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Protein

Tyrosine recombinase XerC

Gene

xerC

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity).SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481UniRule annotation
Active sitei172 – 1721UniRule annotation
Active sitei245 – 2451UniRule annotation
Active sitei248 – 2481UniRule annotation
Active sitei271 – 2711UniRule annotation
Active sitei280 – 2801O-(3'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Chromosome partitionUniRule annotationSAAS annotation, DNA integrationUniRule annotationSAAS annotation, DNA recombinationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-3740-MONOMER.
BANT261594:GJ7F-3857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine recombinase XerCUniRule annotation
Gene namesi
Name:xerCUniRule annotationImported
Ordered Locus Names:GBAA_3969Imported
ORF Names:AB163_23610Imported, AB164_19130Imported, AB165_14045Imported, AB166_06010Imported, AB167_23905Imported, AB168_27210Imported, AB169_02925Imported, AB170_11960Imported, AB171_07740Imported, AB893_19265Imported, ADT20_07780Imported, ADT21_16915Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000037132 Componenti: Unassembled WGS sequence UP000036891 Componenti: Unassembled WGS sequence UP000037502 Componenti: Unassembled WGS sequence UP000037044 Componenti: Unassembled WGS sequence UP000036858 Componenti: Unassembled WGS sequence UP000000594 Componenti: Chromosome UP000037383 Componenti: Unassembled WGS sequence UP000037060 Componenti: Unassembled WGS sequence UP000037296 Componenti: Unassembled WGS sequence UP000037367 Componenti: Unassembled WGS sequence UP000037483 Componenti: Unassembled WGS sequence UP000037079 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi198094.BA_3969.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9084Phage_int_SAM_1InterPro annotationAdd
BLAST
Domaini111 – 285175Phage_integraseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 'phage' integrase family. XerC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4974. LUCA.
ENOG4105C13. Bacteria.
HOGENOMiHOG000045294.
KOiK03733.
OMAiDRTHPRS.
OrthoDBiEOG6PZXFP.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011931. Recomb_XerC.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
TIGRFAMsiTIGR02224. recomb_XerC. 1 hit.
TIGR02225. recomb_XerD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81WK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVKKLLQLF VGYLQIERNY SKYTIASYQN DLEHFVQFME REGISSFLDI
60 70 80 90 100
TYADVRLYLT TLHDEKLARK SVARKVSSLR SLYRFLMREG YRKDNPFALA
110 120 130 140 150
SLPKKELSIP KFLYAEELEE LFEVSDTETP LGQRNQALLE LMYATGIRVS
160 170 180 190 200
ECVNLQLTDI DFAVGTILVM GKGKKQRYIP FGSYAQDALI TYIENGRKQL
210 220 230 240 250
AEKTEEQSHM VFLNAKGTPL TSRGVRYVLN ELIKKASLTM RISPHILRHT
260 270 280 290
FATHMLDEGA DLRTVQELLG HENLSTTQIY THVSKERLRS VYMKHHPRA
Length:299
Mass (Da):34,593
Last modified:June 1, 2003 - v1
Checksum:iCDCD132A824335FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT33083.1.
CP012519 Genomic DNA. Translation: ALC35884.1.
LFYJ01000068 Genomic DNA. Translation: KOM59199.1.
LFYH01000003 Genomic DNA. Translation: KOM68980.1.
LFYG01000012 Genomic DNA. Translation: KOM72893.1.
LFYI01000025 Genomic DNA. Translation: KOM76722.1.
LFYF01000022 Genomic DNA. Translation: KOM83132.1.
LGIE01000010 Genomic DNA. Translation: KOM93863.1.
LGIF01000018 Genomic DNA. Translation: KON05973.1.
LGIG01000014 Genomic DNA. Translation: KON18019.1.
LGID01000085 Genomic DNA. Translation: KON22363.1.
LHUN01000026 Genomic DNA. Translation: KOR59217.1.
LHUO01000006 Genomic DNA. Translation: KOR68888.1.
RefSeqiWP_001101226.1. NZ_LHUO01000006.1.

