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Q820S1 (PTA_NITEU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphate acetyltransferase

EC=2.3.1.8
Alternative name(s):
Phosphotransacetylase
Gene names
Name:pta
Ordered Locus Names:NE0298
OrganismNitrosomonas europaea (strain ATCC 19718 / NBRC 14298) [Complete proteome] [HAMAP]
Taxonomic identifier228410 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in acetate metabolism By similarity.

Catalytic activity

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm Potential.

Domain

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.

Sequence similarities

In the N-terminal section; belongs to the CobB/CobQ family.

In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processacetyl-CoA biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphate acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695Phosphate acetyltransferase
PRO_0000405548

Regions

Region372 – 695324Phosphate acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
Q820S1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 711FE70A7908EC5D

FASTA69574,998
        10         20         30         40         50         60 
MHTFFVTSTG FGVGLTSTSL GLVRALEYGG LKAGFYKPVA QQHPGNSKLE YSTELISRTL 

        70         80         90        100        110        120 
GLAPPAPLPL ATVEHLLGEG QIDDLMEDIV RRFKQASEGY DVMVVEGMVP TRHVSYASRV 

       130        140        150        160        170        180 
NTRLASSLDA DIILVSSAED DALQAITDRI EIQAQFFGGA QNPRLLGVIL NKIRTDHSDD 

       190        200        210        220        230        240 
LFEQLKNHST LFHQSSFQIL GCIPWEDSLN APRMADVVTQ LQAQIVNAGD SEKRRVQDIV 

       250        260        270        280        290        300 
LFASAAPNSV TLLRPGVLVV TPGDRDDIVM AASLAVLNGV PLAGLLLCSD FPPDPRVLEL 

       310        320        330        340        350        360 
CKGALTKGLP VCTVTTNSYD TAANLHRMNR EIPLDDHERA ERITNFVANH IRQELLVKRC 

       370        380        390        400        410        420 
GEPQEQRLSP PAFRYRLVKR AQEADCRIVL PEGYEPRTIQ AATICQERGI ARCVLLAKPD 

       430        440        450        460        470        480 
AVKAVASARG ITLPEGLEMI DPEKVRRNYV AAMVELRKHK GLNEPMALAQ LEDNVVLGTM 

       490        500        510        520        530        540 
MLATGEVDGL VSGAINTTAN TIRPALQLIK TAPGFKLVSS VFFMLLPEQV VVYGDCAVNP 

       550        560        570        580        590        600 
NPTAEELADI ALQSAASAQA LGIEPRVAML SYSTGDSGSG QEVEKVREAT RLARLARPDL 

       610        620        630        640        650        660 
LIDGPLQYDA AAIASVGRQK APGSPVAGRA TVFIFPDLNT GNTTYKAVQR SANVVSVGPM 

       670        680        690 
LQGLRKPVND LSRGASVEDI VYTIALTAVQ AASQR 

« Hide

References

[1]"Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19718 / NBRC 14298.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL954747 Genomic DNA. Translation: CAD84209.1.
RefSeqNP_840385.1. NC_004757.1.

3D structure databases

ProteinModelPortalQ820S1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228410.NE0298.

Proteomic databases

PRIDEQ820S1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD84209; CAD84209; NE0298.
GeneID1081227.
KEGGneu:NE0298.
PATRIC22711429. VBINitEur56163_0329.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0280.
HOGENOMHOG000053797.
KOK13788.
OMAKPIAQPH.
OrthoDBEOG6BKJ5W.
ProtClustDBPRK05632.

Enzyme and pathway databases

BioCycNEUR228410:GJNO-308-MONOMER.
UniPathwayUPA00340; UER00459.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00651. pta. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTA_NITEU
AccessionPrimary (citable) accession number: Q820S1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways