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Q81ZH8

- Q81ZH8_BACAN

UniProt

Q81ZH8 - Q81ZH8_BACAN

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Protein

N5-carboxyaminoimidazole ribonucleotide mutase

Gene

purE

Organism
Bacillus anthracis
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation

Catalytic activityi

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Acetate 1; via carbonyl oxygenImported
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei14 – 141Acetate 2Imported
Binding sitei14 – 141SubstrateUniRule annotation
Binding sitei41 – 411SubstrateUniRule annotation
Binding sitei66 – 661Acetate 2; via amide nitrogenImported
Binding sitei94 – 941Acetate 4Imported

GO - Molecular functioni

  1. 5-(carboxyamino)imidazole ribonucleotide mutase activity Source: UniProtKB-EC
  2. lyase activity Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation, LyaseImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciANTHRA:PURE-MONOMER.
BANT260799:GJAJ-317-MONOMER.
BANT261594:GJ7F-326-MONOMER.
UniPathwayiUPA00074; UER00943.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)
Short name:
N5-CAIR mutaseUniRule annotation
Gene namesi
Name:purEImported
Ordered Locus Names:BA_0288Imported, BAS0275Imported, GBAA_0288Imported
ORF Names:BACvac02_0349Imported, BAHan_0354Imported, DJ42_4802Imported, DJ43_4834Imported, DJ44_4148Imported, DJ45_5599Imported, DJ48_3919Imported, DJ49_5206Imported, HYU01_01580Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_0288.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XMPX-ray1.80A/B/C/D/E/F/G/H1-161[»]
4AY3X-ray1.76A/B/C/D1-161[»]
4AY4X-ray2.00A/B/C/D1-161[»]
4B4KX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-161[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81ZH8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 414Acetate 1 bindingImported
Regioni38 – 414Acetate 3 bindingImported

Sequence similaritiesi

Belongs to the AIR carboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000034141.
KOiK01588.
OMAiKHACDIL.
OrthoDBiEOG6Z0QH2.

Family and domain databases

Gene3Di3.40.50.7700. 1 hit.
InterProiIPR024694. N5-CAIR_mutase_PurE.
IPR000031. PurE_dom.
[Graphical view]
PfamiPF00731. AIRC. 1 hit.
[Graphical view]
PIRSFiPIRSF001338. AIR_carboxylase. 1 hit.
SMARTiSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMiSSF52255. SSF52255. 1 hit.
TIGRFAMsiTIGR01162. purE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81ZH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSLVGVIMG STSDWETMKY ACDILDELNI PYEKKVVSAH RTPDYMFEYA
60 70 80 90 100
ETARERGLKV IIAGAGGAAH LPGMVAAKTN LPVIGVPVQS KALNGLDSLL
110 120 130 140 150
SIVQMPGGVP VATVAIGKAG STNAGLLAAQ ILGSFHDDIH DALELRREAI
160
EKDVREGSEL V
Length:161
Mass (Da):17,042
Last modified:June 1, 2003 - v1
Checksum:i6BC2A80C2A91A94E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP24324.1.
AE017334 Genomic DNA. Translation: AAT29375.1.
AE017225 Genomic DNA. Translation: AAT52606.1.
CP008846 Genomic DNA. Translation: AIF54757.1.
CP007618 Genomic DNA. Translation: AIK30710.1.
CP008752 Genomic DNA. Translation: AIK50938.1.
CP007704 Genomic DNA. Translation: AIK60423.1.
CP008853 Genomic DNA. Translation: AIM04255.1.
CP008854 Genomic DNA. Translation: AIM09640.1.
JNOD01000011 Genomic DNA. Translation: KFJ82979.1.
JMPV01000005 Genomic DNA. Translation: KFL76696.1.
JMPU01000011 Genomic DNA. Translation: KFL79633.1.
RefSeqiNP_842838.1. NC_003997.3.
YP_016900.1. NC_007530.2.
YP_026555.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24324; AAP24324; BA_0288.
AAT29375; AAT29375; GBAA_0288.
AAT52606; AAT52606; BAS0275.
GeneIDi1085644.
2817097.
2851322.
KEGGiban:BA_0288.
bar:GBAA_0288.
bat:BAS0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP24324.1 .
AE017334 Genomic DNA. Translation: AAT29375.1 .
AE017225 Genomic DNA. Translation: AAT52606.1 .
CP008846 Genomic DNA. Translation: AIF54757.1 .
CP007618 Genomic DNA. Translation: AIK30710.1 .
CP008752 Genomic DNA. Translation: AIK50938.1 .
CP007704 Genomic DNA. Translation: AIK60423.1 .
CP008853 Genomic DNA. Translation: AIM04255.1 .
CP008854 Genomic DNA. Translation: AIM09640.1 .
JNOD01000011 Genomic DNA. Translation: KFJ82979.1 .
JMPV01000005 Genomic DNA. Translation: KFL76696.1 .
JMPU01000011 Genomic DNA. Translation: KFL79633.1 .
RefSeqi NP_842838.1. NC_003997.3.
YP_016900.1. NC_007530.2.
YP_026555.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XMP X-ray 1.80 A/B/C/D/E/F/G/H 1-161 [» ]
4AY3 X-ray 1.76 A/B/C/D 1-161 [» ]
4AY4 X-ray 2.00 A/B/C/D 1-161 [» ]
4B4K X-ray 2.50 A/B/C/D/E/F/G/H/I/J/K/L 1-161 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_0288.

