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Q820Y9

- PNP_TROW8

UniProt

Q820Y9 - PNP_TROW8

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, TW347
Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi525 – 5251Magnesium By similarity
Metal bindingi531 – 5311Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:TW347
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329923Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218496.TW347.

Structurei

3D structure databases

ProteinModelPortaliQ820Y9.
SMRiQ820Y9. Positions 2-627.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini591 – 65060KH
Add
BLAST
Domaini662 – 73473S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q820Y9-1 [UniParc]FASTAAdd to Basket

« Hide

MQFSEGVIDN GRFGTRTIRF ETGRLARQAQ GSVVAYLDGE TMLLSSTSVG    50
KQPKEDCDFF PLTVDVEERS YAAGKIPGSY FRREGRPSTE AILACRLIDR 100
PLRPSFNAGL RNEVQVIVTV LSIAPGEFYE ALAINAASAS TLVSGLPFSG 150
PIGGVRLALI DGQWVAFPRY EDLSGAVFDL TVAGRVFVNE SGKEDIAIMM 200
VEAEATEPAW DLIHSHGAKK PNEEVIEEGI ESAKVFIRTL CDIQRDLASK 250
LSLSHTEPDL YPDYSDSVHS FVEGLVKSDL EKVYRGNHDS GYAPNALSAS 300
DEIKQKAYDA FHDAVLSGRF DQDSLSQFPH AYKAVLKDVV RTCVLEGFAR 350
MDGRGLSDIR PLDAEVQVVP RVHGSAVFQR GETQVLGVTT LNMLKMEQQI 400
DSLAPIVSKR YIHHYNFPPY STGEVGRVGS PKRREIGHGF LAERALVPVL 450
PSREDFPYAI RQVSEALGSN GSTSMGSVCA STLSLLNAGV PLRAPVAGIA 500
MGLISGRVDG EMRYVTLTDI SGSEDALGDM DFKVAGTSDF ITALQLDTKL 550
DGIPAHVLSE ALAHARSARL AILDVLTRVI DSPDQMSEYA PRVVRVKIPV 600
QKIGELIGPK GKVINSIQDE TGAEISIEDD GTVYIGSSQA DSSEKAVAMV 650
NSIVNPVEPC VGSQFLGTVV KNMPFGSFIS LVPGKDGLLH ISEIRKMVDG 700
RHLESVDEVL SVGQKVLVEV SKIDDRGKLC LVAVK 735
Length:735
Mass (Da):79,495
Last modified:June 1, 2003 - v1
Checksum:i7351C9C9781A3CE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251411 Genomic DNA. Translation: CAD67019.1.
RefSeqiNP_789281.1. NC_004551.1.

Genome annotation databases

EnsemblBacteriaiCAD67019; CAD67019; TW347.
GeneIDi1064634.
KEGGitws:TW347.
PATRICi23999153. VBITroWhi42739_0412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251411 Genomic DNA. Translation: CAD67019.1 .
RefSeqi NP_789281.1. NC_004551.1.

3D structure databases

ProteinModelPortali Q820Y9.
SMRi Q820Y9. Positions 2-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218496.TW347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD67019 ; CAD67019 ; TW347 .
GeneIDi 1064634.
KEGGi tws:TW347.
PATRICi 23999153. VBITroWhi42739_0412.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiPNP_TROW8
AccessioniPrimary (citable) accession number: Q820Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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