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Protein

Apolipoprotein N-acyltransferase

Gene

lnt

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers the fatty acyl group on membrane lipoproteins.UniRule annotation

Pathwayi: lipoprotein biosynthesis (N-acyl transfer)

This protein is involved in the pathway lipoprotein biosynthesis (N-acyl transfer), which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipoprotein biosynthesis (N-acyl transfer) and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei259Proton acceptorPROSITE-ProRule annotation1
Active sitei317PROSITE-ProRule annotation1
Active sitei369NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Short name:
ALP N-acyltransferaseUniRule annotation
Gene namesi
Name:lntUniRule annotation
Ordered Locus Names:CBU_0564
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 37HelicalUniRule annotationAdd BLAST23
Transmembranei44 – 66HelicalUniRule annotationAdd BLAST23
Transmembranei76 – 98HelicalUniRule annotationAdd BLAST23
Transmembranei111 – 133HelicalUniRule annotationAdd BLAST23
Transmembranei157 – 179HelicalUniRule annotationAdd BLAST23
Transmembranei186 – 208HelicalUniRule annotationAdd BLAST23
Transmembranei467 – 484HelicalUniRule annotationAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001780611 – 485Apolipoprotein N-acyltransferaseAdd BLAST485

Proteomic databases

PRIDEiQ820B4.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0564.

Structurei

3D structure databases

ProteinModelPortaliQ820B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 457CN hydrolasePROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CE8. Bacteria.
COG0815. LUCA.
HOGENOMiHOG000264279.
KOiK03820.
OMAiPIGEFVP.

Family and domain databases

CDDicd07571. ALP_N-acyl_transferase. 1 hit.
Gene3Di3.60.110.10. 1 hit.
HAMAPiMF_01148. Lnt. 1 hit.
InterProiView protein in InterPro
IPR004563. Apolipo_AcylTrfase.
IPR003010. C-N_Hydrolase.
PfamiView protein in Pfam
PF00795. CN_hydrolase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
TIGRFAMsiTIGR00546. lnt. 1 hit.
PROSITEiView protein in PROSITE
PS50263. CN_HYDROLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q820B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSVLALIAG AILPLAFAPF NWFPIAFVSP AILLAVWLRS RPLVAWWRGW
60 70 80 90 100
LFGFGFFGAG ASWVYVSIHH FGNANVPLAV LITVLFVFVL ALFIAFQGLS
110 120 130 140 150
FSLFFRKRKA ALTALFAFPA WWVVWEWLRS ILFTGFPWLF LGYSQINSPL
160 170 180 190 200
KGFGPLFGIY GISLIVAFIS GCIYLLVTSK KLNKKIMCLI LIILPFIVGW
210 220 230 240 250
VLTFIPWTRP GSESVRVGLV QGNIGQRLKW DPDTLYSTLH TYYSETQKNW
260 270 280 290 300
DHGIIVWPEA AIPIYPQQVS VFLQALDKEA KQHNTALMTG IPIYHEKTNK
310 320 330 340 350
VFNGLMVLGD GHGLYLKRHL VPFGESFTSS KICNLLMKYF DIPMSDLSPG
360 370 380 390 400
PEDQEPTVVK GIPFAPFICY EIAYPTEVLN HLSNKQFIVV VNDDSWFAGT
410 420 430 440 450
IAPAQQLQIA QMRALETERY LLYSTNTGIT AIISPEGKIV KSAPQNQRLL
460 470 480
LTGQIKPVTG KTPLMRWNYY PVVGIIIIFL LLTFL
Length:485
Mass (Da):54,620
Last modified:June 1, 2003 - v1
Checksum:i4F46FAB283EFA343
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90108.1.
RefSeqiNP_819594.1. NC_002971.3.
WP_010957665.1. NC_002971.4.

Genome annotation databases

EnsemblBacteriaiAAO90108; AAO90108; CBU_0564.
GeneIDi1208449.
KEGGicbu:CBU_0564.
PATRICifig|227377.7.peg.558.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLNT_COXBU
AccessioniPrimary (citable) accession number: Q820B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families