Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-997-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:SA0943.1
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162207Add
BLAST

2D gel databases

SWISS-2DPAGEQ820A6.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliQ820A6.
SMRiQ820A6. Positions 8-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
KOiK00161.
OMAiLQYWGGD.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

Sequencei

Sequence statusi: Complete.

Q820A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKLQAQFD AVKVLNDTQS KFEMVQILDE NGNVVNEDLV PDLTDEQLVE
60 70 80 90 100
LMERMVWTRI LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALEKEDYI
110 120 130 140 150
LPGYRDVPQI IWHGLPLTEA FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY
160 170 180 190 200
IQAAGVAFAL KKRGKNAVAI TYTGDGGSSQ GDFYEGINFA AAYKAPAIFV
210 220 230 240 250
IQNNNYAIST PRSKQTAAET LAQKAIAVGI PGIQVDGMDA LAVYQATKEA
260 270 280 290 300
RDRAVAGEGP TLIETMTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR
310 320 330 340 350
FRKFLENKGL WNEDKENEVI ERAKADIKAA IKEADNTEKQ TVTSLMEIMY
360 370
EDMPQNLAEQ YEIYKEKESK
Length:370
Mass (Da):41,383
Last modified:June 1, 2003 - v1
Checksum:i66BD3BF8A0C9565F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAC55165.1.
RefSeqiWP_000035320.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAC55165; BAC55165; BAC55165.
GeneIDi23196870.
KEGGisau:SA0943-1.
PATRICi19574078. VBIStaAur116463_1009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAC55165.1.
RefSeqiWP_000035320.1. NC_002745.2.

3D structure databases

ProteinModelPortaliQ820A6.
SMRiQ820A6. Positions 8-370.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

SWISS-2DPAGEQ820A6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC55165; BAC55165; BAC55165.
GeneIDi23196870.
KEGGisau:SA0943-1.
PATRICi19574078. VBIStaAur116463_1009.

Phylogenomic databases

eggNOGiCOG1071.
KOiK00161.
OMAiLQYWGGD.
OrthoDBiEOG6VMTKR.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-997-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: N315.
  3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiODPA_STAAN
AccessioniPrimary (citable) accession number: Q820A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.