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Q81ZH8 (Q81ZH8_BACAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N5-carboxyaminoimidazole ribonucleotide mutase PIRNR PIRNR001338

Short name=N5-CAIR mutase PIRNR PIRNR001338
EC=5.4.99.18 PIRNR PIRNR001338
Gene names
Name:purE EMBL AAP24324.1
Ordered Locus Names:BA_0288 EMBL AAP24324.1, BAS0275 EMBL AAT52606.1, GBAA_0288 EMBL AAT29375.1
OrganismBacillus anthracis [Reference proteome] [HAMAP]
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity. PIRNR PIRNR001338

Catalytic activity

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. PIRNR PIRNR001338

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. PIRNR PIRNR001338

Sequence similarities

Belongs to the AIR carboxylase family. PIRNR PIRNR001338

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region38 – 414Acetate 1 binding PDB 4AY4 PDB 4AY3
Region38 – 414Acetate 3 binding PDB 4AY3

Sites

Binding site101Acetate 1; via carbonyl oxygen PDB 4AY4 PDB 4AY3
Binding site111Substrate By similarity PIRSR PIRSR001338-1
Binding site141Acetate 2 PDB 4AY3
Binding site141Substrate By similarity PIRSR PIRSR001338-1
Binding site411Substrate By similarity PIRSR PIRSR001338-1
Binding site661Acetate 2; via amide nitrogen PDB 4AY3
Binding site941Acetate 4 PDB 4AY4

Sequences

Sequence LengthMass (Da)Tools
Q81ZH8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6BC2A80C2A91A94E

FASTA16117,042
        10         20         30         40         50         60 
MKSLVGVIMG STSDWETMKY ACDILDELNI PYEKKVVSAH RTPDYMFEYA ETARERGLKV 

        70         80         90        100        110        120 
IIAGAGGAAH LPGMVAAKTN LPVIGVPVQS KALNGLDSLL SIVQMPGGVP VATVAIGKAG 

       130        140        150        160 
STNAGLLAAQ ILGSFHDDIH DALELRREAI EKDVREGSEL V 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
Read T.D., Peterson S.N., Tourasse N., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. expand/collapse author list , Brinkac L.M., Gwinn M., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolsto A.B., Fraser C.M.
Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames EMBL AAP24324.1 and Ames / isolate Porton.
[2]"Complete genome sequence of Bacillus anthracis Sterne."
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sterne EMBL AAT52606.1.
[3]"Crystal structure of PurE (BA0288) from Bacillus anthracis at 1.8 A resolution."
Boyle M.P., Kalliomaa A.K., Levdikov V., Blagova E., Fogg M.J., Brannigan J.A., Wilson K.S., Wilkinson A.J.
Proteins 61:674-676(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
[4]"The complete genome sequence of Bacillus anthracis Ames 'Ancestor'."
Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.
J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor and Ames Ancestor EMBL AAT29375.1.
[5]Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Ames EMBL AAP24324.1.
[6]"Elastic and inelastic diffraction changes upon variation of the relative humidity environment of PurE crystals."
Oliete R., Pous J., Rodriguez-Puente S., Abad-Zapatero C., Guasch A.
Acta Crystallogr. D 69:194-212(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) IN COMPLEX WITH ACETATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016879 Genomic DNA. Translation: AAP24324.1.
AE017334 Genomic DNA. Translation: AAT29375.1.
AE017225 Genomic DNA. Translation: AAT52606.1.
RefSeqNP_842838.1. NC_003997.3.
YP_016900.1. NC_007530.2.
YP_026555.1. NC_005945.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XMPX-ray1.80A/B/C/D/E/F/G/H1-161[»]
4AY3X-ray1.76A/B/C/D1-161[»]
4AY4X-ray2.00A/B/C/D1-161[»]
4B4KX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-161[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198094.BA_0288.

Protocols and materials databases

DNASU1085644.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP24324; AAP24324; BA_0288.
AAT29375; AAT29375; GBAA_0288.
AAT52606; AAT52606; BAS0275.
GeneID1085644.
2817097.
2851322.
KEGGban:BA_0288.
bar:GBAA_0288.
bat:BAS0275.

Phylogenomic databases

HOGENOMHOG000034141.
KOK01588.
OMAKQVISAH.
OrthoDBEOG6Z0QH2.
ProtClustDBCLSK915770.

Enzyme and pathway databases

BioCycANTHRA:PURE-MONOMER.
BANT260799:GJAJ-317-MONOMER.
BANT261594:GJ7F-326-MONOMER.
UniPathwayUPA00074; UER00943.

Family and domain databases

Gene3D3.40.50.7700. 1 hit.
InterProIPR024694. N5-CAIR_mutase_PurE.
IPR000031. PurE_dom.
[Graphical view]
PfamPF00731. AIRC. 1 hit.
[Graphical view]
PIRSFPIRSF001338. AIR_carboxylase. 1 hit.
SMARTSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMSSF52255. SSF52255. 1 hit.
TIGRFAMsTIGR01162. purE. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ81ZH8.

Entry information

Entry nameQ81ZH8_BACAN
AccessionPrimary (citable) accession number: Q81ZH8
Secondary accession number(s): E9RB02 expand/collapse secondary AC list , E9RB03, Q6I4C5, Q6KY27
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)