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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei627ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNEUR228410:G1G1I-1211-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NE1139
OrganismiNitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001416 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520551 – 869Leucine--tRNA ligaseAdd BLAST869

Proteomic databases

PRIDEiQ820M7

Interactioni

Protein-protein interaction databases

STRINGi228410.NE1139

Structurei

3D structure databases

ProteinModelPortaliQ820M7
SMRiQ820M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi624 – 628"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ
PhylomeDBiQ820M7

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q820M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEKYHPQEI ERQARQSWQE TNIFNVTEIP DRPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLSRYRRMQG YNVMQPMGWD AFGLPAENAA IQKGVPPAKW
110 120 130 140 150
TYDNIAYMRS QLQSLGFAID WQRELATCDP QYYRWNQWLF LRMLEKGIAY
160 170 180 190 200
QKTQVVNWDP VDQTVLANEQ VIDGCGWRTG AVVEKREIPG YYLAITRYAD
210 220 230 240 250
ELLADLEKLP GWPERVKTMQ ANWIGKSFGV DITFPPDTAS GMPQALKVFT
260 270 280 290 300
TRADTLMGVT YVAVAAEHPV ALHAAHNQPD LVAFIESCRQ GATMEAELAV
310 320 330 340 350
QEKKGMATGL YVLHPLTGER LPVWVANYVL MSYGEGAVMA VPAHDERDFD
360 370 380 390 400
FARQHSLPIK PVIRPENGEL SVPLVQAFTE YGVTFNSDRF SDLTSPEAID
410 420 430 440 450
AIAVELGQKA LGEKRVRYRL RDWGISRQRY WGCPIPLIHC DSCGVVPVAD
460 470 480 490 500
DQLPVVLPED LVPDGSGNPL AKTPSFYECT CPRCGRQARR ETDTMDTFVD
510 520 530 540 550
SSWYFIRYAC PDQSAAMTDQ RANYWLPVDQ YIGGIEHAIL HLLYSRFWSK
560 570 580 590 600
VMRDLGLVSF DEPFANLLTQ GMVLNEIFFR KTSSGRIQYF NPAEVDVQHD
610 620 630 640 650
GEGKRVGAVL QADNQPVESG GIGTMSKSKN NGIDPQEIIE QYGADTARLF
660 670 680 690 700
MMFASPPTQT LEWSDAGVEG AFRFLKRLWR QVYLHRQLDG EAAATTTLVP
710 720 730 740 750
HQEYPADLRD LRCQLHQTIV KVTDDLERRH TFNTAIAAIM ELMNELSDVQ
760 770 780 790 800
GTHPAARQLM QEALENIVLL LSPIVPHICH VLWRELRPGT ELLDQPWPQA
810 820 830 840 850
DDQALIQDEV EIVVQINGKL RGQIRIAREA DRAAVERTAL QDEHIQKSIA
860
YRPVKRVIVV PGKLINIVV
Length:869
Mass (Da):98,496
Last modified:June 1, 2003 - v1
Checksum:i4A9387EE8921BC96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA Translation: CAD85050.1
RefSeqiWP_011111730.1, NC_004757.1

Genome annotation databases

EnsemblBacteriaiCAD85050; CAD85050; NE1139
KEGGineu:NE1139

Similar proteinsi

Entry informationi

Entry nameiSYL_NITEU
AccessioniPrimary (citable) accession number: Q820M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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