Reviewed,
UniProtKB/Swiss-Prot Q81X76 (TPIS_BACAN)
Last modified
November 3, 2009.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Triosephosphate isomerase Short name=TIM EC=5.3.1.1 Alternative name(s): Triose-phosphate isomerase | ||||||
| Gene names |
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| Organism | Bacillus anthracis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1392 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 251 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147 |
| Pathway | Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147 |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the triosephosphate isomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Gluconeogenesis Glycolysis Pentose shunt |
| Cellular component | Cytoplasm |
| Molecular function | Isomerase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysisInferred from electronic annotation. Source: HAMAP pentose-phosphate shuntInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 251 | 251 | Triosephosphate isomerase HAMAP MF_00147 | PRO_0000090174 | |||||
Sites | |||||||||
| Active site | 95 | 1 | Electrophile By similarity | ||||||
| Active site | 167 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 9 | 1 | Substrate By similarity | ||||||
| Binding site | 11 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 213 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. Fraser C.M.Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton. |
| [2] | "Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor. |
| [3] | "Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne. |
Cross-references
Sequence databases | |
|---|---|
| AE016879 Genomic DNA. Translation: AAP29026.1. AE017334 Genomic DNA. Translation: AAT34500.2. AE017225 Genomic DNA. Translation: AAT57276.1. | |
| RefSeq | NP_847540.1. YP_022025.2. YP_031226.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2BTM based on UniProtKB P00943. |
| SMR | Q81X76. Positions 2-249. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1084904. 2818888. 2851859. |
| GenomeReviews | Gene locus BA_5366 in contig AE016879_GR. Gene locus BAS4987 in contig AE017225_GR. Gene locus GBAA_5366 in contig AE017334_GR. |
| KEGG | ban:BA5366. bar:GBAA5366. bat:BAS4987. |
| TIGR | BA_5366. GBAA_5366. |
Phylogenomic databases | |
| HOGENOM | Q81X76. |
| OMA | AYHRESA. |
Enzyme and pathway databases | |
| BioCyc | BANT260799:BAS4987-MON. BANT261594:GBAA5366-MON. |
| BRENDA | 5.3.1.1. 267517. |
Family and domain databases | |
| HAMAP | MF_00147. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR000652. Triosephosphate_isomerase. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR21139. Triophos_ismrse. 1 hit. |
| Pfam | PF00121. TIM. 1 hit. [Graphical view] |
| ProDom | PD001005. Triophos_ismrse. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00419. tim. 1 hit. |
| PROSITE | PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TPIS_BACAN | ||||||||
| Accession | Primary (citable) accession number: Q81X76 Secondary accession number(s): Q6HR12, Q6KKD1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


