Q820W7 (FABZ_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
EC=4.2.1.59

Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name=(3R)-hydroxymyristoyl-ACP dehydrase
Beta-hydroxyacyl-ACP dehydratase

Gene names

Name:	fabZ
Ordered Locus Names:	CBU_0614

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs By similarity. HAMAP-Rule MF_00406
Catalytic activity	A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O. HAMAP-Rule MF_00406
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00406.
Sequence similarities	Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ HAMAP-Rule MF_00406		PRO_0000091669
Sites
	Active site	50	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q820W7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7C56A267EBE1F9FE	FASTA	145	16,369
	10 20 30 40 50 60 MNVMNITDIK KYIPHRYPFL LIDRVIKIEK DKSLVAIKNV TVNEPFFTGH FPVRPVMPGV 70 80 90 100 110 120 LIIESLAQAA GILIVKSLNL PEGHKDIYFF AGVDNARFKR VVEPGDQLTL EVKVLKVHRG 130 140 LWKFEGKATV DDQLACKAEL MTIKG

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO90158.1.
RefSeq	NP_819644.1. NC_002971.3.
3D structure databases
ProteinModelPortal	Q820W7.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_0614.
Proteomic databases
PRIDE	Q820W7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO90158; AAO90158; CBU_0614.
GeneID	1208499.
KEGG	cbu:CBU_0614.
PATRIC	17929915. VBICoxBur82552_0602.
Phylogenomic databases
eggNOG	COG0764.
HOGENOM	HOG000277829.
KO	K02372.
OMA	KERRGVA.
ProtClustDB	PRK00006.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-612-MONOMER.
Family and domain databases
HAMAP	MF_00406. FabZ.
InterPro	IPR013114. FabA_FabZ. IPR010084. FabZ. [Graphical view]
Pfam	PF07977. FabA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01750. fabZ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABZ_COXBU

Accession

Primary (citable) accession number: Q820W7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program