLLSLIASLC PTRIFHKPGS 150
EYHLKSFGEI AHLLPCPQEM ILNSFSPNTL LMGVVNVTDN SISDEGLYLE 200
ASKAVAHAEK LFAQGASVID FGGQATNPKV QQLLNVEQEW SRLEPVLKLL 250
AEKWAGRRQY PDISLDTFYP EIIKRALEIY PIRWINDVSG GSKEMAEIAR 300
DANLLLVINH SCSLPPRPDK TLAFTTCASD QLLSWGEKQI EAFVALGLRQ 350
DQIIFDPGIG FGTTQIQALN VLHKMKKFRK LGCATLVGHS RKSCFSLLGK 400
YDAKDRDWET VSLSVLLQQQ GVNYLRVHDV EANQRVLSAA AWSGVHV 447
Length:447
Mass (Da):50,077
Last modified:June 1, 2003 - v1
Checksum:iDA22B1F8B954599D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015925 Genomic DNA. Translation: AAP05738.1.
RefSeqiNP_829860.1. NC_003361.3.
WP_011006951.1. NC_003361.3.

Genome annotation databases

EnsemblBacteriaiAAP05738; AAP05738; CCA_00999.
GeneIDi1218687.
KEGGicca:CCA00999.
PATRICi20271153. VBIChlCav107360_1048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015925 Genomic DNA. Translation: AAP05738.1 .
RefSeqi NP_829860.1. NC_003361.3.
WP_011006951.1. NC_003361.3.

3D structure databases

ProteinModelPortali Q821E2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227941.CCA00999.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP05738 ; AAP05738 ; CCA_00999 .
GeneIDi 1218687.
KEGGi cca:CCA00999.
PATRICi 20271153. VBIChlCav107360_1048.

Phylogenomic databases

eggNOGi COG0294.
KOi K13941.
OMAi KYVITHN.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00155 .
UPA00077 ; UER00156 .
BioCyci CCAV227941:GH8L-1039-MONOMER.

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
    Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
    , Rank R.G., Bavoil P.M., Fraser C.M.
    Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GPIC.

Entry informationi

Entry nameiFOLKP_CHLCV
AccessioniPrimary (citable) accession number: Q821E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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