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Q81ZH8

- Q81ZH8_BACAN

UniProt

Q81ZH8 - Q81ZH8_BACAN

Protein

N5-carboxyaminoimidazole ribonucleotide mutase

Gene

purE

Organism
Bacillus anthracis
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation

    Catalytic activityi

    5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101Acetate 1; via carbonyl oxygenImported
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei14 – 141Acetate 2Imported
    Binding sitei14 – 141SubstrateUniRule annotation
    Binding sitei41 – 411SubstrateUniRule annotation
    Binding sitei66 – 661Acetate 2; via amide nitrogenImported
    Binding sitei94 – 941Acetate 4Imported

    GO - Molecular functioni

    1. 5-(carboxyamino)imidazole ribonucleotide mutase activity Source: UniProtKB-EC
    2. lyase activity Source: UniProtKB-KW

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotation, LyaseImported

    Keywords - Biological processi

    Purine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciANTHRA:PURE-MONOMER.
    BANT260799:GJAJ-317-MONOMER.
    BANT261594:GJ7F-326-MONOMER.
    UniPathwayiUPA00074; UER00943.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)
    Short name:
    N5-CAIR mutaseUniRule annotation
    Gene namesi
    Name:purEImported
    Ordered Locus Names:BA_0288Imported, BAS0275Imported, GBAA_0288Imported
    OrganismiBacillus anthracisImported
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000005639: Chromosome, UP000000594: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi198094.BA_0288.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XMPX-ray1.80A/B/C/D/E/F/G/H1-161[»]
    4AY3X-ray1.76A/B/C/D1-161[»]
    4AY4X-ray2.00A/B/C/D1-161[»]
    4B4KX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-161[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ81ZH8.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni38 – 414Acetate 1 bindingImported
    Regioni38 – 414Acetate 3 bindingImported

    Sequence similaritiesi

    Belongs to the AIR carboxylase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000034141.
    KOiK01588.
    OMAiKHACDIL.
    OrthoDBiEOG6Z0QH2.

    Family and domain databases

    Gene3Di3.40.50.7700. 1 hit.
    InterProiIPR024694. N5-CAIR_mutase_PurE.
    IPR000031. PurE_dom.
    [Graphical view]
    PfamiPF00731. AIRC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001338. AIR_carboxylase. 1 hit.
    SMARTiSM01001. AIRC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52255. SSF52255. 1 hit.
    TIGRFAMsiTIGR01162. purE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q81ZH8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLVGVIMG STSDWETMKY ACDILDELNI PYEKKVVSAH RTPDYMFEYA    50
    ETARERGLKV IIAGAGGAAH LPGMVAAKTN LPVIGVPVQS KALNGLDSLL 100
    SIVQMPGGVP VATVAIGKAG STNAGLLAAQ ILGSFHDDIH DALELRREAI 150
    EKDVREGSEL V 161
    Length:161
    Mass (Da):17,042
    Last modified:June 1, 2003 - v1
    Checksum:i6BC2A80C2A91A94E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP24324.1.
    AE017334 Genomic DNA. Translation: AAT29375.1.
    AE017225 Genomic DNA. Translation: AAT52606.1.
    RefSeqiNP_842838.1. NC_003997.3.
    YP_016900.1. NC_007530.2.
    YP_026555.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP24324; AAP24324; BA_0288.
    AAT29375; AAT29375; GBAA_0288.
    AAT52606; AAT52606; BAS0275.
    GeneIDi1085644.
    2817097.
    2851322.
    KEGGiban:BA_0288.
    bar:GBAA_0288.
    bat:BAS0275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP24324.1 .
    AE017334 Genomic DNA. Translation: AAT29375.1 .
    AE017225 Genomic DNA. Translation: AAT52606.1 .
    RefSeqi NP_842838.1. NC_003997.3.
    YP_016900.1. NC_007530.2.
    YP_026555.1. NC_005945.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XMP X-ray 1.80 A/B/C/D/E/F/G/H 1-161 [» ]
    4AY3 X-ray 1.76 A/B/C/D 1-161 [» ]
    4AY4 X-ray 2.00 A/B/C/D 1-161 [» ]
    4B4K X-ray 2.50 A/B/C/D/E/F/G/H/I/J/K/L 1-161 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_0288.

    Protocols and materials databases

    DNASUi 1085644.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP24324 ; AAP24324 ; BA_0288 .
    AAT29375 ; AAT29375 ; GBAA_0288 .
    AAT52606 ; AAT52606 ; BAS0275 .
    GeneIDi 1085644.
    2817097.
    2851322.
    KEGGi ban:BA_0288.
    bar:GBAA_0288.
    bat:BAS0275.

    Phylogenomic databases

    HOGENOMi HOG000034141.
    KOi K01588.
    OMAi KHACDIL.
    OrthoDBi EOG6Z0QH2.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00943 .
    BioCyci ANTHRA:PURE-MONOMER.
    BANT260799:GJAJ-317-MONOMER.
    BANT261594:GJ7F-326-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q81ZH8.

    Family and domain databases

    Gene3Di 3.40.50.7700. 1 hit.
    InterProi IPR024694. N5-CAIR_mutase_PurE.
    IPR000031. PurE_dom.
    [Graphical view ]
    Pfami PF00731. AIRC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001338. AIR_carboxylase. 1 hit.
    SMARTi SM01001. AIRC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52255. SSF52255. 1 hit.
    TIGRFAMsi TIGR01162. purE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AmesImported and Ames ancestor.
    2. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SterneImported.
    3. "Crystal structure of PurE (BA0288) from Bacillus anthracis at 1.8 A resolution."
      Boyle M.P., Kalliomaa A.K., Levdikov V., Blagova E., Fogg M.J., Brannigan J.A., Wilson K.S., Wilkinson A.J.
      Proteins 61:674-676(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate PortonImported, Ames AncestorImported, Ames ancestorImported and Sterne.
    5. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AmesImported.
    6. "Elastic and inelastic diffraction changes upon variation of the relative humidity environment of PurE crystals."
      Oliete R., Pous J., Rodriguez-Puente S., Abad-Zapatero C., Guasch A.
      Acta Crystallogr. D 69:194-212(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS).

    Entry informationi

    Entry nameiQ81ZH8_BACAN
    AccessioniPrimary (citable) accession number: Q81ZH8
    Secondary accession number(s): E9RB02
    , E9RB03, Q6I4C5, Q6KY27
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3