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Q820M7

- SYL_NITEU

UniProt

Q820M7 - SYL_NITEU

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei627 – 6271ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-1162-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NE1139
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Leucine--tRNA ligasePRO_0000152055Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228410.NE1139.

Structurei

3D structure databases

ProteinModelPortaliQ820M7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi624 – 6285"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.
PhylomeDBiQ820M7.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q820M7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEKYHPQEI ERQARQSWQE TNIFNVTEIP DRPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLSRYRRMQG YNVMQPMGWD AFGLPAENAA IQKGVPPAKW
110 120 130 140 150
TYDNIAYMRS QLQSLGFAID WQRELATCDP QYYRWNQWLF LRMLEKGIAY
160 170 180 190 200
QKTQVVNWDP VDQTVLANEQ VIDGCGWRTG AVVEKREIPG YYLAITRYAD
210 220 230 240 250
ELLADLEKLP GWPERVKTMQ ANWIGKSFGV DITFPPDTAS GMPQALKVFT
260 270 280 290 300
TRADTLMGVT YVAVAAEHPV ALHAAHNQPD LVAFIESCRQ GATMEAELAV
310 320 330 340 350
QEKKGMATGL YVLHPLTGER LPVWVANYVL MSYGEGAVMA VPAHDERDFD
360 370 380 390 400
FARQHSLPIK PVIRPENGEL SVPLVQAFTE YGVTFNSDRF SDLTSPEAID
410 420 430 440 450
AIAVELGQKA LGEKRVRYRL RDWGISRQRY WGCPIPLIHC DSCGVVPVAD
460 470 480 490 500
DQLPVVLPED LVPDGSGNPL AKTPSFYECT CPRCGRQARR ETDTMDTFVD
510 520 530 540 550
SSWYFIRYAC PDQSAAMTDQ RANYWLPVDQ YIGGIEHAIL HLLYSRFWSK
560 570 580 590 600
VMRDLGLVSF DEPFANLLTQ GMVLNEIFFR KTSSGRIQYF NPAEVDVQHD
610 620 630 640 650
GEGKRVGAVL QADNQPVESG GIGTMSKSKN NGIDPQEIIE QYGADTARLF
660 670 680 690 700
MMFASPPTQT LEWSDAGVEG AFRFLKRLWR QVYLHRQLDG EAAATTTLVP
710 720 730 740 750
HQEYPADLRD LRCQLHQTIV KVTDDLERRH TFNTAIAAIM ELMNELSDVQ
760 770 780 790 800
GTHPAARQLM QEALENIVLL LSPIVPHICH VLWRELRPGT ELLDQPWPQA
810 820 830 840 850
DDQALIQDEV EIVVQINGKL RGQIRIAREA DRAAVERTAL QDEHIQKSIA
860
YRPVKRVIVV PGKLINIVV
Length:869
Mass (Da):98,496
Last modified:June 1, 2003 - v1
Checksum:i4A9387EE8921BC96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD85050.1.
RefSeqiNP_841196.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD85050; CAD85050; NE1139.
GeneIDi1082081.
KEGGineu:NE1139.
PATRICi22713322. VBINitEur56163_1262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD85050.1 .
RefSeqi NP_841196.1. NC_004757.1.

3D structure databases

ProteinModelPortali Q820M7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228410.NE1139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD85050 ; CAD85050 ; NE1139 .
GeneIDi 1082081.
KEGGi neu:NE1139.
PATRICi 22713322. VBINitEur56163_1262.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.
PhylomeDBi Q820M7.

Enzyme and pathway databases

BioCyci NEUR228410:GJNO-1162-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiSYL_NITEU
AccessioniPrimary (citable) accession number: Q820M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3