ID   Q81ZW3_STRAW            Unreviewed;       834 AA.
AC   Q81ZW3;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=pkn26 {ECO:0000313|EMBL:BAC73087.1};
GN   ORFNames=SAVERM_5375 {ECO:0000313|EMBL:BAC73087.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC73087.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC73087.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC73087.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
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DR   EMBL; BA000030; BAC73087.1; -; Genomic_DNA.
DR   RefSeq; WP_010986778.1; NZ_JZJK01000066.1.
DR   AlphaFoldDB; Q81ZW3; -.
DR   KEGG; sma:SAVERM_5375; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_011707_0_0_11; -.
DR   OrthoDB; 137117at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR031634; PknG_rubred.
DR   InterPro; IPR031636; PknG_TPR.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR24363; SERINE/THREONINE PROTEIN KINASE; 1.
DR   PANTHER; PTHR24363:SF0; SERINE_THREONINE-PROTEIN KINASE DDB_G0277989-RELATED; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF16919; PknG_rubred; 1.
DR   Pfam; PF16918; PknG_TPR; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:BAC73087.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW   ECO:0000313|EMBL:BAC73087.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          193..481
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          46..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   834 AA;  89464 MW;  D89A39C7360F8D27 CRC64;
     MSEAQQKCQR PGCTGSYEDV GGGELYCDMC GLAPVVAAGG MVGSPATGIT GGGRGSRGSG
     SSSRASSRAS SRSSQSRRSV SGRLSRALSG KTSGRSVSVR SSGSTAGTSG RSRLGMGLVQ
     VPDVPRPDPR AMVLENPEVP ERKRFCSRSD CGAPVGRARG EHPGRTEGFC TKCGHPYSFV
     PKLHTGDVVH GQYEVVGCLA HGGLGWVYLA VDRAVSDRWV VLKGLLDTGD QDAMAAAISE
     RRFLAEIEHA NIVRIYNFVE HLDQRTGSLD GYIVMEYVGG KSLKEIANDR RTPTGKRDPL
     PVEQACAYGI EALEALGHLH SRNLLYCDFK VDNAIQTENQ LKLIDMGAVR RMDDEESAIY
     GTVGYQAPEV ADVGPSVASD LYTVARTLAV LTFDFQGYTN VFVDSLPDPD HIEVFRQYES
     FYRLLVRATD PDPVRRFASA QEMTEQLTGV LREVVSLQTG RARPALSTLF GPETKVTDTV
     LFAELEGDVS RLGARVVPVG KRGRAASTAS GVVPGRGTRT LVKPLDTAAA ALALPVPRVD
     PGDPNAGFLA GLMTSGPLEL VAALGNAPSP SVETRLRQIR ARLENGDSHT ALEVLAKLED
     ERPDDWRVVW YRGVAALVTG DHEVGALSFD AIYDAFPGEP APKLALGLCA EVLGQLDNAA
     EYYRLVWTTD PSYVGSAFGL ARVQLAAGDR RGAVRTLESV PESSIHYTAA RVAAVRARLR
     HRTNEAPEAS FLDDLGAAAG QVEALNGYGL DAVRREQLST EVLGCALDWV LSGSQGSAPP
     PDGGRALLGN ELDERGLRFG LERSYRTLAR LAQGGEERID LVERANRYRP RTWV
//