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Q81X75

- PGK_BACAN

UniProt

Q81X75 - PGK_BACAN

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Binding sitei201 – 2011ATPUniRule annotation
    Binding sitei292 – 2921ATP; via carbonyl oxygenUniRule annotation
    Binding sitei323 – 3231ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi350 – 3534ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciANTHRA:GFG-4116-MONOMER.
    BANT260799:GJAJ-5062-MONOMER.
    BANT261594:GJ7F-5238-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:BA_5367, GBAA_5367, BAS4988
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Phosphoglycerate kinasePRO_0000145899Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei183 – 1831PhosphoserineUniRule annotation
    Modified residuei299 – 2991PhosphothreonineUniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ81X75. 2 interactions.
    STRINGi198094.BA_5367.

    Structurei

    Secondary structure

    1
    394
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 83
    Beta strandi15 – 195
    Helixi35 – 395
    Helixi41 – 499
    Beta strandi53 – 575
    Helixi69 – 713
    Helixi74 – 8411
    Beta strandi94 – 963
    Helixi97 – 1048
    Beta strandi111 – 1133
    Helixi117 – 1193
    Helixi121 – 1255
    Helixi128 – 1358
    Beta strandi139 – 1435
    Helixi146 – 1483
    Turni154 – 1574
    Helixi158 – 1614
    Beta strandi165 – 1673
    Helixi169 – 18315
    Beta strandi187 – 1937
    Helixi198 – 20811
    Turni209 – 2113
    Beta strandi213 – 2175
    Helixi222 – 2287
    Helixi240 – 2423
    Helixi243 – 25614
    Beta strandi259 – 2613
    Beta strandi264 – 2718
    Beta strandi278 – 2825
    Helixi283 – 2853
    Beta strandi291 – 2955
    Helixi297 – 30812
    Beta strandi311 – 3177
    Helixi325 – 3273
    Helixi329 – 34012
    Beta strandi345 – 3484
    Helixi351 – 3599
    Helixi363 – 3653
    Beta strandi367 – 3693
    Helixi374 – 3807
    Helixi386 – 3894

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UWDX-ray1.68A1-394[»]
    ProteinModelPortaliQ81X75.
    SMRiQ81X75. Positions 1-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingUniRule annotation
    Regioni59 – 624Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227108.
    KOiK00927.
    OMAiWEALDIG.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81X75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKKSIRDVD LKGKRVFCRV DFNVPMKEGK ITDETRIRAA LPTIQYLVEQ    50
    GAKVILASHL GRPKGQAVEE LRLTPVAARL GELLGKDVKK ADEAFGPVAQ 100
    EMVAAMNEGD VLVLENVRFY AGEEKNDAEL AKEFAALADI FVNDAFGAAH 150
    RAHASTAGIA DYLPAVSGLL MEKELEVLGK ALSNPERPFT AIIGGAKVKD 200
    KIGLIRHLLD KVDNLIIGGG LAYTFVKALG HEIGLSLCED DKIELAKEFM 250
    QLAKEKGVNF YMPVDVVITE EFSETATTKI VGIDSIPSNW EGVDIGPKTR 300
    EIYADVIKNS KLVVWNGPMG VFEMTPFAEG TKAVGQALAD AEGTYSVIGG 350
    GDSAAAVEKF GMADKMSHIS TGGGASLEFM EGKELPGVVC LNDK 394
    Length:394
    Mass (Da):42,298
    Last modified:June 1, 2003 - v1
    Checksum:i0C383DEAA759658A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP29027.1.
    AE017334 Genomic DNA. Translation: AAT34502.1.
    AE017225 Genomic DNA. Translation: AAT57277.1.
    RefSeqiNP_847541.1. NC_003997.3.
    YP_022027.1. NC_007530.2.
    YP_031227.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP29027; AAP29027; BA_5367.
    AAT34502; AAT34502; GBAA_5367.
    AAT57277; AAT57277; BAS4988.
    GeneIDi1084905.
    2818481.
    2852195.
    KEGGiban:BA_5367.
    bar:GBAA_5367.
    bat:BAS4988.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP29027.1 .
    AE017334 Genomic DNA. Translation: AAT34502.1 .
    AE017225 Genomic DNA. Translation: AAT57277.1 .
    RefSeqi NP_847541.1. NC_003997.3.
    YP_022027.1. NC_007530.2.
    YP_031227.1. NC_005945.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UWD X-ray 1.68 A 1-394 [» ]
    ProteinModelPortali Q81X75.
    SMRi Q81X75. Positions 1-394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q81X75. 2 interactions.
    STRINGi 198094.BA_5367.

    Protocols and materials databases

    DNASUi 1084905.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP29027 ; AAP29027 ; BA_5367 .
    AAT34502 ; AAT34502 ; GBAA_5367 .
    AAT57277 ; AAT57277 ; BAS4988 .
    GeneIDi 1084905.
    2818481.
    2852195.
    KEGGi ban:BA_5367.
    bar:GBAA_5367.
    bat:BAS4988.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227108.
    KOi K00927.
    OMAi WEALDIG.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci ANTHRA:GFG-4116-MONOMER.
    BANT260799:GJAJ-5062-MONOMER.
    BANT261594:GJ7F-5238-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiPGK_BACAN
    AccessioniPrimary (citable) accession number: Q81X75
    Secondary accession number(s): Q6HR11, Q6KKD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3