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Q81ZH6

- Q81ZH6_BACAN

UniProt

Q81ZH6 - Q81ZH6_BACAN

Protein

Adenylosuccinate lyase

Gene

purB

Organism
Bacillus anthracis
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC
    2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. purine ribonucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationImported

    Keywords - Biological processi

    Purine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciANTHRA:PURB-MONOMER.
    BANT260799:GJAJ-319-MONOMER.
    BANT261594:GJ7F-328-MONOMER.
    UniPathwayiUPA00074; UER00132.
    UPA00075; UER00336.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
    Short name:
    ASLUniRule annotation
    Alternative name(s):
    AdenylosuccinaseUniRule annotation
    Gene namesi
    Name:purBImported
    Ordered Locus Names:BA_0290Imported, BAS0277Imported, GBAA_0290Imported
    OrganismiBacillus anthracisImported
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000594: Chromosome, UP000005639: Chromosome, UP000000427: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi198094.BA_0290.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PFMX-ray2.00A/B1-435[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ81ZH6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000033912.
    KOiK01756.
    OMAiERIIEDK.
    OrthoDBiEOG686NDB.

    Family and domain databases

    Gene3Di1.10.275.10. 1 hit.
    InterProiIPR019468. AdenyloSucc_lyase_C.
    IPR024083. Fumarase/histidase_N.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    IPR004769. Pur_lyase.
    [Graphical view]
    PANTHERiPTHR11444. PTHR11444. 1 hit.
    PfamiPF10397. ADSL_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view]
    PRINTSiPR00149. FUMRATELYASE.
    SMARTiSM00998. ADSL_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48557. SSF48557. 1 hit.
    TIGRFAMsiTIGR00928. purB. 1 hit.
    PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81ZH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISRYTRPEM GAIWTEENKF KAWLEVEILA CEAWAELGDI PKEDVKKIRE    50
    HASFDIDRIY EIEKETRHDV VAFTRAVSET PALGEERKWV HYGLTSTDVV 100
    DTALSYILKQ ANEIILKDLE NFVSILANKA KEHKYTIMMG RTHGVHAEPT 150
    TFGLKLGLWY EEMKRNVERF KQAANTVRVG KLSGAVGTYA NIDPFVEKYV 200
    CENLGLEAAP ISTQTLQRDR HAHYMSTLAL IATSIEKMAV EIRGLQKSET 250
    REVEEAFAKG QKGSSAMPHK RNPIGSENMT GLARVIRGYM MTAYENVPLW 300
    HERDISHSSA ERVILPDATI ALNYMLNRFG NIVKNLTVYP ENMKRNMTRT 350
    YGLIYSQRVM LTLIDKGMVR EEAYDIVQPK AMEAWETQVQ FKELVEADER 400
    ITSKLTQEEI NECFNYEHHM QHVDTIFERL GLNEA 435
    Length:435
    Mass (Da):49,988
    Last modified:June 1, 2003 - v1
    Checksum:i772B8EB811E0CB98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP24326.1.
    AE017334 Genomic DNA. Translation: AAT29377.1.
    AE017225 Genomic DNA. Translation: AAT52608.1.
    RefSeqiNP_842840.1. NC_003997.3.
    YP_016902.1. NC_007530.2.
    YP_026557.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP24326; AAP24326; BA_0290.
    AAT29377; AAT29377; GBAA_0290.
    AAT52608; AAT52608; BAS0277.
    GeneIDi1085703.
    2819273.
    2850059.
    KEGGiban:BA_0290.
    bar:GBAA_0290.
    bat:BAS0277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP24326.1 .
    AE017334 Genomic DNA. Translation: AAT29377.1 .
    AE017225 Genomic DNA. Translation: AAT52608.1 .
    RefSeqi NP_842840.1. NC_003997.3.
    YP_016902.1. NC_007530.2.
    YP_026557.1. NC_005945.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PFM X-ray 2.00 A/B 1-435 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_0290.

    Protocols and materials databases

    DNASUi 1085703.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP24326 ; AAP24326 ; BA_0290 .
    AAT29377 ; AAT29377 ; GBAA_0290 .
    AAT52608 ; AAT52608 ; BAS0277 .
    GeneIDi 1085703.
    2819273.
    2850059.
    KEGGi ban:BA_0290.
    bar:GBAA_0290.
    bat:BAS0277.

    Phylogenomic databases

    HOGENOMi HOG000033912.
    KOi K01756.
    OMAi ERIIEDK.
    OrthoDBi EOG686NDB.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00132 .
    UPA00075 ; UER00336 .
    BioCyci ANTHRA:PURB-MONOMER.
    BANT260799:GJAJ-319-MONOMER.
    BANT261594:GJ7F-328-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q81ZH6.

    Family and domain databases

    Gene3Di 1.10.275.10. 1 hit.
    InterProi IPR019468. AdenyloSucc_lyase_C.
    IPR024083. Fumarase/histidase_N.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    IPR004769. Pur_lyase.
    [Graphical view ]
    PANTHERi PTHR11444. PTHR11444. 1 hit.
    Pfami PF10397. ADSL_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00149. FUMRATELYASE.
    SMARTi SM00998. ADSL_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48557. SSF48557. 1 hit.
    TIGRFAMsi TIGR00928. purB. 1 hit.
    PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AmesImported, Ames ancestor and Sterne.
    2. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Crystal Structure of Adenylosuccinate Lyase (PurB) from Bacillus anthracis."
      Levdikov V.M., Blagova E.V., Wilkinson A.J., Wilson K.S.
      Submitted (APR-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate PortonImported, Ames ancestorImported, Ames AncestorImported and SterneImported.
    5. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AmesImported.

    Entry informationi

    Entry nameiQ81ZH6_BACAN
    AccessioniPrimary (citable) accession number: Q81ZH6
    Secondary accession number(s): E9RC82
    , E9RC83, Q6I4C3, Q6KY25
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3