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Q81YV0

- GSA1_BACAN

UniProt

Q81YV0 - GSA1_BACAN

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase 1
Gene
hemL1, BA_0531, GBAA_0531, BAS0499
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-542-MONOMER.
BANT261594:GJ7F-567-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1 (EC:5.4.3.8)
Short name:
GSA 1
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name:
GSA-AT 1
Gene namesi
Name:hemL1
Ordered Locus Names:BA_0531, GBAA_0531, BAS0499
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotation
PRO_0000243536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ81YV0. 4 interactions.
STRINGi198094.BA_0531.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1813
Helixi20 – 223
Helixi26 – 283
Helixi31 – 333
Beta strandi41 – 466
Beta strandi48 – 514
Beta strandi56 – 594
Helixi62 – 643
Helixi74 – 8613
Helixi95 – 10713
Beta strandi112 – 1198
Helixi120 – 13516
Beta strandi139 – 1435
Helixi152 – 1554
Beta strandi167 – 1704
Helixi175 – 1784
Beta strandi181 – 1844
Helixi189 – 19911
Helixi200 – 2023
Beta strandi203 – 2086
Beta strandi210 – 2123
Helixi224 – 23310
Turni234 – 2363
Beta strandi238 – 2425
Turni244 – 2496
Beta strandi250 – 2534
Helixi255 – 2595
Beta strandi264 – 2696
Helixi270 – 2734
Beta strandi279 – 2835
Helixi285 – 2884
Turni292 – 2943
Beta strandi295 – 2973
Turni302 – 3054
Helixi307 – 32014
Helixi325 – 34622
Beta strandi351 – 3566
Beta strandi359 – 3679
Helixi372 – 3776
Helixi380 – 39213
Helixi413 – 43220

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3L44X-ray2.05A/B1-434[»]
ProteinModelPortaliQ81YV0.

Miscellaneous databases

EvolutionaryTraceiQ81YV0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiPVVMERA.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81YV0-1 [UniParc]FASTAAdd to Basket

« Hide

MVVKFTKSEA LHKEALEHIV GGVNSPSRSF KAVGGGAPIA MERGKGAYFW    50
DVDGNKYIDY LAAYGPIITG HAHPHITKAI TTAAENGVLY GTPTALEVKF 100
AKMLKEAMPA LDKVRFVNSG TEAVMTTIRV ARAYTGRTKI MKFAGCYHGH 150
SDLVLVAAGS GPSTLGTPDS AGVPQSIAQE VITVPFNNVE TLKEALDKWG 200
HEVAAILVEP IVGNFGIVEP KPGFLEKVNE LVHEAGALVI YDEVITAFRF 250
MYGGAQDLLG VTPDLTALGK VIGGGLPIGA YGGKKEIMEQ VAPLGPAYQA 300
GTMAGNPASM ASGIACLEVL QQEGLYEKLD ELGAMLEKGI LEQAAKHNID 350
ITLNRLKGAL TVYFTTNTIE DYDAAQDTDG EMFGKFFKLM LQEGVNLAPS 400
KYEAWFLTTE HTKEDIEYTI EAVGRAFAAL ADNK 434
Length:434
Mass (Da):46,432
Last modified:June 1, 2003 - v1
Checksum:i3C6A06070A078FEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP24552.1.
AE017225 Genomic DNA. Translation: AAT52830.1.
AE017334 Genomic DNA. Translation: AAT29625.1.
RefSeqiNP_843066.1. NC_003997.3.
YP_017150.1. NC_007530.2.
YP_026779.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24552; AAP24552; BA_0531.
AAT29625; AAT29625; GBAA_0531.
AAT52830; AAT52830; BAS0499.
GeneIDi1087796.
2820043.
2852947.
KEGGiban:BA_0531.
bar:GBAA_0531.
bat:BAS0499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP24552.1 .
AE017225 Genomic DNA. Translation: AAT52830.1 .
AE017334 Genomic DNA. Translation: AAT29625.1 .
RefSeqi NP_843066.1. NC_003997.3.
YP_017150.1. NC_007530.2.
YP_026779.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3L44 X-ray 2.05 A/B 1-434 [» ]
ProteinModelPortali Q81YV0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q81YV0. 4 interactions.
STRINGi 198094.BA_0531.

Protocols and materials databases

DNASUi 1087796.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP24552 ; AAP24552 ; BA_0531 .
AAT29625 ; AAT29625 ; GBAA_0531 .
AAT52830 ; AAT52830 ; BAS0499 .
GeneIDi 1087796.
2820043.
2852947.
KEGGi ban:BA_0531.
bar:GBAA_0531.
bat:BAS0499.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi PVVMERA.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci BANT260799:GJAJ-542-MONOMER.
BANT261594:GJ7F-567-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81YV0.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.

Entry informationi

Entry nameiGSA1_BACAN
AccessioniPrimary (citable) accession number: Q81YV0
Secondary accession number(s): Q6I3Q1, Q6KXG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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