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Protein

Peptidase T

Gene

pepT

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Zinc 1UniRule annotation
Active sitei81 – 811UniRule annotation
Metal bindingi142 – 1421Zinc 1UniRule annotation
Metal bindingi142 – 1421Zinc 2UniRule annotation
Active sitei176 – 1761Proton acceptorUniRule annotation
Metal bindingi177 – 1771Zinc 2UniRule annotation
Metal bindingi199 – 1991Zinc 1UniRule annotation
Metal bindingi381 – 3811Zinc 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • peptide catabolic process Source: UniProtKB-HAMAP
  • proteolysis Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciANTHRA:PEPT-1-MONOMER.
BANT260799:GJAJ-3647-MONOMER.
BANT261594:GJ7F-3763-MONOMER.

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Synonyms:pepT-1
Ordered Locus Names:BA_3872, GBAA_3872, BAS3588
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Peptidase TPRO_0000185277Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ81WU4. 5 interactions.
STRINGi198094.BA_3872.

Structurei

Secondary structure

410
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 1313Combined sources
Beta strandi25 – 295Combined sources
Helixi30 – 4617Combined sources
Beta strandi49 – 535Combined sources
Beta strandi59 – 635Combined sources
Beta strandi66 – 694Combined sources
Beta strandi74 – 796Combined sources
Beta strandi94 – 963Combined sources
Beta strandi104 – 1074Combined sources
Turni108 – 1114Combined sources
Beta strandi112 – 1143Combined sources
Turni116 – 1183Combined sources
Helixi122 – 1254Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi135 – 1373Combined sources
Helixi141 – 15818Combined sources
Beta strandi168 – 1747Combined sources
Turni176 – 1794Combined sources
Helixi182 – 1843Combined sources
Helixi187 – 1904Combined sources
Beta strandi193 – 1975Combined sources
Beta strandi205 – 2073Combined sources
Beta strandi212 – 22110Combined sources
Helixi227 – 2293Combined sources
Turni231 – 2333Combined sources
Helixi237 – 24610Combined sources
Helixi254 – 2563Combined sources
Beta strandi263 – 2719Combined sources
Beta strandi273 – 28614Combined sources
Helixi287 – 30822Combined sources
Helixi310 – 3123Combined sources
Beta strandi313 – 3219Combined sources
Helixi325 – 3284Combined sources
Helixi329 – 3324Combined sources
Helixi333 – 34412Combined sources
Beta strandi354 – 3563Combined sources
Helixi359 – 3657Combined sources
Beta strandi376 – 3794Combined sources
Beta strandi386 – 3883Combined sources
Helixi389 – 40921Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IFEX-ray1.55A1-410[»]
ProteinModelPortaliQ81WU4.
SMRiQ81WU4. Positions 3-408.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81WU4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2195. LUCA.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVYATIP.

Family and domain databases

CDDicd03892. M20_peptT. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81WU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEELIERFT RYVKIDTQSN EDSHTVPTTP GQIEFGKLLV EELKEVGLTE
60 70 80 90 100
VTMDDNGYVM ATLPANTDKD VPVIGFLAHL DTATDFTGKN VKPQIHENFD
110 120 130 140 150
GNAITLNEEL NIVLTPEQFP ELPSYKGHTI ITTDGTTLLG ADDKAGLTEI
160 170 180 190 200
MVAMNYLIHN PQIKHGKIRV AFTPDEEIGR GPAHFDVEAF GASFAYMMDG
210 220 230 240 250
GPLGGLEYES FNAAGAKLTF NGTNTHPGTA KNKMRNATKL AMEFNGHLPV
260 270 280 290 300
EEAPEYTEGY EGFYHLLSLN GDVEQSKAYY IIRDFDRKNF EARKNTIENI
310 320 330 340 350
VKQMQEKYGQ DAVVLEMNDQ YYNMLEKIEP VREIVDIAYE AMKSLNIEPN
360 370 380 390 400
IHPIRGGTDG SQLSYMGLPT PNIFTGGENY HGKFEYVSVD VMEKAVQVII
410
EIARRFEEQA
Length:410
Mass (Da):45,911
Last modified:June 1, 2003 - v1
Checksum:i6A57C9A46824FF7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27607.1.
AE017334 Genomic DNA. Translation: AAT32987.1.
AE017225 Genomic DNA. Translation: AAT55892.1.
RefSeqiNP_846121.1. NC_003997.3.
WP_000656974.1. NZ_LHUN01000026.1.
YP_029841.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27607; AAP27607; BA_3872.
AAT32987; AAT32987; GBAA_3872.
AAT55892; AAT55892; BAS3588.
GeneIDi1088747.
2849946.
KEGGiban:BA_3872.
bar:GBAA_3872.
bat:BAS3588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27607.1.
AE017334 Genomic DNA. Translation: AAT32987.1.
AE017225 Genomic DNA. Translation: AAT55892.1.
RefSeqiNP_846121.1. NC_003997.3.
WP_000656974.1. NZ_LHUN01000026.1.
YP_029841.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IFEX-ray1.55A1-410[»]
ProteinModelPortaliQ81WU4.
SMRiQ81WU4. Positions 3-408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81WU4. 5 interactions.
STRINGi198094.BA_3872.

Protein family/group databases

MEROPSiM20.003.

Protocols and materials databases

DNASUi1088747.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27607; AAP27607; BA_3872.
AAT32987; AAT32987; GBAA_3872.
AAT55892; AAT55892; BAS3588.
GeneIDi1088747.
2849946.
KEGGiban:BA_3872.
bar:GBAA_3872.
bat:BAS3588.

Phylogenomic databases

eggNOGiCOG2195. LUCA.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVYATIP.

Enzyme and pathway databases

BioCyciANTHRA:PEPT-1-MONOMER.
BANT260799:GJAJ-3647-MONOMER.
BANT261594:GJ7F-3763-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81WU4.

Family and domain databases

CDDicd03892. M20_peptT. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPT_BACAN
AccessioniPrimary (citable) accession number: Q81WU4
Secondary accession number(s): Q6HUZ7, Q6KP72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.