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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphate acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-308-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:NE0298
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Phosphate acetyltransferasePRO_0000405548Add
BLAST

Proteomic databases

PRIDEiQ820S1.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi228410.NE0298.

Structurei

3D structure databases

ProteinModelPortaliQ820S1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni372 – 695324Phosphate acetyltransferaseAdd
BLAST

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.
PhylomeDBiQ820S1.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q820S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTFFVTSTG FGVGLTSTSL GLVRALEYGG LKAGFYKPVA QQHPGNSKLE
60 70 80 90 100
YSTELISRTL GLAPPAPLPL ATVEHLLGEG QIDDLMEDIV RRFKQASEGY
110 120 130 140 150
DVMVVEGMVP TRHVSYASRV NTRLASSLDA DIILVSSAED DALQAITDRI
160 170 180 190 200
EIQAQFFGGA QNPRLLGVIL NKIRTDHSDD LFEQLKNHST LFHQSSFQIL
210 220 230 240 250
GCIPWEDSLN APRMADVVTQ LQAQIVNAGD SEKRRVQDIV LFASAAPNSV
260 270 280 290 300
TLLRPGVLVV TPGDRDDIVM AASLAVLNGV PLAGLLLCSD FPPDPRVLEL
310 320 330 340 350
CKGALTKGLP VCTVTTNSYD TAANLHRMNR EIPLDDHERA ERITNFVANH
360 370 380 390 400
IRQELLVKRC GEPQEQRLSP PAFRYRLVKR AQEADCRIVL PEGYEPRTIQ
410 420 430 440 450
AATICQERGI ARCVLLAKPD AVKAVASARG ITLPEGLEMI DPEKVRRNYV
460 470 480 490 500
AAMVELRKHK GLNEPMALAQ LEDNVVLGTM MLATGEVDGL VSGAINTTAN
510 520 530 540 550
TIRPALQLIK TAPGFKLVSS VFFMLLPEQV VVYGDCAVNP NPTAEELADI
560 570 580 590 600
ALQSAASAQA LGIEPRVAML SYSTGDSGSG QEVEKVREAT RLARLARPDL
610 620 630 640 650
LIDGPLQYDA AAIASVGRQK APGSPVAGRA TVFIFPDLNT GNTTYKAVQR
660 670 680 690
SANVVSVGPM LQGLRKPVND LSRGASVEDI VYTIALTAVQ AASQR
Length:695
Mass (Da):74,998
Last modified:June 1, 2003 - v1
Checksum:i711FE70A7908EC5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84209.1.
RefSeqiNP_840385.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD84209; CAD84209; NE0298.
GeneIDi1081227.
KEGGineu:NE0298.
PATRICi22711429. VBINitEur56163_0329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84209.1.
RefSeqiNP_840385.1. NC_004757.1.

3D structure databases

ProteinModelPortaliQ820S1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228410.NE0298.

Proteomic databases

PRIDEiQ820S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD84209; CAD84209; NE0298.
GeneIDi1081227.
KEGGineu:NE0298.
PATRICi22711429. VBINitEur56163_0329.

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.
PhylomeDBiQ820S1.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciNEUR228410:GJNO-308-MONOMER.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiPTA_NITEU
AccessioniPrimary (citable) accession number: Q820S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: June 1, 2003
Last modified: March 4, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.