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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM), Hydroxyethylthiazole kinase (thiM)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45Substrate; via amide nitrogenUniRule annotation1
Binding sitei121ATPUniRule annotation1
Binding sitei167ATPUniRule annotation1
Binding sitei194Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • thiamine biosynthetic process Source: TIGR
  • thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionKinase, Transferase
Biological processThiamine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00139

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:BA_0376, GBAA_0376, BAS0362
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569241 – 268Hydroxyethylthiazole kinaseAdd BLAST268

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS0362

Structurei

3D structure databases

ProteinModelPortaliQ81Z96
SMRiQ81Z96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4U Bacteria
COG2145 LUCA
HOGENOMiHOG000114352
KOiK00878
OMAiKRPLVHN

Family and domain databases

CDDicd01170 THZ_kinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_00228 Thz_kinase, 1 hit
InterProiView protein in InterPro
IPR000417 Hyethyz_kinase
IPR029056 Ribokinase-like
PANTHERiPTHR44423 PTHR44423, 1 hit
PfamiView protein in Pfam
PF02110 HK, 1 hit
PIRSFiPIRSF000513 Thz_kinase, 1 hit
PRINTSiPR01099 HYETHTZKNASE
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00694 thiM, 1 hit

Sequencei

Sequence statusi: Complete.

Q81Z96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTKEISKVV DLVRESNPLV HNITNVVVTN FTANGLLALG ASPVMAYAKE
60 70 80 90 100
EVAEMASIAG ALVLNMGTLR PDEVEAMLLA GKSANRNDVP VLFDPVGAGA
110 120 130 140 150
TSYRTEVARH IPAEIELAII RGNAAEIANV INEKWEIKGV DAGAGNGNVV
160 170 180 190 200
SIAKQAADEL NTVAVITGKE DVVTDGERTI VIRNGHSILT KITGTGCLLT
210 220 230 240 250
SVIGAFVAVE KDYVKAAVAA LTFYGVAAEL AAAKTVEKGP GSFQIEFLNQ
260
LANTTSGDIE KYGKIEVI
Length:268
Mass (Da):28,059
Last modified:June 1, 2003 - v1
Checksum:iB53502FADB94651B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP24406.1
AE017334 Genomic DNA Translation: AAT29471.1
AE017225 Genomic DNA Translation: AAT52693.1
RefSeqiNP_842920.1, NC_003997.3
WP_001092689.1, NZ_PPES01000011.1
YP_026642.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP24406; AAP24406; BA_0376
AAT29471; AAT29471; GBAA_0376
AAT52693; AAT52693; BAS0362
GeneIDi1087357
2847890
KEGGiban:BA_0376
bar:GBAA_0376
bat:BAS0362
PATRICifig|198094.11.peg.371

Similar proteinsi

Entry informationi

Entry nameiTHIM_BACAN
AccessioniPrimary (citable) accession number: Q81Z96
Secondary accession number(s): Q6I438, Q6KXU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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