Genome annotation databases

EnsemblBacteriaiAAT33083; AAT33083; GBAA_3969.
AJG30479; AJG30479; TM00_19280.
KEGGibanh:HYU01_19395.
bar:GBAA_3969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT33083.1.
CP012519 Genomic DNA. Translation: ALC35884.1.
LFYJ01000068 Genomic DNA. Translation: KOM59199.1.
LFYH01000003 Genomic DNA. Translation: KOM68980.1.
LFYG01000012 Genomic DNA. Translation: KOM72893.1.
LFYI01000025 Genomic DNA. Translation: KOM76722.1.
LFYF01000022 Genomic DNA. Translation: KOM83132.1.
LGIE01000010 Genomic DNA. Translation: KOM93863.1.
LGIF01000018 Genomic DNA. Translation: KON05973.1.
LGIG01000014 Genomic DNA. Translation: KON18019.1.
LGID01000085 Genomic DNA. Translation: KON22363.1.
LHUN01000026 Genomic DNA. Translation: KOR59217.1.
LHUO01000006 Genomic DNA. Translation: KOR68888.1.
RefSeqiWP_001101226.1. NZ_LHUO01000006.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_3969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT33083; AAT33083; GBAA_3969.
AJG30479; AJG30479; TM00_19280.
KEGGibanh:HYU01_19395.
bar:GBAA_3969.

Phylogenomic databases

eggNOGiCOG4974. LUCA.
ENOG4105C13. Bacteria.
HOGENOMiHOG000045294.
KOiK03733.
OMAiDRTHPRS.
OrthoDBiEOG6PZXFP.

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-3740-MONOMER.
BANT261594:GJ7F-3857-MONOMER.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011931. Recomb_XerC.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
TIGRFAMsiTIGR02224. recomb_XerC. 1 hit.
TIGR02225. recomb_XerD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames AncestorImported and Ames ancestorImported.
  2. "Draft genome sequence of Bacillus anthracis Larissa associated with a case of cutaneous anthrax in Greece."
    Grass G., Hanczaruk M., Antwerpen M.H.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LarissaImported.
  3. "Draft genome sequence of Bacillus anthracis strain K0021."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K0021Imported.
  4. "Draft genome sequence of Bacillus anthracis strain K1129."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K1129Imported.
  5. "Draft genome sequence of Bacillus anthracis strain K1285."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K1285Imported.
  6. "Draft genome sequence of Bacillus anthracis strain K2129."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K2129Imported.
  7. "Draft genome sequence of Bacillus anthracis strain K2883."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K2883Imported.
  8. "Draft genome sequence of Bacillus anthracis strain K3974."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K3974Imported.
  9. "Draft genome sequence of Bacillus anthracis strain K4834."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K4834Imported.
  10. "Draft genome sequence of Bacillus anthracis strain K8215."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K8215Imported.
  11. "Draft genome sequence of Bacillus anthracis strain PAK-1."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PAK-1Imported.
  12. Hoefler B.C., Straight P.D.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: K0021Imported, K1129Imported, K1285Imported, K2129Imported, K2883Imported, K3974Imported, K4834Imported, K8215Imported and PAK-1Imported.
  13. "Draft genome sequence of Bacillus anthracis strain A0021."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0021Imported.
  14. "Draft genome sequence of Bacillus anthracis strain A0389."
    Consortium for Microbial Forensics and Genomics (microFORGE)
    Knight B.M., O'Shea R.M., Jones B.A., Roberts D.P., Lin D., Hari K., Winegar R.A.
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0389Imported.
  15. "MeaNS - Measles Nucleotide Surveillance Program."
    Tran T., Druce J.
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A0021Imported and A0389Imported.

Entry informationi

Entry nameiQ81WK4_BACAN
AccessioniPrimary (citable) accession number: Q81WK4
Secondary accession number(s): E9QX54
, E9QX55, Q6HUQ5, Q6KNY6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: January 20, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.