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Protein

Peptidase T

Gene

pepT

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Zinc 1UniRule annotation1
Active sitei81UniRule annotation1
Metal bindingi142Zinc 1UniRule annotation1
Metal bindingi142Zinc 2UniRule annotation1
Active sitei176Proton acceptorUniRule annotation1
Metal bindingi177Zinc 2UniRule annotation1
Metal bindingi199Zinc 1UniRule annotation1
Metal bindingi381Zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • peptide catabolic process Source: UniProtKB-HAMAP
  • proteolysis Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciANTHRA:PEPT-1-MONOMER.

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Synonyms:pepT-1
Ordered Locus Names:BA_3872, GBAA_3872, BAS3588
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852771 – 410Peptidase TAdd BLAST410

Interactioni

Protein-protein interaction databases

IntActiQ81WU4. 5 interactors.
STRINGi198094.BA_3872.

Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 13Combined sources13
Beta strandi25 – 29Combined sources5
Helixi30 – 46Combined sources17
Beta strandi49 – 53Combined sources5
Beta strandi59 – 63Combined sources5
Beta strandi66 – 69Combined sources4
Beta strandi74 – 79Combined sources6
Beta strandi94 – 96Combined sources3
Beta strandi104 – 107Combined sources4
Turni108 – 111Combined sources4
Beta strandi112 – 114Combined sources3
Turni116 – 118Combined sources3
Helixi122 – 125Combined sources4
Beta strandi130 – 132Combined sources3
Beta strandi135 – 137Combined sources3
Helixi141 – 158Combined sources18
Beta strandi168 – 174Combined sources7
Turni176 – 179Combined sources4
Helixi182 – 184Combined sources3
Helixi187 – 190Combined sources4
Beta strandi193 – 197Combined sources5
Beta strandi205 – 207Combined sources3
Beta strandi212 – 221Combined sources10
Helixi227 – 229Combined sources3
Turni231 – 233Combined sources3
Helixi237 – 246Combined sources10
Helixi254 – 256Combined sources3
Beta strandi263 – 271Combined sources9
Beta strandi273 – 286Combined sources14
Helixi287 – 308Combined sources22
Helixi310 – 312Combined sources3
Beta strandi313 – 321Combined sources9
Helixi325 – 328Combined sources4
Helixi329 – 332Combined sources4
Helixi333 – 344Combined sources12
Beta strandi354 – 356Combined sources3
Helixi359 – 365Combined sources7
Beta strandi376 – 379Combined sources4
Beta strandi386 – 388Combined sources3
Helixi389 – 409Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IFEX-ray1.55A1-410[»]
ProteinModelPortaliQ81WU4.
SMRiQ81WU4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81WU4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2195. LUCA.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVYATIP.

Family and domain databases

CDDicd03892. M20_peptT. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81WU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEELIERFT RYVKIDTQSN EDSHTVPTTP GQIEFGKLLV EELKEVGLTE
60 70 80 90 100
VTMDDNGYVM ATLPANTDKD VPVIGFLAHL DTATDFTGKN VKPQIHENFD
110 120 130 140 150
GNAITLNEEL NIVLTPEQFP ELPSYKGHTI ITTDGTTLLG ADDKAGLTEI
160 170 180 190 200
MVAMNYLIHN PQIKHGKIRV AFTPDEEIGR GPAHFDVEAF GASFAYMMDG
210 220 230 240 250
GPLGGLEYES FNAAGAKLTF NGTNTHPGTA KNKMRNATKL AMEFNGHLPV
260 270 280 290 300
EEAPEYTEGY EGFYHLLSLN GDVEQSKAYY IIRDFDRKNF EARKNTIENI
310 320 330 340 350
VKQMQEKYGQ DAVVLEMNDQ YYNMLEKIEP VREIVDIAYE AMKSLNIEPN
360 370 380 390 400
IHPIRGGTDG SQLSYMGLPT PNIFTGGENY HGKFEYVSVD VMEKAVQVII
410
EIARRFEEQA
Length:410
Mass (Da):45,911
Last modified:June 1, 2003 - v1
Checksum:i6A57C9A46824FF7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27607.1.
AE017334 Genomic DNA. Translation: AAT32987.1.
AE017225 Genomic DNA. Translation: AAT55892.1.
RefSeqiNP_846121.1. NC_003997.3.
WP_000656974.1. NZ_LHUN01000026.1.
YP_029841.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27607; AAP27607; BA_3872.
AAT32987; AAT32987; GBAA_3872.
AAT55892; AAT55892; BAS3588.
GeneIDi1088747.
2849946.
KEGGiban:BA_3872.
bar:GBAA_3872.
bat:BAS3588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27607.1.
AE017334 Genomic DNA. Translation: AAT32987.1.
AE017225 Genomic DNA. Translation: AAT55892.1.
RefSeqiNP_846121.1. NC_003997.3.
WP_000656974.1. NZ_LHUN01000026.1.
YP_029841.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IFEX-ray1.55A1-410[»]
ProteinModelPortaliQ81WU4.
SMRiQ81WU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81WU4. 5 interactors.
STRINGi198094.BA_3872.

Protein family/group databases

MEROPSiM20.003.

Protocols and materials databases

DNASUi1088747.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27607; AAP27607; BA_3872.
AAT32987; AAT32987; GBAA_3872.
AAT55892; AAT55892; BAS3588.
GeneIDi1088747.
2849946.
KEGGiban:BA_3872.
bar:GBAA_3872.
bat:BAS3588.

Phylogenomic databases

eggNOGiCOG2195. LUCA.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVYATIP.

Enzyme and pathway databases

BioCyciANTHRA:PEPT-1-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81WU4.

Family and domain databases

CDDicd03892. M20_peptT. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPT_BACAN
AccessioniPrimary (citable) accession number: Q81WU4
Secondary accession number(s): Q6HUZ7, Q6KP72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.