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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (COE56_27940), Adenylosuccinate lyase (CN272_21985), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (MCCC1A01412_21580), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (COJ30_28330)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:BA_0291, GBAA_0291, BAS0278
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007981 – 239Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST239

Interactioni

Protein-protein interaction databases

IntActiQ81ZH5, 1 interactor
STRINGi260799.BAS0278

Structurei

3D structure databases

ProteinModelPortaliQ81ZH5
SMRiQ81ZH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8V Bacteria
COG0152 LUCA
HOGENOMiHOG000082629
KOiK01923
OMAiFNAQKRG

Family and domain databases

CDDicd01415 SAICAR_synt_PurC, 1 hit
HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR033934 SAICAR_synt_PurC
IPR001636 SAICAR_synth
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR00081 purC, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit
PS01058 SAICAR_SYNTHETASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q81ZH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLELLYEG KAKRIYRTES ADMVWVEYKD SATAFNGEKK ETITGKGRLN
60 70 80 90 100
NEITTLLFRK LQEVGIKTHF VEKLSETEQL VKKVSIIPLE VVTRNVIAGS
110 120 130 140 150
LSKRLGMEEG TVLAEPIVEF YFKDDDLGDP LVTEDHIRVL NVASPEQVSV
160 170 180 190 200
LRDMALQINQ VLIDHFASCR VRLVDFKLEF GVTDEGAIIL ADEISPDTCR
210 220 230
LWDETSNEKF DKDVFRRDLG NLTDAYEEIL KRLGGISHV
Length:239
Mass (Da):27,178
Last modified:June 1, 2003 - v1
Checksum:i427CB3AA4A9FFD14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP24327.1
AE017334 Genomic DNA Translation: AAT29378.1
AE017225 Genomic DNA Translation: AAT52609.1
RefSeqiNP_842841.1, NC_003997.3
WP_001170540.1, NZ_NRJB01000008.1
YP_026558.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP24327; AAP24327; BA_0291
AAT29378; AAT29378; GBAA_0291
AAT52609; AAT52609; BAS0278
GeneIDi1088229
2848479
KEGGiban:BA_0291
bar:GBAA_0291
bat:BAS0278
PATRICifig|198094.11.peg.282

Similar proteinsi

Entry informationi

Entry nameiPUR7_BACAN
AccessioniPrimary (citable) accession number: Q81ZH5
Secondary accession number(s): Q6I4C2, Q6KY24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health