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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA2)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciNEUR228410:G1G1I-333-MONOMER
UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:NE0298
OrganismiNitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001416 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055481 – 695Phosphate acetyltransferaseAdd BLAST695

Proteomic databases

PRIDEiQ820S1

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi228410.NE0298

Structurei

3D structure databases

ProteinModelPortaliQ820S1
SMRiQ820S1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni372 – 695Phosphate acetyltransferaseAdd BLAST324

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280 LUCA
COG0857 LUCA
HOGENOMiHOG000053797
KOiK13788
OMAiTPLMFEY
OrthoDBiPOG091H01MW
PhylomeDBiQ820S1

Family and domain databases

Gene3Di3.40.1390.20, 1 hit
InterProiView protein in InterPro
IPR010766 DRTGG
IPR016475 P-Actrans_bac
IPR027417 P-loop_NTPase
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
IPR028979 Ser_kin/Pase_Hpr-like_N_sf
PfamiView protein in Pfam
PF07085 DRTGG, 1 hit
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF006107 PhpActrans_proteobac, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75138 SSF75138, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q820S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTFFVTSTG FGVGLTSTSL GLVRALEYGG LKAGFYKPVA QQHPGNSKLE
60 70 80 90 100
YSTELISRTL GLAPPAPLPL ATVEHLLGEG QIDDLMEDIV RRFKQASEGY
110 120 130 140 150
DVMVVEGMVP TRHVSYASRV NTRLASSLDA DIILVSSAED DALQAITDRI
160 170 180 190 200
EIQAQFFGGA QNPRLLGVIL NKIRTDHSDD LFEQLKNHST LFHQSSFQIL
210 220 230 240 250
GCIPWEDSLN APRMADVVTQ LQAQIVNAGD SEKRRVQDIV LFASAAPNSV
260 270 280 290 300
TLLRPGVLVV TPGDRDDIVM AASLAVLNGV PLAGLLLCSD FPPDPRVLEL
310 320 330 340 350
CKGALTKGLP VCTVTTNSYD TAANLHRMNR EIPLDDHERA ERITNFVANH
360 370 380 390 400
IRQELLVKRC GEPQEQRLSP PAFRYRLVKR AQEADCRIVL PEGYEPRTIQ
410 420 430 440 450
AATICQERGI ARCVLLAKPD AVKAVASARG ITLPEGLEMI DPEKVRRNYV
460 470 480 490 500
AAMVELRKHK GLNEPMALAQ LEDNVVLGTM MLATGEVDGL VSGAINTTAN
510 520 530 540 550
TIRPALQLIK TAPGFKLVSS VFFMLLPEQV VVYGDCAVNP NPTAEELADI
560 570 580 590 600
ALQSAASAQA LGIEPRVAML SYSTGDSGSG QEVEKVREAT RLARLARPDL
610 620 630 640 650
LIDGPLQYDA AAIASVGRQK APGSPVAGRA TVFIFPDLNT GNTTYKAVQR
660 670 680 690
SANVVSVGPM LQGLRKPVND LSRGASVEDI VYTIALTAVQ AASQR
Length:695
Mass (Da):74,998
Last modified:June 1, 2003 - v1
Checksum:i711FE70A7908EC5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA Translation: CAD84209.1
RefSeqiWP_011110933.1, NC_004757.1

Genome annotation databases

EnsemblBacteriaiCAD84209; CAD84209; NE0298
KEGGineu:NE0298

Similar proteinsi

Entry informationi

Entry nameiPTA_NITEU
AccessioniPrimary (citable) accession number: Q820S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health