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Q81ZH0

- PUR5_BACAN

UniProt

Q81ZH0 - PUR5_BACAN

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, BA_0296, GBAA_0296, BAS0283
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:PURM-MONOMER.
BANT260799:GJAJ-325-MONOMER.
BANT261594:GJ7F-334-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:BA_0296, GBAA_0296, BAS0283
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000148194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_0296.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni19 – 268
Helixi27 – 293
Beta strandi44 – 463
Beta strandi53 – 6311
Helixi68 – 747
Helixi80 – 9314
Turni94 – 963
Beta strandi98 – 11013
Helixi113 – 13018
Beta strandi133 – 1419
Beta strandi152 – 16211
Beta strandi177 – 1826
Beta strandi184 – 1863
Helixi191 – 1999
Beta strandi211 – 2133
Helixi217 – 2215
Helixi229 – 23810
Helixi251 – 2555
Helixi257 – 2593
Beta strandi264 – 2696
Helixi277 – 28610
Helixi290 – 2934
Turni294 – 2963
Beta strandi301 – 3077
Turni309 – 3113
Helixi312 – 32211
Beta strandi326 – 34116

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BTUX-ray2.31A/B1-346[»]
ProteinModelPortaliQ81ZH0.
SMRiQ81ZH0. Positions 13-341.

Miscellaneous databases

EvolutionaryTraceiQ81ZH0.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNIETEEM.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81ZH0-1 [UniParc]FASTAAdd to Basket

« Hide

MANAYKQAGV DIEAGYEAVS RMKKHVQTTM RKEVLGGLGG FGGMFDLSKF    50
ALEEPVLVSG TDGVGTKLML AFMADKHDTI GIDAVAMCVN DIVVQGAEPL 100
FFLDYIACGK AEPSKIENIV KGISEGCRQA GCALIGGETA EMPGMYSTEE 150
YDLAGFTVGI VDKKKIVTGE KIEAGHVLIG LASSGIHSNG YSLVRKVLLE 200
DGELSLDRIY GRLELPLGEE LLKPTKIYVK PILELLKNHE VYGMAHITGG 250
GFIENIPRML PEGIGAEIEL GSWKIQPIFS LLQEVGKLEE KEMFNIFNMG 300
IGMVVAVKEE DAKDIVRLLE EQGETARIIG RTVQGAGVTF NGGKAL 346
Length:346
Mass (Da):37,256
Last modified:June 1, 2003 - v1
Checksum:i6A4825D9FF515A43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP24332.1.
AE017334 Genomic DNA. Translation: AAT29383.1.
AE017225 Genomic DNA. Translation: AAT52614.1.
RefSeqiNP_842846.1. NC_003997.3.
YP_016908.1. NC_007530.2.
YP_026563.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24332; AAP24332; BA_0296.
AAT29383; AAT29383; GBAA_0296.
AAT52614; AAT52614; BAS0283.
GeneIDi1085673.
2816181.
2851164.
KEGGiban:BA_0296.
bar:GBAA_0296.
bat:BAS0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP24332.1 .
AE017334 Genomic DNA. Translation: AAT29383.1 .
AE017225 Genomic DNA. Translation: AAT52614.1 .
RefSeqi NP_842846.1. NC_003997.3.
YP_016908.1. NC_007530.2.
YP_026563.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BTU X-ray 2.31 A/B 1-346 [» ]
ProteinModelPortali Q81ZH0.
SMRi Q81ZH0. Positions 13-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_0296.

Protocols and materials databases

DNASUi 1085673.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP24332 ; AAP24332 ; BA_0296 .
AAT29383 ; AAT29383 ; GBAA_0296 .
AAT52614 ; AAT52614 ; BAS0283 .
GeneIDi 1085673.
2816181.
2851164.
KEGGi ban:BA_0296.
bar:GBAA_0296.
bat:BAS0283.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi NIETEEM.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci ANTHRA:PURM-MONOMER.
BANT260799:GJAJ-325-MONOMER.
BANT261594:GJ7F-334-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81ZH0.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiPUR5_BACAN
AccessioniPrimary (citable) accession number: Q81ZH0
Secondary accession number(s): Q6I4B7, Q6KY19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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