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Q81X75

- PGK_BACAN

UniProt

Q81X75 - PGK_BACAN

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Binding sitei151 – 1511SubstrateUniRule annotation
Binding sitei201 – 2011ATPUniRule annotation
Binding sitei292 – 2921ATP; via carbonyl oxygenUniRule annotation
Binding sitei323 – 3231ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi350 – 3534ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:GFG-4116-MONOMER.
BANT260799:GJAJ-5062-MONOMER.
BANT261594:GJ7F-5238-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:BA_5367, GBAA_5367, BAS4988
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Phosphoglycerate kinasePRO_0000145899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831PhosphoserineUniRule annotation
Modified residuei299 – 2991PhosphothreonineUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

IntActiQ81X75. 2 interactions.
STRINGi198094.BA_5367.

Structurei

Secondary structure

1
394
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83Combined sources
Beta strandi15 – 195Combined sources
Helixi35 – 395Combined sources
Helixi41 – 499Combined sources
Beta strandi53 – 575Combined sources
Helixi69 – 713Combined sources
Helixi74 – 8411Combined sources
Beta strandi94 – 963Combined sources
Helixi97 – 1048Combined sources
Beta strandi111 – 1133Combined sources
Helixi117 – 1193Combined sources
Helixi121 – 1255Combined sources
Helixi128 – 1358Combined sources
Beta strandi139 – 1435Combined sources
Helixi146 – 1483Combined sources
Turni154 – 1574Combined sources
Helixi158 – 1614Combined sources
Beta strandi165 – 1673Combined sources
Helixi169 – 18315Combined sources
Beta strandi187 – 1937Combined sources
Helixi198 – 20811Combined sources
Turni209 – 2113Combined sources
Beta strandi213 – 2175Combined sources
Helixi222 – 2287Combined sources
Helixi240 – 2423Combined sources
Helixi243 – 25614Combined sources
Beta strandi259 – 2613Combined sources
Beta strandi264 – 2718Combined sources
Beta strandi278 – 2825Combined sources
Helixi283 – 2853Combined sources
Beta strandi291 – 2955Combined sources
Helixi297 – 30812Combined sources
Beta strandi311 – 3177Combined sources
Helixi325 – 3273Combined sources
Helixi329 – 34012Combined sources
Beta strandi345 – 3484Combined sources
Helixi351 – 3599Combined sources
Helixi363 – 3653Combined sources
Beta strandi367 – 3693Combined sources
Helixi374 – 3807Combined sources
Helixi386 – 3894Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UWDX-ray1.68A1-394[»]
ProteinModelPortaliQ81X75.
SMRiQ81X75. Positions 1-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingUniRule annotation
Regioni59 – 624Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiWEALDIG.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81X75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKKSIRDVD LKGKRVFCRV DFNVPMKEGK ITDETRIRAA LPTIQYLVEQ
60 70 80 90 100
GAKVILASHL GRPKGQAVEE LRLTPVAARL GELLGKDVKK ADEAFGPVAQ
110 120 130 140 150
EMVAAMNEGD VLVLENVRFY AGEEKNDAEL AKEFAALADI FVNDAFGAAH
160 170 180 190 200
RAHASTAGIA DYLPAVSGLL MEKELEVLGK ALSNPERPFT AIIGGAKVKD
210 220 230 240 250
KIGLIRHLLD KVDNLIIGGG LAYTFVKALG HEIGLSLCED DKIELAKEFM
260 270 280 290 300
QLAKEKGVNF YMPVDVVITE EFSETATTKI VGIDSIPSNW EGVDIGPKTR
310 320 330 340 350
EIYADVIKNS KLVVWNGPMG VFEMTPFAEG TKAVGQALAD AEGTYSVIGG
360 370 380 390
GDSAAAVEKF GMADKMSHIS TGGGASLEFM EGKELPGVVC LNDK
Length:394
Mass (Da):42,298
Last modified:June 1, 2003 - v1
Checksum:i0C383DEAA759658A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29027.1.
AE017334 Genomic DNA. Translation: AAT34502.1.
AE017225 Genomic DNA. Translation: AAT57277.1.
RefSeqiNP_847541.1. NC_003997.3.
WP_001036337.1. NZ_JHDR01000056.1.
YP_022027.1. NC_007530.2.
YP_031227.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29027; AAP29027; BA_5367.
AAT34502; AAT34502; GBAA_5367.
AAT57277; AAT57277; BAS4988.
GeneIDi1084905.
2818481.
2852195.
KEGGiban:BA_5367.
bar:GBAA_5367.
bat:BAS4988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29027.1 .
AE017334 Genomic DNA. Translation: AAT34502.1 .
AE017225 Genomic DNA. Translation: AAT57277.1 .
RefSeqi NP_847541.1. NC_003997.3.
WP_001036337.1. NZ_JHDR01000056.1.
YP_022027.1. NC_007530.2.
YP_031227.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UWD X-ray 1.68 A 1-394 [» ]
ProteinModelPortali Q81X75.
SMRi Q81X75. Positions 1-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q81X75. 2 interactions.
STRINGi 198094.BA_5367.

Protocols and materials databases

DNASUi 1084905.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP29027 ; AAP29027 ; BA_5367 .
AAT34502 ; AAT34502 ; GBAA_5367 .
AAT57277 ; AAT57277 ; BAS4988 .
GeneIDi 1084905.
2818481.
2852195.
KEGGi ban:BA_5367.
bar:GBAA_5367.
bat:BAS4988.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi WEALDIG.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci ANTHRA:GFG-4116-MONOMER.
BANT260799:GJAJ-5062-MONOMER.
BANT261594:GJ7F-5238-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiPGK_BACAN
AccessioniPrimary (citable) accession number: Q81X75
Secondary accession number(s): Q6HR11, Q6KKD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3