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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:BA_4004, GBAA_4004, BAS3717
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829101 – 314Methionyl-tRNA formyltransferaseAdd BLAST314

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS3717

Structurei

Secondary structure

1314
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi13 – 22Combined sources10
Beta strandi26 – 31Combined sources6
Turni39 – 42Combined sources4
Helixi48 – 55Combined sources8
Helixi69 – 78Combined sources10
Beta strandi81 – 87Combined sources7
Helixi94 – 97Combined sources4
Beta strandi104 – 110Combined sources7
Beta strandi114 – 118Combined sources5
Helixi120 – 126Combined sources7
Beta strandi130 – 138Combined sources9
Beta strandi148 – 155Combined sources8
Helixi162 – 185Combined sources24
Helixi196 – 198Combined sources3
Helixi207 – 210Combined sources4
Helixi218 – 226Combined sources9
Turni227 – 232Combined sources6
Beta strandi234 – 238Combined sources5
Beta strandi241 – 252Combined sources12
Beta strandi261 – 265Combined sources5
Beta strandi270 – 272Combined sources3
Beta strandi275 – 287Combined sources13
Helixi295 – 301Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IQFX-ray2.40A/B/C/D1-314[»]
ProteinModelPortaliQ81WH2
SMRiQ81WH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

Q81WH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVVFMGTP DFSVPVLRRL IEDGYDVIGV VTQPDRPVGR KKVLTPTPVK
60 70 80 90 100
VEAEKHGIPV LQPLRIREKD EYEKVLALEP DLIVTAAFGQ IVPNEILEAP
110 120 130 140 150
KYGCINVHAS LLPELRGGAP IHYAIMEGKE KTGITIMYMV EKLDAGDILT
160 170 180 190 200
QVEVEIEERE TTGSLFDKLS EAGAHLLSKT VPLLIQGKLE PIKQNEEEVT
210 220 230 240 250
FAYNIKREQE KIDWTKTGEE VYNHIRGLNP WPVAYTTLAG QVVKVWWGEK
260 270 280 290 300
VPVTKSAEAG TIVAIEEDGF VVATGNETGV KITELQPSGK KRMSCSQFLR
310
GTKPEIGTKL GENA
Length:314
Mass (Da):34,736
Last modified:June 1, 2003 - v1
Checksum:i8E81D02492DABEE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27732.1
AE017334 Genomic DNA Translation: AAT33120.1
AE017225 Genomic DNA Translation: AAT56019.1
RefSeqiNP_846246.1, NC_003997.3
WP_000598790.1, NZ_PPES01000027.1
YP_029968.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP27732; AAP27732; BA_4004
AAT33120; AAT33120; GBAA_4004
AAT56019; AAT56019; BAS3717
GeneIDi1086742
2852995
KEGGiban:BA_4004
bar:GBAA_4004
bat:BAS3717
PATRICifig|198094.11.peg.3974

Similar proteinsi

Entry informationi

Entry nameiFMT_BACAN
AccessioniPrimary (citable) accession number: Q81WH2
Secondary accession number(s): Q6HUM0, Q6KNV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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