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Protein

Processive diacylglycerol beta-glucosyltransferase

Gene

ugtP

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).UniRule annotation

Catalytic activityi

UDP-alpha-D-glucose + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-(beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol + UDP.
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-(beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol + UDP.
UDP-glucose + 1,2-diacyl-sn-glycerol = UDP + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol.UniRule annotation

Pathwayi: diglucosyl-diacylglycerol biosynthesis

This protein is involved in the pathway diglucosyl-diacylglycerol biosynthesis, which is part of Glycolipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway diglucosyl-diacylglycerol biosynthesis and in Glycolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCarbohydrate metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00894

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
Processive diacylglycerol beta-glucosyltransferaseUniRule annotation (EC:2.4.1.315)
Alternative name(s):
Beta-diglucosyldiacylglycerol synthaseUniRule annotation
Short name:
Beta-DGSUniRule annotation
Short name:
DGlcDAG synthaseUniRule annotation
Short name:
Glc2-DAG synthaseUniRule annotation
Beta-gentiobiosyldiacylglycerol synthaseUniRule annotation
Beta-monoglucosyldiacylglycerol synthaseUniRule annotation
Short name:
Beta-MGSUniRule annotation
Short name:
MGlcDAG synthaseUniRule annotation
Beta-triglucosyldiacylglycerol synthaseUniRule annotation
Short name:
TGlcDAG synthaseUniRule annotation
Diglucosyl diacylglycerol synthase (1,6-linking)
Glucosyl-beta-1,6-glucosyldiacylglycerol synthaseUniRule annotation
UDP glucosyltransferaseUniRule annotation
UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferaseUniRule annotation
Gene namesi
Name:ugtPUniRule annotation
Ordered Locus Names:BA_0511, GBAA_0511, BAS0483
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003084471 – 388Processive diacylglycerol beta-glucosyltransferaseAdd BLAST388

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS0483

Structurei

3D structure databases

ProteinModelPortaliQ81YW9
SMRiQ81YW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. UgtP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108QBV Bacteria
COG0707 LUCA
HOGENOMiHOG000221565
KOiK03429
OMAiEPAGHIV

Family and domain databases

HAMAPiMF_01280 Diacylglyc_glucosyltr, 1 hit
InterProiView protein in InterPro
IPR009695 Diacylglyc_glucosyltr_N
IPR007235 Glyco_trans_28_C
IPR023589 Pro_diacylglycrl_glcsylTrfase
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF06925 MGDG_synth, 1 hit

Sequencei

Sequence statusi: Complete.

Q81YW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNPKVLIL TAHYGNGHVQ VAKTLEQTFR QKGIKDVIVC DLFGESHPVI
60 70 80 90 100
TDITKYLYLK SYTIGKELYR LFYYGVEKIY DKKIASWYAN FGRKRLKLLL
110 120 130 140 150
QAEKPDIVIN TFPIIAVPEL KKQTGISIPV YNVLTDFCVH KIWIHREVDR
160 170 180 190 200
YFVATDHVKK VMVDIGVPAE QIVETGIPIR SSFELKINPD IIYNKYQLCK
210 220 230 240 250
NKKILLIVAG AHGVLGSVKE LCQSFMSVPD LQVVVVCGKN EALKQDLVGV
260 270 280 290 300
QETNPDALKV FGYVENIDEL FRVTSCMITK PGGITLSEAA ALQVPVILYK
310 320 330 340 350
PVPGQENENA MYFERKGAAV VIRDDSEVFA KTEALLQDDM KLLQMKEAMK
360 370 380
SIYRPEPADH IVDTILAENH VEPNHIPIKS PALAQSFT
Length:388
Mass (Da):43,761
Last modified:June 1, 2003 - v1
Checksum:i258505FF5A850662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP24533.1
AE017334 Genomic DNA Translation: AAT29605.1
AE017225 Genomic DNA Translation: AAT52814.1
RefSeqiNP_843047.1, NC_003997.3
WP_000594708.1, NZ_PPES01000062.1
YP_026763.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP24533; AAP24533; BA_0511
AAT29605; AAT29605; GBAA_0511
AAT52814; AAT52814; BAS0483
GeneIDi1087727
2850475
KEGGiban:BA_0511
bar:GBAA_0511
bat:BAS0483
PATRICifig|198094.11.peg.510

Similar proteinsi

Entry informationi

Entry nameiUGTP_BACAN
AccessioniPrimary (citable) accession number: Q81YW9
Secondary accession number(s): Q6I3R7, Q6KXI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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