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Q81X75

- PGK_BACAN

UniProt

Q81X75 - PGK_BACAN

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Protein

Phosphoglycerate kinase

Gene
pgk, BA_5367, GBAA_5367, BAS4988
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate By similarity
Binding sitei118 – 1181Substrate By similarity
Binding sitei151 – 1511Substrate By similarity
Binding sitei201 – 2011ATP By similarity
Binding sitei292 – 2921ATP; via carbonyl oxygen By similarity
Binding sitei323 – 3231ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi350 – 3534ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:GFG-4116-MONOMER.
BANT260799:GJAJ-5062-MONOMER.
BANT261594:GJ7F-5238-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:BA_5367, GBAA_5367, BAS4988
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Phosphoglycerate kinaseUniRule annotationPRO_0000145899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphoserine By similarity
Modified residuei299 – 2991Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ81X75. 2 interactions.
STRINGi198094.BA_5367.

Structurei

Secondary structure

1
394
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83
Beta strandi15 – 195
Helixi35 – 395
Helixi41 – 499
Beta strandi53 – 575
Helixi69 – 713
Helixi74 – 8411
Beta strandi94 – 963
Helixi97 – 1048
Beta strandi111 – 1133
Helixi117 – 1193
Helixi121 – 1255
Helixi128 – 1358
Beta strandi139 – 1435
Helixi146 – 1483
Turni154 – 1574
Helixi158 – 1614
Beta strandi165 – 1673
Helixi169 – 18315
Beta strandi187 – 1937
Helixi198 – 20811
Turni209 – 2113
Beta strandi213 – 2175
Helixi222 – 2287
Helixi240 – 2423
Helixi243 – 25614
Beta strandi259 – 2613
Beta strandi264 – 2718
Beta strandi278 – 2825
Helixi283 – 2853
Beta strandi291 – 2955
Helixi297 – 30812
Beta strandi311 – 3177
Helixi325 – 3273
Helixi329 – 34012
Beta strandi345 – 3484
Helixi351 – 3599
Helixi363 – 3653
Beta strandi367 – 3693
Helixi374 – 3807
Helixi386 – 3894

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UWDX-ray1.68A1-394[»]
ProteinModelPortaliQ81X75.
SMRiQ81X75. Positions 1-394.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate binding By similarity
Regioni59 – 624Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiWEALDIG.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81X75-1 [UniParc]FASTAAdd to Basket

« Hide

MNKKSIRDVD LKGKRVFCRV DFNVPMKEGK ITDETRIRAA LPTIQYLVEQ    50
GAKVILASHL GRPKGQAVEE LRLTPVAARL GELLGKDVKK ADEAFGPVAQ 100
EMVAAMNEGD VLVLENVRFY AGEEKNDAEL AKEFAALADI FVNDAFGAAH 150
RAHASTAGIA DYLPAVSGLL MEKELEVLGK ALSNPERPFT AIIGGAKVKD 200
KIGLIRHLLD KVDNLIIGGG LAYTFVKALG HEIGLSLCED DKIELAKEFM 250
QLAKEKGVNF YMPVDVVITE EFSETATTKI VGIDSIPSNW EGVDIGPKTR 300
EIYADVIKNS KLVVWNGPMG VFEMTPFAEG TKAVGQALAD AEGTYSVIGG 350
GDSAAAVEKF GMADKMSHIS TGGGASLEFM EGKELPGVVC LNDK 394
Length:394
Mass (Da):42,298
Last modified:June 1, 2003 - v1
Checksum:i0C383DEAA759658A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP29027.1.
AE017334 Genomic DNA. Translation: AAT34502.1.
AE017225 Genomic DNA. Translation: AAT57277.1.
RefSeqiNP_847541.1. NC_003997.3.
YP_022027.1. NC_007530.2.
YP_031227.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29027; AAP29027; BA_5367.
AAT34502; AAT34502; GBAA_5367.
AAT57277; AAT57277; BAS4988.
GeneIDi1084905.
2818481.
2852195.
KEGGiban:BA_5367.
bar:GBAA_5367.
bat:BAS4988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP29027.1 .
AE017334 Genomic DNA. Translation: AAT34502.1 .
AE017225 Genomic DNA. Translation: AAT57277.1 .
RefSeqi NP_847541.1. NC_003997.3.
YP_022027.1. NC_007530.2.
YP_031227.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UWD X-ray 1.68 A 1-394 [» ]
ProteinModelPortali Q81X75.
SMRi Q81X75. Positions 1-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q81X75. 2 interactions.
STRINGi 198094.BA_5367.

Protocols and materials databases

DNASUi 1084905.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP29027 ; AAP29027 ; BA_5367 .
AAT34502 ; AAT34502 ; GBAA_5367 .
AAT57277 ; AAT57277 ; BAS4988 .
GeneIDi 1084905.
2818481.
2852195.
KEGGi ban:BA_5367.
bar:GBAA_5367.
bat:BAS4988.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi WEALDIG.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci ANTHRA:GFG-4116-MONOMER.
BANT260799:GJAJ-5062-MONOMER.
BANT261594:GJ7F-5238-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiPGK_BACAN
AccessioniPrimary (citable) accession number: Q81X75
Secondary accession number(s): Q6HR11, Q6KKD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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