Protocols and materials databases

DNASUi 1085644.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP24324 ; AAP24324 ; BA_0288 .
AAT29375 ; AAT29375 ; GBAA_0288 .
AAT52606 ; AAT52606 ; BAS0275 .
GeneIDi 1085644.
2817097.
2851322.
KEGGi ban:BA_0288.
bar:GBAA_0288.
bat:BAS0275.

Phylogenomic databases

HOGENOMi HOG000034141.
KOi K01588.
OMAi KHACDIL.
OrthoDBi EOG6Z0QH2.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00943 .
BioCyci ANTHRA:PURE-MONOMER.
BANT260799:GJAJ-317-MONOMER.
BANT261594:GJ7F-326-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81ZH8.

Family and domain databases

Gene3Di 3.40.50.7700. 1 hit.
InterProi IPR024694. N5-CAIR_mutase_PurE.
IPR000031. PurE_dom.
[Graphical view ]
Pfami PF00731. AIRC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001338. AIR_carboxylase. 1 hit.
SMARTi SM01001. AIRC. 1 hit.
[Graphical view ]
SUPFAMi SSF52255. SSF52255. 1 hit.
TIGRFAMsi TIGR01162. purE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate PortonImported.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SterneImported.
  3. "Crystal structure of PurE (BA0288) from Bacillus anthracis at 1.8 A resolution."
    Boyle M.P., Kalliomaa A.K., Levdikov V., Blagova E., Fogg M.J., Brannigan J.A., Wilson K.S., Wilkinson A.J.
    Proteins 61:674-676(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames AncestorImported and Ames ancestorImported.
  5. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  6. "Elastic and inelastic diffraction changes upon variation of the relative humidity environment of PurE crystals."
    Oliete R., Pous J., Rodriguez-Puente S., Abad-Zapatero C., Guasch A.
    Acta Crystallogr. D 69:194-212(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS).
  7. Tong Y.G., Huang Y., An X.P., Li S.S., Mi Z.Q., Pei G.Q., Zhang Z.Y., Fan H.
    Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Cvac02Imported and HanImported.
  8. "Complete Genome Sequence of Bacillus anthracis HYU01, Isolated from Soil Samples in the Korean Peninsula."
    Kim S.K., Chung W.H., Kim S.H., Jung K.H., Kim N., Chai Y.G.
    Genome Announc. 2:e00769-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HYU01Imported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031021Imported, A.Br.003Imported, Smith 1013Imported and Zimbabwe 89Imported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BFVImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Delta SterneImported.

Entry informationi

Entry nameiQ81ZH8_BACAN
AccessioniPrimary (citable) accession number: Q81ZH8
Secondary accession number(s): E9RB02
, E9RB03, Q6I4C5, Q6KY27
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3