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Q81ZK3 (Q81ZK3_TROW8) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inorganic pyrophosphatase HAMAP MF_00209
EC=3.6.1.1 HAMAP MF_00209
Alternative name(s):
Pyrophosphate phospho-hydrolase HAMAP MF_00209
Gene names
Name:ppa1 HAMAP MF_00209 EMBL CAD67133.1
Synonyms:ppa2 EMBL CAD67282.1
Ordered Locus Names:TW465, TW618
OrganismTropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]
Taxonomic identifier218496 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP MF_00209

Cofactor

Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity. HAMAP MF_00209

Subcellular location

Cytoplasm By similarity HAMAP MF_00209.

Sequence similarities

Belongs to the PPase family. HAMAP MF_00209

Ontologies

Keywords
   Cellular componentCytoplasm HAMAP MF_00209
   LigandMagnesium HAMAP MF_00209
Metal-binding HAMAP MF_00209
   Molecular functionHydrolase HAMAP MF_00209 EMBL CAD67133.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphate-containing compound metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioninorganic diphosphatase activity

Inferred from electronic annotation. Source: HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q81ZK3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C5C2B850ECC344DA

FASTA15917,954
        10         20         30         40         50         60 
MQTLTAIVEI PRGSRSKYEI DKKTGRLFLD RVVSTAFGYP TNYGFIENTL ALDGDPIDAL 

        70         80         90        100        110        120 
ILVQNQLFPG VALHIRPVGV LHMTDDGGED DKVLCVALKD PYCDHINDLD DVPKHVLNQI 

       130        140        150 
EHFFQHYKDL EEGKWVKLGA WNGKDKAMEI ITEGLSRFN

« Hide

References

[1]"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei."
Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A.
Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX251411 Genomic DNA. Translation: CAD67133.1.
BX251412 Genomic DNA. Translation: CAD67282.1.
RefSeqNP_789395.1. NC_004551.1.
NP_789544.1. NC_004551.1.

3D structure databases

HSSPHSSP built from PDB template 1FAJ based on UniProtKB P17288.
ProteinModelPortalQ81ZK3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ81ZK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1064306.
1064823.
GenomeReviewsGene locus TW465 in contig BX072543_GR.
Gene locus TW618 in contig BX072543_GR.
KEGGtws:TW465.
tws:TW618.
PATRIC23999415. VBITroWhi42739_0533.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0221.
HOGENOMHBG529150.
OMAYGFFENT.
PhylomeDBQ81ZK3.
ProtClustDBCLSK229788.

Enzyme and pathway databases

BioCycTWHI218496:TW0440-MONOMER.
TWHI218496:TW0589-MONOMER.

Family and domain databases

HAMAPMF_00209. Inorganic_PPase.
[Tree]
InterProIPR008162. Pyrophosphatase.
[Graphical view]
Gene3DG3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
KOK01507.
PANTHERPTHR10286. Pyrophosphatase. 1 hit.
PfamPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMSSF50324. Pyrophosphatase. 1 hit.
PROSITEPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ81ZK3_TROW8
AccessionPrimary (citable) accession number: Q81ZK3
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info