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Q81WH1

- DEF1_BACAN

UniProt

Q81WH1 - DEF1_BACAN

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Protein

Peptide deformylase 1

Gene

def1

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe(2+) ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901IronUniRule annotation
Metal bindingi132 – 1321IronUniRule annotation
Active sitei133 – 1331UniRule annotation
Metal bindingi136 – 1361IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-3776-MONOMER.
BANT261594:GJ7F-3893-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 1UniRule annotation
Alternative name(s):
Polypeptide deformylase 1UniRule annotation
Gene namesi
Name:def1UniRule annotation
Ordered Locus Names:BA_4005, GBAA_4005, BAS3718
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Peptide deformylase 1PRO_0000082733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_4005.

Structurei

3D structure databases

ProteinModelPortaliQ81WH1.
SMRiQ81WH1. Positions 1-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
KOiK01462.
OMAiGYLYIDR.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81WH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVLEIVKHP NEVLETPCER VINFDKKLVK LLKDMHETML IADGVGLAAP
60 70 80 90 100
QVGVSLQVAV VDIGDDTGKI ELINPSILEK RGEQVGPEGC LSFPGLYGEV
110 120 130 140 150
ERADYIKVRA QNRRGKVFLL EAEGLLARAI QHEIDHLHGV LFTSKVTRYY

EENELE
Length:156
Mass (Da):17,388
Last modified:June 1, 2003 - v1
Checksum:i038E375C2A963C87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27733.1.
AE017334 Genomic DNA. Translation: AAT33121.1.
AE017225 Genomic DNA. Translation: AAT56020.1.
RefSeqiNP_846247.1. NC_003997.3.
WP_000279469.1. NZ_JHDR01000018.1.
YP_020646.1. NC_007530.2.
YP_029969.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27733; AAP27733; BA_4005.
AAT33121; AAT33121; GBAA_4005.
AAT56020; AAT56020; BAS3718.
GeneIDi1086728.
2816204.
2852977.
KEGGiban:BA_4005.
bar:GBAA_4005.
bat:BAS3718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27733.1 .
AE017334 Genomic DNA. Translation: AAT33121.1 .
AE017225 Genomic DNA. Translation: AAT56020.1 .
RefSeqi NP_846247.1. NC_003997.3.
WP_000279469.1. NZ_JHDR01000018.1.
YP_020646.1. NC_007530.2.
YP_029969.1. NC_005945.1.

3D structure databases

ProteinModelPortali Q81WH1.
SMRi Q81WH1. Positions 1-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_4005.

Protocols and materials databases

DNASUi 1086728.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP27733 ; AAP27733 ; BA_4005 .
AAT33121 ; AAT33121 ; GBAA_4005 .
AAT56020 ; AAT56020 ; BAS3718 .
GeneIDi 1086728.
2816204.
2852977.
KEGGi ban:BA_4005.
bar:GBAA_4005.
bat:BAS3718.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
KOi K01462.
OMAi GYLYIDR.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci BANT260799:GJAJ-3776-MONOMER.
BANT261594:GJ7F-3893-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiDEF1_BACAN
AccessioniPrimary (citable) accession number: Q81WH1
Secondary accession number(s): Q6HUL9, Q6KNV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3