Transketolase - Bacillus anthracis

Preferred order of sections

Names and origin

Protein names

Submitted name:
Transketolase EMBL AAP27491.1
EC=2.2.1.1 EMBL AAP27491.1

Gene names

Name:	tkt2 EMBL AAP27491.1
Ordered Locus Names:	BA_3744 EMBL AAP27491.1, BAS3470 EMBL AAT55776.1, GBAA_3744 EMBL AAT32858.1

Organism

Bacillus anthracis [Reference proteome] [HAMAP]

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	666 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Magnesium SAAS SAAS005474 PDB 3M49 Metal-binding SAAS SAAS005474 PDB 3M49 Thiamine pyrophosphate SAAS SAAS005474
Molecular function	Transferase SAAS SAAS005474 EMBL AAP27491.1
Technical term	3D-structure PDB 3M49 Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transketolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

157

1

Magnesium PDB 3M49

Metal binding

187

1

Magnesium PDB 3M49

Metal binding

189

1

Magnesium; via carbonyl oxygen PDB 3M49

Sequences

Sequence

Length

Mass (Da)

Tools

Q81Y15 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 12765521989F64A4
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FASTA

666

72,409

        10         20         30         40         50         60 
MSHSIEQLSI NTIRTLSIDA IEKANSGHPG MPMGAAPMAY TLWTQFMKHN PNNPTWFNRD 

        70         80         90        100        110        120 
RFVLSAGHGS MLLYSLLHLS GYDVTMDDLK NFRQWGSKTP GHPEYGHTAG VDATTGPLGQ 

       130        140        150        160        170        180 
GIATAVGMAM AERHLAAKYN RDAYNIVDHY TYAICGDGDL MEGVSAEASS LAAHLQLGRL 

       190        200        210        220        230        240 
VVLYDSNDIS LDGDLNRSFS ESVEDRYKAY GWQVIRVEDG NDIEAIAKAI EEAKADEKRP 

       250        260        270        280        290        300 
TLIEVRTTIG FGSPNKSGKS ASHGSPLGVE ETKLTKEAYA WTAEQDFHVA EEVYENFRKT 

       310        320        330        340        350        360 
VQDVGETAQA EWNTMLGEYA QAYPELANEL QAAMNGLLPE GWEQNLPTYE LGSKAATRNS 

       370        380        390        400        410        420 
SGAVINAIAE SVPSFFGGSA DLAGSNKTYM NNEKDFTRDD YSGKNIWYGV REFAMGAAMN 

       430        440        450        460        470        480 
GIALHGGLKT YGGTFFVFSD YLRPAIRLAA LMQLPVTYVF THDSIAVGED GPTHEPIEQL 

       490        500        510        520        530        540 
AALRAMPNVS VIRPADGNES VAAWRLALES TNKPTALVLT RQDLPTLEGA KDDTYEKVAK 

       550        560        570        580        590        600 
GAYVVSASKK ETADVILLAT GSEVSLAVEA QKALAVDGVD ASVVSMPSMD RFEAQTAEYK 

       610        620        630        640        650        660 
ESVLPKAVTK RFAIEMGATF GWHRYVGLEG DVLGIDTFGA SAPGEKIMEE YGFTVENVVR 


KVKEML

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. Fraser C.M. Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames EMBL AAP27491.1 and Ames / isolate Porton.
[2]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne EMBL AAT55776.1.
[3]	"The complete genome sequence of Bacillus anthracis Ames "Ancestor"." Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A. J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames Ancestor EMBL AAT32858.1 and Ames ancestor.
[4]	Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Ames EMBL AAP27491.1.
[5]	"Crystal Structure of Transketolase Complexed with Thiamine Diphosphate from Bacillus anthracis." Maltseva N., Kim Y., Kwon K., Anderson W.F., Joachimiak A. Submitted (MAR-2010) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016879 Genomic DNA. Translation: AAP27491.1.
AE017334 Genomic DNA. Translation: AAT32858.1.
AE017225 Genomic DNA. Translation: AAT55776.1.

RefSeq

NP_846005.1. NC_003997.3.
YP_020383.1. NC_007530.2.
YP_029725.1. NC_005945.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3M49	X-ray	2.00	A/B	1-666	[»]

SMR

Q81Y15. Positions 4-666.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q81Y15. 6 interactions.

STRING

198094.BA_3744.

Protocols and materials databases

DNASU

1087096.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAP27491; AAP27491; BA_3744.
AAT32858; AAT32858; GBAA_3744.
AAT55776; AAT55776; BAS3470.

GeneID

1087096.
2818869.
2850559.

KEGG

ban:BA_3744.
bar:GBAA_3744.
bat:BAS3470.

Phylogenomic databases

HOGENOM

HOG000225954.

KO

K00615.

OMA

THADFEV.

ProtClustDB

PRK05899.

Enzyme and pathway databases

BioCyc

BANT260799:GJAJ-3531-MONOMER.
BANT261594:GJ7F-3644-MONOMER.

Family and domain databases

Gene3D

3.40.50.920. 1 hit.

InterPro

IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR005478. Transketolase_bac-like.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]

Pfam

PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]

SMART

SM00861. Transket_pyr. 1 hit.
[Graphical view]

SUPFAM

SSF52922. Transketo_C_like. 1 hit.

TIGRFAMs

TIGR00232. tktlase_bact. 1 hit.

PROSITE

PS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q81Y15_BACAN

Accession

Primary (citable) accession number: Q81Y15
Secondary accession number(s): E9QV35

Q6KPI1

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)