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Q81WK4

- Q81WK4_BACAN

UniProt

Q81WK4 - Q81WK4_BACAN

Protein

Tyrosine recombinase XerC

Gene

xerC

Organism
Bacillus anthracis
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei148 – 1481UniRule annotation
    Active sitei172 – 1721UniRule annotation
    Active sitei245 – 2451UniRule annotation
    Active sitei248 – 2481UniRule annotation
    Active sitei271 – 2711UniRule annotation
    Active sitei280 – 2801O-(3'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. tyrosine-based site-specific recombinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-HAMAP
    4. transposition, DNA-mediated Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotationSAAS annotation, Chromosome partitionUniRule annotationSAAS annotation, DNA integrationUniRule annotationSAAS annotation, DNA recombinationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBANT260799:GJAJ-3740-MONOMER.
    BANT261594:GJ7F-3857-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine recombinase XerCUniRule annotation
    Gene namesi
    Name:xerCUniRule annotationImported
    Ordered Locus Names:BA_3969Imported, BAS3682Imported, GBAA_3969Imported
    OrganismiBacillus anthracisImported
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000005639: Chromosome, UP000000594: Chromosome, UP000000427: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi198094.BA_3969.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 'phage' integrase family. XerC subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000045294.
    KOiK03733.
    OMAiRIVLMGL.
    OrthoDBiEOG6PZXFP.

    Family and domain databases

    Gene3Di1.10.150.130. 1 hit.
    1.10.443.10. 1 hit.
    HAMAPiMF_01808. Recomb_XerC.
    InterProiIPR011010. DNA_brk_join_enz.
    IPR013762. Integrase-like_cat-core.
    IPR002104. Integrase_catalytic.
    IPR023109. Integrase_recombinase_N.
    IPR004107. Integrase_SAM-like_N.
    IPR011931. Recomb_XerC.
    IPR011932. Recomb_XerD.
    IPR023009. Tyrosine_recombinase_XerC/XerD.
    [Graphical view]
    PfamiPF02899. Phage_int_SAM_1. 1 hit.
    PF00589. Phage_integrase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56349. SSF56349. 1 hit.
    TIGRFAMsiTIGR02224. recomb_XerC. 1 hit.
    TIGR02225. recomb_XerD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q81WK4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVKKLLQLF VGYLQIERNY SKYTIASYQN DLEHFVQFME REGISSFLDI    50
    TYADVRLYLT TLHDEKLARK SVARKVSSLR SLYRFLMREG YRKDNPFALA 100
    SLPKKELSIP KFLYAEELEE LFEVSDTETP LGQRNQALLE LMYATGIRVS 150
    ECVNLQLTDI DFAVGTILVM GKGKKQRYIP FGSYAQDALI TYIENGRKQL 200
    AEKTEEQSHM VFLNAKGTPL TSRGVRYVLN ELIKKASLTM RISPHILRHT 250
    FATHMLDEGA DLRTVQELLG HENLSTTQIY THVSKERLRS VYMKHHPRA 299
    Length:299
    Mass (Da):34,593
    Last modified:June 1, 2003 - v1
    Checksum:iCDCD132A824335FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP27698.1.
    AE017334 Genomic DNA. Translation: AAT33083.1.
    AE017225 Genomic DNA. Translation: AAT55984.1.
    RefSeqiNP_846212.1. NC_003997.3.
    YP_020608.1. NC_007530.2.
    YP_029933.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP27698; AAP27698; BA_3969.
    AAT33083; AAT33083; GBAA_3969.
    AAT55984; AAT55984; BAS3682.
    GeneIDi1086787.
    2818793.
    2850972.
    KEGGiban:BA_3969.
    bar:GBAA_3969.
    bat:BAS3682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP27698.1 .
    AE017334 Genomic DNA. Translation: AAT33083.1 .
    AE017225 Genomic DNA. Translation: AAT55984.1 .
    RefSeqi NP_846212.1. NC_003997.3.
    YP_020608.1. NC_007530.2.
    YP_029933.1. NC_005945.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_3969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP27698 ; AAP27698 ; BA_3969 .
    AAT33083 ; AAT33083 ; GBAA_3969 .
    AAT55984 ; AAT55984 ; BAS3682 .
    GeneIDi 1086787.
    2818793.
    2850972.
    KEGGi ban:BA_3969.
    bar:GBAA_3969.
    bat:BAS3682.

    Phylogenomic databases

    HOGENOMi HOG000045294.
    KOi K03733.
    OMAi RIVLMGL.
    OrthoDBi EOG6PZXFP.

    Enzyme and pathway databases

    BioCyci BANT260799:GJAJ-3740-MONOMER.
    BANT261594:GJ7F-3857-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.130. 1 hit.
    1.10.443.10. 1 hit.
    HAMAPi MF_01808. Recomb_XerC.
    InterProi IPR011010. DNA_brk_join_enz.
    IPR013762. Integrase-like_cat-core.
    IPR002104. Integrase_catalytic.
    IPR023109. Integrase_recombinase_N.
    IPR004107. Integrase_SAM-like_N.
    IPR011931. Recomb_XerC.
    IPR011932. Recomb_XerD.
    IPR023009. Tyrosine_recombinase_XerC/XerD.
    [Graphical view ]
    Pfami PF02899. Phage_int_SAM_1. 1 hit.
    PF00589. Phage_integrase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56349. SSF56349. 1 hit.
    TIGRFAMsi TIGR02224. recomb_XerC. 1 hit.
    TIGR02225. recomb_XerD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AmesImported, Ames ancestor and Sterne.
    2. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate PortonImported, Ames AncestorImported, Ames ancestorImported and SterneImported.
    4. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AmesImported.

    Entry informationi

    Entry nameiQ81WK4_BACAN
    AccessioniPrimary (citable) accession number: Q81WK4
    Secondary accession number(s): E9QX54
    , E9QX55, Q6HUQ5, Q6KNY6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3