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Q81YY0

- GLSA1_BACAN

UniProt

Q81YY0 - GLSA1_BACAN

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Protein
Glutaminase 1
Gene
glsA1, glsA-1, BA_0499, GBAA_0499, BAS0471
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Substrate By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei162 – 1621Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei193 – 1931Substrate By similarity
Binding sitei245 – 2451Substrate By similarity
Binding sitei263 – 2631Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciANTHRA:GLSA-1-MONOMER.
BANT260799:GJAJ-514-MONOMER.
BANT261594:GJ7F-536-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 1 (EC:3.5.1.2)
Gene namesi
Name:glsA1
Synonyms:glsA-1
Ordered Locus Names:BA_0499, GBAA_0499, BAS0471
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Glutaminase 1UniRule annotation
PRO_0000110588Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_0499.

Structurei

3D structure databases

ProteinModelPortaliQ81YY0.
SMRiQ81YY0. Positions 5-309.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiMMDVSQI.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81YY0-1 [UniParc]FASTAAdd to Basket

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MQCIETNNLQ QLLEQVKPYT KKGKLATYIP ELGNANPDDL GIAIFHKETE    50
YIHAGNSQTL FTLQSISKVI TLALALLDRG EEYVFSKVGM EPTGDPFNSI 100
IKLETTSPSK PLNPMINAGA LAITSMLAGK DNEEKMERIL HFVREITDNP 150
TINYSSKVAN SELETAYLNR SLCYYMKQNG IIDCDIEELM DLYTRQCAVE 200
VNCIDLARIG LIFAMDGYDP YKKKQIIPKH ITKICKTFMV TCGMYNESGE 250
FAIRVGIPAK SGVAGGIFGC VKGEMGIGIF GPALDANGNS IAGFKILELL 300
SAQEGWSIF 309
Length:309
Mass (Da):34,048
Last modified:June 1, 2003 - v1
Checksum:i56FFE294D77F0B35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP24522.1.
AE017334 Genomic DNA. Translation: AAT29592.1.
AE017225 Genomic DNA. Translation: AAT52802.1.
RefSeqiNP_843036.1. NC_003997.3.
YP_017117.1. NC_007530.2.
YP_026751.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24522; AAP24522; BA_0499.
AAT29592; AAT29592; GBAA_0499.
AAT52802; AAT52802; BAS0471.
GeneIDi1086143.
2816157.
2848080.
KEGGiban:BA_0499.
bar:GBAA_0499.
bat:BAS0471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP24522.1 .
AE017334 Genomic DNA. Translation: AAT29592.1 .
AE017225 Genomic DNA. Translation: AAT52802.1 .
RefSeqi NP_843036.1. NC_003997.3.
YP_017117.1. NC_007530.2.
YP_026751.1. NC_005945.1.

3D structure databases

ProteinModelPortali Q81YY0.
SMRi Q81YY0. Positions 5-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_0499.

Protocols and materials databases

DNASUi 1086143.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP24522 ; AAP24522 ; BA_0499 .
AAT29592 ; AAT29592 ; GBAA_0499 .
AAT52802 ; AAT52802 ; BAS0471 .
GeneIDi 1086143.
2816157.
2848080.
KEGGi ban:BA_0499.
bar:GBAA_0499.
bat:BAS0471.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi MMDVSQI.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci ANTHRA:GLSA-1-MONOMER.
BANT260799:GJAJ-514-MONOMER.
BANT261594:GJ7F-536-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiGLSA1_BACAN
AccessioniPrimary (citable) accession number: Q81YY0
Secondary accession number(s): Q6I3S9, Q6KXJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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