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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC:2.4.1.227)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene namesi
Name:murG
Ordered Locus Names:CBU_0135
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane ; Peripheral membrane protein

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001091691 – 358UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST358

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0135.

Structurei

3D structure databases

ProteinModelPortaliQ820X3.
SMRiQ820X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218321.
KOiK02563.
OMAiHQTKNAM.

Family and domain databases

CDDicd03785. GT1_MurG. 1 hit.
HAMAPiMF_00033. MurG. 1 hit.
InterProiView protein in InterPro
IPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
PfamiView protein in Pfam
PF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q820X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRILIIAGG TGGHIFPALA VARELREQEV DVQWLGVKGG LEEKLVPDSF
60 70 80 90 100
PLHLIQIKAF RGKRGLQQLL MPLRLVRAVF QAYRIIRQFK PDVILGMGGY
110 120 130 140 150
VAGPGGLAAW ITRTPLIIHE QNSIPGLTNR VLAKMAKFIL QGFPDTFPQN
160 170 180 190 200
RKVITTGNPV RTELVKMPLP QVRLAARRGP LRILVLGGSQ GARSINQKML
210 220 230 240 250
AALSSYPRSE EIAVWHQTGQ RDFEFIQKEY EKIKIEAKVD NFISDMAGAY
260 270 280 290 300
GWADLVVCRA GALTVCEIAS VGVASIFIPY PHAVDNHQFH NARFLEQAGA
310 320 330 340 350
AIIISEESLT ETDLMRWFEQ FAQDRDRLLT MAENARKLAK PEAVQRVIAQ

CKKFYAAR
Length:358
Mass (Da):39,974
Last modified:June 1, 2003 - v1
Checksum:i5BF7E97212E90AB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89699.1.
RefSeqiNP_819185.1. NC_002971.3.
WP_005769484.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaiAAO89699; AAO89699; CBU_0135.
GeneIDi1208006.
KEGGicbu:CBU_0135.
PATRICifig|227377.7.peg.137.

Similar proteinsi

Entry informationi

Entry nameiMURG_COXBU
AccessioniPrimary (citable) accession number: Q820X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families