Q81ZH8 (Q81ZH8_BACAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutase PIRNR PIRNR001338
Short name=N5-CAIR mutase PIRNR PIRNR001338
EC=5.4.99.18 PIRNR PIRNR001338

Gene names

Name:	purE EMBL AAP24324.1
Ordered Locus Names:	BA_0288, BAS0275, GBAA_0288 EMBL AAT29375.1

Organism

Bacillus anthracis

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity. PIRNR PIRNR001338
Catalytic activity	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. PIRNR PIRNR001338
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. PIRNR PIRNR001338
Sequence similarities	Belongs to the AIR carboxylase family. PIRNR PIRNR001338

Ontologies

Keywords
Biological process	Purine biosynthesis PIRNR PIRNR001338
Molecular function	Isomerase PIRNR PIRNR001338 Lyase EMBL AAP24324.1
Technical term	3D-structure PDB 1XMP Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: EC phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q81ZH8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 6BC2A80C2A91A94E	FASTA	161	17,042
	10 20 30 40 50 60 MKSLVGVIMG STSDWETMKY ACDILDELNI PYEKKVVSAH RTPDYMFEYA ETARERGLKV 70 80 90 100 110 120 IIAGAGGAAH LPGMVAAKTN LPVIGVPVQS KALNGLDSLL SIVQMPGGVP VATVAIGKAG 130 140 150 160 STNAGLLAAQ ILGSFHDDIH DALELRREAI EKDVREGSEL V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Crystal structure of PurE (BA0288) from Bacillus anthracis at 1.8 A resolution." Boyle M.P., Kalliomaa A.K., Levdikov V., Blagova E., Fogg M.J., Brannigan J.A., Wilson K.S., Wilkinson A.J. Proteins 61:674-676(2005) [PubMed: 16138311] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.
[4]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016879 Genomic DNA. Translation: AAP24324.1.
AE017334 Genomic DNA. Translation: AAT29375.1.
AE017225 Genomic DNA. Translation: AAT52606.1.

RefSeq

NP_842838.1. NC_003997.3.
YP_016900.1. NC_007530.2.
YP_026555.1. NC_005945.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XMP	X-ray	1.80	A/B/C/D/E/F/G/H	1-161	[»]

ProteinModelPortal

Q81ZH8.

SMR

Q81ZH8. Positions 2-161.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q81ZH8. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBBACT00000009228; EBBACP00000008984; EBBACG00000009220.
EBBACT00000014663; EBBACP00000014284; EBBACG00000014655.
EBBACT00000023973; EBBACP00000023458; EBBACG00000023964.

GeneID

1085644.
2817097.
2851322.

GenomeReviews

Gene locus BA_0288 in contig AE016879_GR.
Gene locus BAS0275 in contig AE017225_GR.
Gene locus GBAA_0288 in contig AE017334_GR.

KEGG

ban:BA_0288.
bar:GBAA_0288.
bat:BAS0275.

TIGR

BA_0288.
GBAA0288.

Phylogenomic databases

GeneTree

EBGT00050000002990.

HOGENOM

HBG301965.

OMA

LIMGSDS.

ProtClustDB

CLSK915770.

Family and domain databases

InterPro

IPR024694. N5-CAIR_mutase_PurE.
IPR000031. N5-CAIR_Mutase_PurE_dom.
[Graphical view]

Gene3D

G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.

KO

K01588.

Pfam

PF00731. AIRC. 1 hit.
[Graphical view]

PIRSF

PIRSF001338. AIR_carboxylase. 1 hit.

SMART

SM01001. AIRC. 1 hit.
[Graphical view]

SUPFAM

SSF52255. AIR_carboxyl. 1 hit.

TIGRFAMs

TIGR01162. PurE. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q81ZH8_BACAN

Accession

Primary (citable) accession number: Q81ZH8
Secondary accession number(s): E9RB02 , E9RB03, Q6I4C5, Q6KY27

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)