Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q81YV0

- GSA1_BACAN

UniProt

Q81YV0 - GSA1_BACAN

Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1

Gene

hemL1

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBANT260799:GJAJ-542-MONOMER.
    BANT261594:GJ7F-567-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSA 1UniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase 1UniRule annotation
    Short name:
    GSA-AT 1UniRule annotation
    Gene namesi
    Name:hemL1UniRule annotation
    Ordered Locus Names:BA_0531, GBAA_0531, BAS0499
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Glutamate-1-semialdehyde 2,1-aminomutase 1PRO_0000243536Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei270 – 2701N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ81YV0. 4 interactions.
    STRINGi198094.BA_0531.

    Structurei

    Secondary structure

    1
    434
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1813
    Helixi20 – 223
    Helixi26 – 283
    Helixi31 – 333
    Beta strandi41 – 466
    Beta strandi48 – 514
    Beta strandi56 – 594
    Helixi62 – 643
    Helixi74 – 8613
    Helixi95 – 10713
    Beta strandi112 – 1198
    Helixi120 – 13516
    Beta strandi139 – 1435
    Helixi152 – 1554
    Beta strandi167 – 1704
    Helixi175 – 1784
    Beta strandi181 – 1844
    Helixi189 – 19911
    Helixi200 – 2023
    Beta strandi203 – 2086
    Beta strandi210 – 2123
    Helixi224 – 23310
    Turni234 – 2363
    Beta strandi238 – 2425
    Turni244 – 2496
    Beta strandi250 – 2534
    Helixi255 – 2595
    Beta strandi264 – 2696
    Helixi270 – 2734
    Beta strandi279 – 2835
    Helixi285 – 2884
    Turni292 – 2943
    Beta strandi295 – 2973
    Turni302 – 3054
    Helixi307 – 32014
    Helixi325 – 34622
    Beta strandi351 – 3566
    Beta strandi359 – 3679
    Helixi372 – 3776
    Helixi380 – 39213
    Helixi413 – 43220

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3L44X-ray2.05A/B1-434[»]
    ProteinModelPortaliQ81YV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ81YV0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiPVVMERA.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81YV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVKFTKSEA LHKEALEHIV GGVNSPSRSF KAVGGGAPIA MERGKGAYFW    50
    DVDGNKYIDY LAAYGPIITG HAHPHITKAI TTAAENGVLY GTPTALEVKF 100
    AKMLKEAMPA LDKVRFVNSG TEAVMTTIRV ARAYTGRTKI MKFAGCYHGH 150
    SDLVLVAAGS GPSTLGTPDS AGVPQSIAQE VITVPFNNVE TLKEALDKWG 200
    HEVAAILVEP IVGNFGIVEP KPGFLEKVNE LVHEAGALVI YDEVITAFRF 250
    MYGGAQDLLG VTPDLTALGK VIGGGLPIGA YGGKKEIMEQ VAPLGPAYQA 300
    GTMAGNPASM ASGIACLEVL QQEGLYEKLD ELGAMLEKGI LEQAAKHNID 350
    ITLNRLKGAL TVYFTTNTIE DYDAAQDTDG EMFGKFFKLM LQEGVNLAPS 400
    KYEAWFLTTE HTKEDIEYTI EAVGRAFAAL ADNK 434
    Length:434
    Mass (Da):46,432
    Last modified:June 1, 2003 - v1
    Checksum:i3C6A06070A078FEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP24552.1.
    AE017225 Genomic DNA. Translation: AAT52830.1.
    AE017334 Genomic DNA. Translation: AAT29625.1.
    RefSeqiNP_843066.1. NC_003997.3.
    YP_017150.1. NC_007530.2.
    YP_026779.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP24552; AAP24552; BA_0531.
    AAT29625; AAT29625; GBAA_0531.
    AAT52830; AAT52830; BAS0499.
    GeneIDi1087796.
    2820043.
    2852947.
    KEGGiban:BA_0531.
    bar:GBAA_0531.
    bat:BAS0499.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP24552.1 .
    AE017225 Genomic DNA. Translation: AAT52830.1 .
    AE017334 Genomic DNA. Translation: AAT29625.1 .
    RefSeqi NP_843066.1. NC_003997.3.
    YP_017150.1. NC_007530.2.
    YP_026779.1. NC_005945.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3L44 X-ray 2.05 A/B 1-434 [» ]
    ProteinModelPortali Q81YV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q81YV0. 4 interactions.
    STRINGi 198094.BA_0531.

    Protocols and materials databases

    DNASUi 1087796.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP24552 ; AAP24552 ; BA_0531 .
    AAT29625 ; AAT29625 ; GBAA_0531 .
    AAT52830 ; AAT52830 ; BAS0499 .
    GeneIDi 1087796.
    2820043.
    2852947.
    KEGGi ban:BA_0531.
    bar:GBAA_0531.
    bat:BAS0499.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi PVVMERA.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci BANT260799:GJAJ-542-MONOMER.
    BANT261594:GJ7F-567-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q81YV0.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.

    Entry informationi

    Entry nameiGSA1_BACAN
    AccessioniPrimary (citable) accession number: Q81YV0
    Secondary accession number(s): Q6I3Q1, Q6KXG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3