Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q820E4 (TRMD_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (guanine-N(1)-)-methyltransferase
EC=2.1.1.228
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene names
Name:trmD
Ordered Locus Names:CCA_00656
OrganismChlamydophila caviae [Complete proteome] [HAMAP]
Taxonomic identifier83557 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates guanosine-37 in various tRNAs By similarity. HAMAP MF_00605

Catalytic activity

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA. HAMAP MF_00605

Subunit structure

Homodimer By similarity. HAMAP MF_00605

Subcellular location

Cytoplasm Potential HAMAP MF_00605.

Sequence similarities

Belongs to the RNA methyltransferase TrmD family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionRNA binding

Inferred from electronic annotation. Source: InterPro

tRNA (guanine-N1-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355tRNA (guanine-N(1)-)-methyltransferase HAMAP MF_00605
PRO_0000060357

Regions

Region129 – 1346S-adenosyl-L-methionine binding By similarity

Sites

Binding site1091S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q820E4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 61806B3B9729D6B8

FASTA35540,656
        10         20         30         40         50         60 
MEIEILSLFP DYFDSPLRSS ILGKAIKNGL LKIQSRDIRD FGLGKWKQVD DAPFNNDGML 

        70         80         90        100        110        120 
LMAEPVVQAI RHIKRSDSRV IHLSPQGKPL TAQKSRELAK CSHLIFLCGH YEGIDERALE 

       130        140        150        160        170        180 
SEVDEEISIG DYVLTNGGIA ALVVIDALSR FIPGVLGNQE SAEKDSLENG LLEGPQYTRP 

       190        200        210        220        230        240 
RVFEGKEVPE VLLQGDHQAV ARWRKQVSLD RTRERRPDLY IRYLYDRENE EVFPREEDTK 

       250        260        270        280        290        300 
QSTLEGESAV VLEVEDLQRS RKFYSKMFRL NQPSKDKLQI PGRTQMVLHL QEVGLKNKNT 

       310        320        330        340        350 
AILSLRLDCE DDFFSFLGRW KMLGGTLEQA DDHGTVRLVR DFDGHQWTIS YKKVK

« Hide

References

[1]"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. expand/collapse author list , Rank R.G., Bavoil P.M., Fraser C.M.
Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GPIC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015925 Genomic DNA. Translation: AAP05398.1.
RefSeqNP_829520.1. NC_003361.3.

3D structure databases

ProteinModelPortalQ820E4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1218341.
GenomeReviewsGene locus CCA_00656 in contig AE015925_GR.
KEGGcca:CCA00656.
PATRIC20270425. VBIChlCav107360_0699.
TIGRCCA_00656.

Phylogenomic databases

HOGENOMHBG285805.
OMARYLYDRE.
PhylomeDBQ820E4.
ProtClustDBPRK01037.

Enzyme and pathway databases

BioCycCCAV227941:CCA_00656-MONOMER.

Family and domain databases

HAMAPMF_00605. TrmD.
[Tree]
InterProIPR016009. tRNA_m1G_MeTrfase.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
[Graphical view]
Gene3DG3DSA:1.10.1270.20. tRNA_m1G_MeTrfase_C. 1 hit.
KOK00554.
PANTHERPTHR10056. PTHR10056. 1 hit.
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
TIGRFAMsTIGR00088. TrmD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRMD_CHLCV
AccessionPrimary (citable) accession number: Q820E4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents