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Q81ZH6

- Q81ZH6_BACAN

UniProt

Q81ZH6 - Q81ZH6_BACAN

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Protein

Adenylosuccinate lyase

Gene

purB

Organism
Bacillus anthracis
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' AMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciANTHRA:PURB-MONOMER.
BANT260799:GJAJ-319-MONOMER.
BANT261594:GJ7F-328-MONOMER.
UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Name:purBImported
Ordered Locus Names:BA_0290Imported, BAS0277Imported, GBAA_0290Imported
ORF Names:DH23_0274Imported, DJ42_4800Imported, DJ43_4836Imported, DJ44_4150Imported, DJ45_5597Imported, DJ48_3917Imported, DJ49_5204Imported, HYU01_01590Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_0290.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PFMX-ray2.00A/B1-435[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81ZH6.

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000033912.
KOiK01756.
OMAiERIIEDK.
OrthoDBiEOG686NDB.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81ZH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISRYTRPEM GAIWTEENKF KAWLEVEILA CEAWAELGDI PKEDVKKIRE
60 70 80 90 100
HASFDIDRIY EIEKETRHDV VAFTRAVSET PALGEERKWV HYGLTSTDVV
110 120 130 140 150
DTALSYILKQ ANEIILKDLE NFVSILANKA KEHKYTIMMG RTHGVHAEPT
160 170 180 190 200
TFGLKLGLWY EEMKRNVERF KQAANTVRVG KLSGAVGTYA NIDPFVEKYV
210 220 230 240 250
CENLGLEAAP ISTQTLQRDR HAHYMSTLAL IATSIEKMAV EIRGLQKSET
260 270 280 290 300
REVEEAFAKG QKGSSAMPHK RNPIGSENMT GLARVIRGYM MTAYENVPLW
310 320 330 340 350
HERDISHSSA ERVILPDATI ALNYMLNRFG NIVKNLTVYP ENMKRNMTRT
360 370 380 390 400
YGLIYSQRVM LTLIDKGMVR EEAYDIVQPK AMEAWETQVQ FKELVEADER
410 420 430
ITSKLTQEEI NECFNYEHHM QHVDTIFERL GLNEA
Length:435
Mass (Da):49,988
Last modified:June 1, 2003 - v1
Checksum:i772B8EB811E0CB98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24326.1.
AE017334 Genomic DNA. Translation: AAT29377.1.
AE017225 Genomic DNA. Translation: AAT52608.1.
CP008846 Genomic DNA. Translation: AIF54759.1.
CP007660 Genomic DNA. Translation: AIK06400.1.
CP007618 Genomic DNA. Translation: AIK33986.1.
CP008752 Genomic DNA. Translation: AIK51587.1.
CP007704 Genomic DNA. Translation: AIK59043.1.
JNOD01000011 Genomic DNA. Translation: KFJ82778.1.
JMPV01000005 Genomic DNA. Translation: KFL76796.1.
JMPU01000011 Genomic DNA. Translation: KFL79427.1.
RefSeqiNP_842840.1. NC_003997.3.
YP_016902.1. NC_007530.2.
YP_026557.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24326; AAP24326; BA_0290.
AAT29377; AAT29377; GBAA_0290.
AAT52608; AAT52608; BAS0277.
GeneIDi1085703.
2819273.
2850059.
KEGGiban:BA_0290.
bar:GBAA_0290.
bat:BAS0277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24326.1 .
AE017334 Genomic DNA. Translation: AAT29377.1 .
AE017225 Genomic DNA. Translation: AAT52608.1 .
CP008846 Genomic DNA. Translation: AIF54759.1 .
CP007660 Genomic DNA. Translation: AIK06400.1 .
CP007618 Genomic DNA. Translation: AIK33986.1 .
CP008752 Genomic DNA. Translation: AIK51587.1 .
CP007704 Genomic DNA. Translation: AIK59043.1 .
JNOD01000011 Genomic DNA. Translation: KFJ82778.1 .
JMPV01000005 Genomic DNA. Translation: KFL76796.1 .
JMPU01000011 Genomic DNA. Translation: KFL79427.1 .
RefSeqi NP_842840.1. NC_003997.3.
YP_016902.1. NC_007530.2.
YP_026557.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PFM X-ray 2.00 A/B 1-435 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_0290.

Protocols and materials databases

DNASUi 1085703.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP24326 ; AAP24326 ; BA_0290 .
AAT29377 ; AAT29377 ; GBAA_0290 .
AAT52608 ; AAT52608 ; BAS0277 .
GeneIDi 1085703.
2819273.
2850059.
KEGGi ban:BA_0290.
bar:GBAA_0290.
bat:BAS0277.

Phylogenomic databases

HOGENOMi HOG000033912.
KOi K01756.
OMAi ERIIEDK.
OrthoDBi EOG686NDB.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00132 .
UPA00075 ; UER00336 .
BioCyci ANTHRA:PURB-MONOMER.
BANT260799:GJAJ-319-MONOMER.
BANT261594:GJ7F-328-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81ZH6.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
InterProi IPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
Pfami PF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SMARTi SM00998. ADSL_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00928. purB. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate PortonImported.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SterneImported.
  3. "Crystal Structure of Adenylosuccinate Lyase (PurB) from Bacillus anthracis."
    Levdikov V.M., Blagova E.V., Wilkinson A.J., Wilson K.S.
    Submitted (APR-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestorImported and Ames AncestorImported.
  5. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  6. "Complete Genome Sequence of Bacillus anthracis HYU01, Isolated from Soil Samples in the Korean Peninsula."
    Kim S.K., Chung W.H., Kim S.H., Jung K.H., Kim N., Chai Y.G.
    Genome Announc. 2:e00769-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HYU01Imported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031021Imported, A.Br.003Imported, Smith 1013Imported and Zimbabwe 89Imported.
  8. "Draft Genome Sequence of Bacillus anthracis STI."
    Okinaka R.T., Challacombe J.F., Drees K., Birdsell D.N., Janke N., Naumann A., Seymour M., O'Neill H.H., Schupp J., Sahl J., Foster J.T., Pearson T., Keim P.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: STI-1Imported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BFVImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Delta SterneImported.

Entry informationi

Entry nameiQ81ZH6_BACAN
AccessioniPrimary (citable) accession number: Q81ZH6
Secondary accession number(s): E9RC82
, E9RC83, Q6I4C3, Q6KY25
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3