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Q820Y9

- PNP_TROW8

UniProt

Q820Y9 - PNP_TROW8

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi525 – 5251MagnesiumUniRule annotation
Metal bindingi531 – 5311MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:TW347
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Polyribonucleotide nucleotidyltransferasePRO_0000329923Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218496.TW347.

Structurei

3D structure databases

ProteinModelPortaliQ820Y9.
SMRiQ820Y9. Positions 2-627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini591 – 65060KHUniRule annotationAdd
BLAST
Domaini662 – 73473S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q820Y9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFSEGVIDN GRFGTRTIRF ETGRLARQAQ GSVVAYLDGE TMLLSSTSVG
60 70 80 90 100
KQPKEDCDFF PLTVDVEERS YAAGKIPGSY FRREGRPSTE AILACRLIDR
110 120 130 140 150
PLRPSFNAGL RNEVQVIVTV LSIAPGEFYE ALAINAASAS TLVSGLPFSG
160 170 180 190 200
PIGGVRLALI DGQWVAFPRY EDLSGAVFDL TVAGRVFVNE SGKEDIAIMM
210 220 230 240 250
VEAEATEPAW DLIHSHGAKK PNEEVIEEGI ESAKVFIRTL CDIQRDLASK
260 270 280 290 300
LSLSHTEPDL YPDYSDSVHS FVEGLVKSDL EKVYRGNHDS GYAPNALSAS
310 320 330 340 350
DEIKQKAYDA FHDAVLSGRF DQDSLSQFPH AYKAVLKDVV RTCVLEGFAR
360 370 380 390 400
MDGRGLSDIR PLDAEVQVVP RVHGSAVFQR GETQVLGVTT LNMLKMEQQI
410 420 430 440 450
DSLAPIVSKR YIHHYNFPPY STGEVGRVGS PKRREIGHGF LAERALVPVL
460 470 480 490 500
PSREDFPYAI RQVSEALGSN GSTSMGSVCA STLSLLNAGV PLRAPVAGIA
510 520 530 540 550
MGLISGRVDG EMRYVTLTDI SGSEDALGDM DFKVAGTSDF ITALQLDTKL
560 570 580 590 600
DGIPAHVLSE ALAHARSARL AILDVLTRVI DSPDQMSEYA PRVVRVKIPV
610 620 630 640 650
QKIGELIGPK GKVINSIQDE TGAEISIEDD GTVYIGSSQA DSSEKAVAMV
660 670 680 690 700
NSIVNPVEPC VGSQFLGTVV KNMPFGSFIS LVPGKDGLLH ISEIRKMVDG
710 720 730
RHLESVDEVL SVGQKVLVEV SKIDDRGKLC LVAVK
Length:735
Mass (Da):79,495
Last modified:June 1, 2003 - v1
Checksum:i7351C9C9781A3CE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX251411 Genomic DNA. Translation: CAD67019.1.
RefSeqiNP_789281.1. NC_004551.1.

Genome annotation databases

EnsemblBacteriaiCAD67019; CAD67019; TW347.
GeneIDi1064634.
KEGGitws:TW347.
PATRICi23999153. VBITroWhi42739_0412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX251411 Genomic DNA. Translation: CAD67019.1 .
RefSeqi NP_789281.1. NC_004551.1.

3D structure databases

ProteinModelPortali Q820Y9.
SMRi Q820Y9. Positions 2-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218496.TW347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD67019 ; CAD67019 ; TW347 .
GeneIDi 1064634.
KEGGi tws:TW347.
PATRICi 23999153. VBITroWhi42739_0412.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiPNP_TROW8
AccessioniPrimary (citable) accession number: Q820Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3