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Q821E2

- FOLKP_CHLCV

UniProt

Q821E2 - FOLKP_CHLCV

Protein

Folate synthesis bifunctional protein

Gene

folKP

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
    (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

    Cofactori

    Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi186 – 1861MagnesiumBy similarity
    Binding sitei194 – 1941SubstrateBy similarity
    Binding sitei266 – 2661SubstrateBy similarity
    Binding sitei286 – 2861SubstrateBy similarity
    Binding sitei356 – 3561SubstrateBy similarity
    Binding sitei392 – 3921SubstrateBy similarity
    Binding sitei426 – 4261SubstrateBy similarity
    Binding sitei428 – 4281SubstrateBy similarity

    GO - Molecular functioni

    1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. dihydropteroate synthase activity Source: UniProtKB-EC
    4. kinase activity Source: UniProtKB-KW
    5. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Folate biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCAV227941:GH8L-1039-MONOMER.
    UniPathwayiUPA00077; UER00155.
    UPA00077; UER00156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Folate synthesis bifunctional protein
    Including the following 2 domains:
    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name:
    PPPK
    7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name:
    HPPK
    Dihydropteroate synthase (EC:2.5.1.15)
    Short name:
    DHPS
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
    Gene namesi
    Name:folKP
    Ordered Locus Names:CCA_00999
    OrganismiChlamydophila caviae (strain GPIC)
    Taxonomic identifieri227941 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000002193: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Folate synthesis bifunctional proteinPRO_0000168238Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227941.CCA00999.

    Structurei

    3D structure databases

    ProteinModelPortaliQ821E2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini179 – 438260Pterin-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 165165HPPKAdd
    BLAST
    Regioni226 – 2272Substrate bindingBy similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the HPPK family.Curated
    Contains 1 pterin-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0294.
    KOiK13941.
    OMAiKYVITHN.
    OrthoDBiEOG67T5P5.

    Family and domain databases

    Gene3Di3.20.20.20. 1 hit.
    3.30.70.560. 1 hit.
    InterProiIPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000550. Hppk.
    IPR000489. Pterin-binding.
    [Graphical view]
    PfamiPF01288. HPPK. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF51717. SSF51717. 1 hit.
    SSF55083. SSF55083. 1 hit.
    TIGRFAMsiTIGR01496. DHPS. 1 hit.
    TIGR01498. folK. 1 hit.
    PROSITEiPS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q821E2-1 [UniParc]FASTAAdd to Basket

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    MTTAQFICLS LGSNLGNRFE IFRKAFALLK ELEIEDLQSS IILETKALLL    50
    PGSPKEWDLP FFNSVLIGKT TLSPKQLLSG VKQIERRLGR DVNALPWSPR 100
    VLDIDILLYG DENHQQEDVK IPHERITERP FLLSLIASLC PTRIFHKPGS 150
    EYHLKSFGEI AHLLPCPQEM ILNSFSPNTL LMGVVNVTDN SISDEGLYLE 200
    ASKAVAHAEK LFAQGASVID FGGQATNPKV QQLLNVEQEW SRLEPVLKLL 250
    AEKWAGRRQY PDISLDTFYP EIIKRALEIY PIRWINDVSG GSKEMAEIAR 300
    DANLLLVINH SCSLPPRPDK TLAFTTCASD QLLSWGEKQI EAFVALGLRQ 350
    DQIIFDPGIG FGTTQIQALN VLHKMKKFRK LGCATLVGHS RKSCFSLLGK 400
    YDAKDRDWET VSLSVLLQQQ GVNYLRVHDV EANQRVLSAA AWSGVHV 447
    Length:447
    Mass (Da):50,077
    Last modified:June 1, 2003 - v1
    Checksum:iDA22B1F8B954599D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05738.1.
    RefSeqiNP_829860.1. NC_003361.3.
    WP_011006951.1. NC_003361.3.

    Genome annotation databases

    EnsemblBacteriaiAAP05738; AAP05738; CCA_00999.
    GeneIDi1218687.
    KEGGicca:CCA00999.
    PATRICi20271153. VBIChlCav107360_1048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05738.1 .
    RefSeqi NP_829860.1. NC_003361.3.
    WP_011006951.1. NC_003361.3.

    3D structure databases

    ProteinModelPortali Q821E2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227941.CCA00999.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP05738 ; AAP05738 ; CCA_00999 .
    GeneIDi 1218687.
    KEGGi cca:CCA00999.
    PATRICi 20271153. VBIChlCav107360_1048.

    Phylogenomic databases

    eggNOGi COG0294.
    KOi K13941.
    OMAi KYVITHN.
    OrthoDBi EOG67T5P5.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00155 .
    UPA00077 ; UER00156 .
    BioCyci CCAV227941:GH8L-1039-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.20. 1 hit.
    3.30.70.560. 1 hit.
    InterProi IPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000550. Hppk.
    IPR000489. Pterin-binding.
    [Graphical view ]
    Pfami PF01288. HPPK. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51717. SSF51717. 1 hit.
    SSF55083. SSF55083. 1 hit.
    TIGRFAMsi TIGR01496. DHPS. 1 hit.
    TIGR01498. folK. 1 hit.
    PROSITEi PS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
      Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
      , Rank R.G., Bavoil P.M., Fraser C.M.
      Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GPIC.

    Entry informationi

    Entry nameiFOLKP_CHLCV
    AccessioniPrimary (citable) accession number: Q821E2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3