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Protein

N5-carboxyaminoimidazole ribonucleotide mutase

Gene

purE

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation

Catalytic activityi

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK), N5-carboxyaminoimidazole ribonucleotide synthase (purK)
  2. N5-carboxyaminoimidazole ribonucleotide mutase (purE), N5-carboxyaminoimidazole ribonucleotide mutase (purE), N5-carboxyaminoimidazole ribonucleotide mutase (purE), N5-carboxyaminoimidazole ribonucleotide mutase (purE), N5-carboxyaminoimidazole ribonucleotide mutase (purE)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateUniRule annotation1
Binding sitei14SubstrateUniRule annotation1
Binding sitei41SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation, LyaseImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00943

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)
Short name:
N5-CAIR mutaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutaseUniRule annotation
Gene namesi
Name:purEUniRule annotationImported
Ordered Locus Names:GBAA_0288Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

IntActiQ81ZH8, 2 interactors
STRINGi260799.BAS0275

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMPX-ray1.80A/B/C/D/E/F/G/H1-161[»]
4AY3X-ray1.76A/B/C/D1-161[»]
4AY4X-ray2.00A/B/C/D1-161[»]
4B4KX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-161[»]
SMRiQ81ZH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR carboxylase family. Class I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UM6 Bacteria
COG0041 LUCA
HOGENOMiHOG000034141
KOiK01588
OMAiSNSIDGW

Family and domain databases

Gene3Di3.40.50.7700, 1 hit
HAMAPiMF_01929 PurE_classI, 1 hit
InterProiView protein in InterPro
IPR033747 PurE_ClassI
IPR000031 PurE_dom
IPR024694 PurE_prokaryotes
IPR035893 PurE_sf
PfamiView protein in Pfam
PF00731 AIRC, 1 hit
PIRSFiPIRSF001338 AIR_carboxylase, 1 hit
SMARTiView protein in SMART
SM01001 AIRC, 1 hit
SUPFAMiSSF52255 SSF52255, 1 hit
TIGRFAMsiTIGR01162 purE, 1 hit

Sequencei

Sequence statusi: Complete.

Q81ZH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLVGVIMG STSDWETMKY ACDILDELNI PYEKKVVSAH RTPDYMFEYA
60 70 80 90 100
ETARERGLKV IIAGAGGAAH LPGMVAAKTN LPVIGVPVQS KALNGLDSLL
110 120 130 140 150
SIVQMPGGVP VATVAIGKAG STNAGLLAAQ ILGSFHDDIH DALELRREAI
160
EKDVREGSEL V
Length:161
Mass (Da):17,042
Last modified:June 1, 2003 - v1
Checksum:i6BC2A80C2A91A94E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA Translation: AAT29375.1
RefSeqiWP_000839367.1, NZ_NVMW01000047.1

Genome annotation databases

EnsemblBacteriaiAAT29375; AAT29375; GBAA_0288
ANH84698; ANH84698; A8C77_01635
KLV16365; KLV16365; ABW01_20895
GeneIDi29682245
KEGGibar:GBAA_0288
PATRICifig|1392.230.peg.275

Similar proteinsi

Entry informationi

Entry nameiQ81ZH8_BACAN
AccessioniPrimary (citable) accession number: Q81ZH8
Secondary accession number(s): E9RB02
, E9RB03, Q6I4C5, Q6KY27
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health