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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ), Phosphoribosylformylglycinamidine synthase subunit PurS (yexA), Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurS (purS), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ), Phosphoribosylformylglycinamidine synthase subunit PurL (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:PURM-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:BA_0296, GBAA_0296, BAS0283
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001481941 – 346Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST346

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_0296.

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni19 – 26Combined sources8
Helixi27 – 29Combined sources3
Beta strandi38 – 40Combined sources3
Beta strandi44 – 46Combined sources3
Beta strandi53 – 63Combined sources11
Helixi68 – 74Combined sources7
Helixi80 – 93Combined sources14
Turni94 – 96Combined sources3
Beta strandi98 – 110Combined sources13
Helixi113 – 130Combined sources18
Beta strandi133 – 141Combined sources9
Beta strandi152 – 162Combined sources11
Beta strandi177 – 182Combined sources6
Beta strandi184 – 186Combined sources3
Helixi191 – 199Combined sources9
Beta strandi211 – 213Combined sources3
Helixi217 – 221Combined sources5
Helixi229 – 238Combined sources10
Helixi251 – 255Combined sources5
Helixi257 – 259Combined sources3
Beta strandi264 – 269Combined sources6
Helixi277 – 286Combined sources10
Helixi290 – 293Combined sources4
Turni294 – 296Combined sources3
Beta strandi301 – 307Combined sources7
Turni309 – 311Combined sources3
Helixi312 – 322Combined sources11
Beta strandi326 – 341Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BTUX-ray2.31A/B1-346[»]
ProteinModelPortaliQ81ZH0.
SMRiQ81ZH0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81ZH0.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150. LUCA.
HOGENOMiHOG000229090.
KOiK01933.
OMAiLNRHDTV.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004733. PurM_cligase.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81ZH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANAYKQAGV DIEAGYEAVS RMKKHVQTTM RKEVLGGLGG FGGMFDLSKF
60 70 80 90 100
ALEEPVLVSG TDGVGTKLML AFMADKHDTI GIDAVAMCVN DIVVQGAEPL
110 120 130 140 150
FFLDYIACGK AEPSKIENIV KGISEGCRQA GCALIGGETA EMPGMYSTEE
160 170 180 190 200
YDLAGFTVGI VDKKKIVTGE KIEAGHVLIG LASSGIHSNG YSLVRKVLLE
210 220 230 240 250
DGELSLDRIY GRLELPLGEE LLKPTKIYVK PILELLKNHE VYGMAHITGG
260 270 280 290 300
GFIENIPRML PEGIGAEIEL GSWKIQPIFS LLQEVGKLEE KEMFNIFNMG
310 320 330 340
IGMVVAVKEE DAKDIVRLLE EQGETARIIG RTVQGAGVTF NGGKAL
Length:346
Mass (Da):37,256
Last modified:June 1, 2003 - v1
Checksum:i6A4825D9FF515A43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24332.1.
AE017334 Genomic DNA. Translation: AAT29383.1.
AE017225 Genomic DNA. Translation: AAT52614.1.
RefSeqiNP_842846.1. NC_003997.3.
WP_001262436.1. NZ_LHUO01000019.1.
YP_026563.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24332; AAP24332; BA_0296.
AAT29383; AAT29383; GBAA_0296.
AAT52614; AAT52614; BAS0283.
GeneIDi1085673.
2851164.
KEGGiban:BA_0296.
bar:GBAA_0296.
bat:BAS0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24332.1.
AE017334 Genomic DNA. Translation: AAT29383.1.
AE017225 Genomic DNA. Translation: AAT52614.1.
RefSeqiNP_842846.1. NC_003997.3.
WP_001262436.1. NZ_LHUO01000019.1.
YP_026563.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BTUX-ray2.31A/B1-346[»]
ProteinModelPortaliQ81ZH0.
SMRiQ81ZH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_0296.

Protocols and materials databases

DNASUi1085673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP24332; AAP24332; BA_0296.
AAT29383; AAT29383; GBAA_0296.
AAT52614; AAT52614; BAS0283.
GeneIDi1085673.
2851164.
KEGGiban:BA_0296.
bar:GBAA_0296.
bat:BAS0283.

Phylogenomic databases

eggNOGiCOG0150. LUCA.
HOGENOMiHOG000229090.
KOiK01933.
OMAiLNRHDTV.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.
BioCyciANTHRA:PURM-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81ZH0.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004733. PurM_cligase.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPUR5_BACAN
AccessioniPrimary (citable) accession number: Q81ZH0
Secondary accession number(s): Q6I4B7, Q6KY19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.