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Protein

Adenylosuccinate lyase

Gene

purB

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA), Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (COE56_27940), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (MCCC1A01412_21580), Adenylosuccinate lyase (COJ30_28330), Adenylosuccinate lyase (CN272_21985), Adenylosuccinate lyase (purB)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (COE56_27940), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (MCCC1A01412_21580), Adenylosuccinate lyase (COJ30_28330), Adenylosuccinate lyase (CN272_21985), Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132
UPA00075; UER00336

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Name:purBImported
Ordered Locus Names:GBAA_0290Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS0277

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PFMX-ray2.00A/B1-435[»]
SMRiQ81ZH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C83 Bacteria
COG0015 LUCA
HOGENOMiHOG000033912
KOiK01756
OMAiASSCEKI

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR019468 AdenyloSucc_lyase_C
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR004769 Pur_lyase
PfamiView protein in Pfam
PF10397 ADSL_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SMARTiView protein in SMART
SM00998 ADSL_C, 1 hit
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00928 purB, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q81ZH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRYTRPEM GAIWTEENKF KAWLEVEILA CEAWAELGDI PKEDVKKIRE
60 70 80 90 100
HASFDIDRIY EIEKETRHDV VAFTRAVSET PALGEERKWV HYGLTSTDVV
110 120 130 140 150
DTALSYILKQ ANEIILKDLE NFVSILANKA KEHKYTIMMG RTHGVHAEPT
160 170 180 190 200
TFGLKLGLWY EEMKRNVERF KQAANTVRVG KLSGAVGTYA NIDPFVEKYV
210 220 230 240 250
CENLGLEAAP ISTQTLQRDR HAHYMSTLAL IATSIEKMAV EIRGLQKSET
260 270 280 290 300
REVEEAFAKG QKGSSAMPHK RNPIGSENMT GLARVIRGYM MTAYENVPLW
310 320 330 340 350
HERDISHSSA ERVILPDATI ALNYMLNRFG NIVKNLTVYP ENMKRNMTRT
360 370 380 390 400
YGLIYSQRVM LTLIDKGMVR EEAYDIVQPK AMEAWETQVQ FKELVEADER
410 420 430
ITSKLTQEEI NECFNYEHHM QHVDTIFERL GLNEA
Length:435
Mass (Da):49,988
Last modified:June 1, 2003 - v1
Checksum:i772B8EB811E0CB98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA Translation: AAT29377.1
RefSeqiWP_000625683.1, NZ_PPES01000026.1

Genome annotation databases

EnsemblBacteriaiAAT29377; AAT29377; GBAA_0290
ANH84700; ANH84700; A8C77_01645
KLV16363; KLV16363; ABW01_20885
KEGGibar:GBAA_0290
PATRICifig|1392.230.peg.277

Similar proteinsi

Entry informationi

Entry nameiQ81ZH6_BACAN
AccessioniPrimary (citable) accession number: Q81ZH6
Secondary accession number(s): E9RC82
, E9RC83, Q6I4C3, Q6KY25
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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