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Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs.

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine(37) in tRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114S-adenosyl-L-methionine; via amide nitrogen1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferase (EC:2.1.1.228)
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene namesi
Name:trmD
Ordered Locus Names:CBU_0443
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000603671 – 246tRNA (guanine-N(1)-)-methyltransferaseAdd BLAST246

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi227377.CBU_0443.

Structurei

3D structure databases

ProteinModelPortaliQ820X1.
SMRiQ820X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 139S-adenosyl-L-methionine binding6

Sequence similaritiesi

Belongs to the RNA methyltransferase TrmD family.

Phylogenomic databases

eggNOGiENOG4105D6X. Bacteria.
COG0336. LUCA.
HOGENOMiHOG000016242.
KOiK00554.
OMAiILCGHYK.

Family and domain databases

Gene3Di3.40.1280.10. 1 hit.
HAMAPiMF_00605. TrmD. 1 hit.
InterProiView protein in InterPro
IPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
PANTHERiPTHR32125:SF1. PTHR32125:SF1. 1 hit.
PfamiView protein in Pfam
PF01746. tRNA_m1G_MT. 1 hit.
PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00088. trmD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q820X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLIIGVITL FPQMFDALKS GVIGRALKQD RLTLSCWNPR DYATDPHRTV
60 70 80 90 100
DDRPYGGGPG MVMKFEPLAL ALKAAKAQLG ENTKVIHLTP QGKLLTQAIV
110 120 130 140 150
REKIHASPLI LLAGRYEGID ERLIEAEVDE EWSIGDYILS GGELPAMVLI
160 170 180 190 200
DAMTRLLPGV LGHKDSASQD SFTAGLLDYP HYTRPEKIAD RPVPSVLLSG
210 220 230 240
DHEAISRWRL KQSLGRTWQR RQDLIKRRSL SENEQRLLDE FFEESS
Length:246
Mass (Da):27,611
Last modified:June 1, 2003 - v1
Checksum:i6F82538240A955B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89994.1.
RefSeqiNP_819480.1. NC_002971.3.
WP_010957578.1. NC_002971.4.

Genome annotation databases

EnsemblBacteriaiAAO89994; AAO89994; CBU_0443.
GeneIDi1208327.
KEGGicbu:CBU_0443.
PATRICifig|227377.7.peg.434.

Similar proteinsi

Entry informationi

Entry nameiTRMD_COXBU
AccessioniPrimary (citable) accession number: Q820X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families