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Q81ZH0

- PUR5_BACAN

UniProt

Q81ZH0 - PUR5_BACAN

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:PURM-MONOMER.
BANT260799:GJAJ-325-MONOMER.
BANT261594:GJ7F-334-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:BA_0296, GBAA_0296, BAS0283
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_0296.

Structurei

Secondary structure

1
346
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni19 – 268Combined sources
Helixi27 – 293Combined sources
Beta strandi44 – 463Combined sources
Beta strandi53 – 6311Combined sources
Helixi68 – 747Combined sources
Helixi80 – 9314Combined sources
Turni94 – 963Combined sources
Beta strandi98 – 11013Combined sources
Helixi113 – 13018Combined sources
Beta strandi133 – 1419Combined sources
Beta strandi152 – 16211Combined sources
Beta strandi177 – 1826Combined sources
Beta strandi184 – 1863Combined sources
Helixi191 – 1999Combined sources
Beta strandi211 – 2133Combined sources
Helixi217 – 2215Combined sources
Helixi229 – 23810Combined sources
Helixi251 – 2555Combined sources
Helixi257 – 2593Combined sources
Beta strandi264 – 2696Combined sources
Helixi277 – 28610Combined sources
Helixi290 – 2934Combined sources
Turni294 – 2963Combined sources
Beta strandi301 – 3077Combined sources
Turni309 – 3113Combined sources
Helixi312 – 32211Combined sources
Beta strandi326 – 34116Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BTUX-ray2.31A/B1-346[»]
ProteinModelPortaliQ81ZH0.
SMRiQ81ZH0. Positions 13-341.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81ZH0.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNIETEEM.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81ZH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANAYKQAGV DIEAGYEAVS RMKKHVQTTM RKEVLGGLGG FGGMFDLSKF
60 70 80 90 100
ALEEPVLVSG TDGVGTKLML AFMADKHDTI GIDAVAMCVN DIVVQGAEPL
110 120 130 140 150
FFLDYIACGK AEPSKIENIV KGISEGCRQA GCALIGGETA EMPGMYSTEE
160 170 180 190 200
YDLAGFTVGI VDKKKIVTGE KIEAGHVLIG LASSGIHSNG YSLVRKVLLE
210 220 230 240 250
DGELSLDRIY GRLELPLGEE LLKPTKIYVK PILELLKNHE VYGMAHITGG
260 270 280 290 300
GFIENIPRML PEGIGAEIEL GSWKIQPIFS LLQEVGKLEE KEMFNIFNMG
310 320 330 340
IGMVVAVKEE DAKDIVRLLE EQGETARIIG RTVQGAGVTF NGGKAL
Length:346
Mass (Da):37,256
Last modified:June 1, 2003 - v1
Checksum:i6A4825D9FF515A43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24332.1.
AE017334 Genomic DNA. Translation: AAT29383.1.
AE017225 Genomic DNA. Translation: AAT52614.1.
RefSeqiNP_842846.1. NC_003997.3.
YP_016908.1. NC_007530.2.
YP_026563.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24332; AAP24332; BA_0296.
AAT29383; AAT29383; GBAA_0296.
AAT52614; AAT52614; BAS0283.
GeneIDi1085673.
2816181.
2851164.
KEGGiban:BA_0296.
bar:GBAA_0296.
bat:BAS0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24332.1 .
AE017334 Genomic DNA. Translation: AAT29383.1 .
AE017225 Genomic DNA. Translation: AAT52614.1 .
RefSeqi NP_842846.1. NC_003997.3.
YP_016908.1. NC_007530.2.
YP_026563.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BTU X-ray 2.31 A/B 1-346 [» ]
ProteinModelPortali Q81ZH0.
SMRi Q81ZH0. Positions 13-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_0296.

Protocols and materials databases

DNASUi 1085673.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP24332 ; AAP24332 ; BA_0296 .
AAT29383 ; AAT29383 ; GBAA_0296 .
AAT52614 ; AAT52614 ; BAS0283 .
GeneIDi 1085673.
2816181.
2851164.
KEGGi ban:BA_0296.
bar:GBAA_0296.
bat:BAS0283.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi NIETEEM.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci ANTHRA:PURM-MONOMER.
BANT260799:GJAJ-325-MONOMER.
BANT261594:GJ7F-334-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81ZH0.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiPUR5_BACAN
AccessioniPrimary (citable) accession number: Q81ZH0
Secondary accession number(s): Q6I4B7, Q6KY19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3