ID   Q81ZX0_STRAW            Unreviewed;       893 AA.
AC   Q81ZX0;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:BAC72718.1};
GN   Name=pkn19 {ECO:0000313|EMBL:BAC72718.1};
GN   ORFNames=SAVERM_5006 {ECO:0000313|EMBL:BAC72718.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC72718.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC72718.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC72718.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
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DR   EMBL; BA000030; BAC72718.1; -; Genomic_DNA.
DR   RefSeq; WP_010986411.1; NZ_JZJK01000077.1.
DR   AlphaFoldDB; Q81ZX0; -.
DR   KEGG; sma:SAVERM_5006; -.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_006299_0_0_11; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR45832; SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED; 1.
DR   PANTHER; PTHR45832:SF25; SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:BAC72718.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:BAC72718.1};
KW   Transferase {ECO:0000313|EMBL:BAC72718.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        657..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..587
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          208..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          625..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          679..751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        625..649
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        712..744
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   893 AA;  92763 MW;  CC4DA95AFAFE2407 CRC64;
     MDEYAGRVLA DRYRLPLPPS DEYELAETRA FDTYSGQEVL VRQVPLPEVV EAEVLDADGL
     PAGFVARDGG TRRASARTAT RRPAEPAVRR AIEAAQAAAQ IPDHPRLDQV FDVFAEGGSL
     WIVSELVAAR PLAALLADKP LSPYRAAEVA SDVLMALRVL HAHGWVHRNI TVRTVLVCDD
     GRVMLTGLAA GAAEEALCGY DPVPVRDFEP RGDDGGDGTG GNGRGAVRGA AAGGTPGIGS
     GPGAGSGRPG IGAGSGGPVG AAGGAVGAAA GGMSVAEAEA ARRAAIEARA GGVGPVAGTP
     GGEVPARGAR ALEGGGDARA QRAGAIAAYR AGARAAARVQ EAQRGGRAAL PAPRPADAEG
     RAPQSPGHGV EHLPGALPGQ IADPYGVART NSWPGGFPGD VGGANVGGAY GTPGNGSGTY
     ENGSVPHAPA DAPVSTPTPA DAVPPTHWDH LVSGSSAPSG PSAASVPRRG PTTALAAERA
     RQARMAVIGP VTERWAPEQA GPVHENWQLA APIGPATDLW ALGALLFRAV QGHAPYPEEN
     TAELVQLVCA EPPAFAEECG PLRPVVESLL RQDPTERLDF EEVRGWLRSL VRSAPEPEAG
     AHVVAAPPVD PRRLPIVRRR GELVRRRRAR LPATTPHARH KRAKDGRPPR PKRLGRNLVL
     LILLVLAAAV AYAMVFMPKA SPNSDSGSRS DGDRTGAAGG VSPAPEQSGG GSEPRPDQTS
     PGSGKSPSGS SGSTREQTTD PDVAQGFTLR KDPEGFRVAV ATGWDRAPKN GRGRIVYSHG
     DFELIVVPGR DSTADHGSDP LTYQRETESE LQPFRDSTWA TSSGMRRIDV GGRTMAEGQF
     TWTDGQGREL FVRNLAIVVG GRYHVVQLRG PEAERDEVTR LYEQASRTYQ VTG
//