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Protein

Ribonuclease 3

Gene

rnc

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61MagnesiumUniRule annotation1
Active sitei65UniRule annotation1
Metal bindingi134MagnesiumUniRule annotation1
Active sitei137UniRule annotation1
Metal bindingi137MagnesiumUniRule annotation1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ribonuclease III activity Source: TIGR
  • rRNA binding Source: UniProtKB-KW

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • RNA processing Source: TIGR
  • rRNA catabolic process Source: InterPro
  • rRNA processing Source: UniProtKB-KW
  • tRNA processing Source: UniProtKB-KW

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Synonyms:rncS
Ordered Locus Names:BA_3987, GBAA_3987, BAS3700
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803721 – 245Ribonuclease 3Add BLAST245

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi260799.BAS3700

Structurei

3D structure databases

ProteinModelPortaliQ81WI8
SMRiQ81WI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 148RNase IIIUniRule annotationAdd BLAST130
Domaini174 – 243DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q81WI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYRKYREKK YETKYREAFK LFQEKIGITF TDEKLLIQAF THSSYVNEHR
60 70 80 90 100
KKPHEDNERL EFLGDAVLEL TVSQYLFQKY PTMSEGELTK LRAAIVCEPS
110 120 130 140 150
LVRFANELSF GSLVLLGKGE EMTGGRERPA LLADVFEAFI GALYLDQGLE
160 170 180 190 200
TVWGFLKEIV YPKINEGAFS HVMDYKSQLQ ELIQRDGSGN IEYQILQEKG
210 220 230 240
PAHNREFVSR VTLNNVALGL GSGKSKKEAE QQAAAEALKK LKEQL
Length:245
Mass (Da):27,993
Last modified:June 1, 2003 - v1
Checksum:i7249553E3D386DBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27715.1
AE017334 Genomic DNA Translation: AAT33102.1
AE017225 Genomic DNA Translation: AAT56002.1
RefSeqiNP_846229.1, NC_003997.3
WP_001146873.1, NZ_NVHS01000028.1
YP_029951.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP27715; AAP27715; BA_3987
AAT33102; AAT33102; GBAA_3987
AAT56002; AAT56002; BAS3700
GeneIDi1087539
2849362
KEGGiban:BA_3987
bar:GBAA_3987
bat:BAS3700
PATRICifig|198094.11.peg.3957

Similar proteinsi

Entry informationi

Entry nameiRNC_BACAN
AccessioniPrimary (citable) accession number: Q81WI8
Secondary accession number(s): Q6HUN7, Q6KNX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health