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Q81WH1

- DEF1_BACAN

UniProt

Q81WH1 - DEF1_BACAN

Protein

Peptide deformylase 1

Gene

def1

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi90 – 901IronUniRule annotation
    Metal bindingi132 – 1321IronUniRule annotation
    Active sitei133 – 1331UniRule annotation
    Metal bindingi136 – 1361IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBANT260799:GJAJ-3776-MONOMER.
    BANT261594:GJ7F-3893-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDF 1UniRule annotation
    Alternative name(s):
    Polypeptide deformylase 1UniRule annotation
    Gene namesi
    Name:def1UniRule annotation
    Ordered Locus Names:BA_4005, GBAA_4005, BAS3718
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Peptide deformylase 1PRO_0000082733Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198094.BA_4005.

    Structurei

    3D structure databases

    ProteinModelPortaliQ81WH1.
    SMRiQ81WH1. Positions 1-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OMAiGYLYIDR.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q81WH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLEIVKHP NEVLETPCER VINFDKKLVK LLKDMHETML IADGVGLAAP    50
    QVGVSLQVAV VDIGDDTGKI ELINPSILEK RGEQVGPEGC LSFPGLYGEV 100
    ERADYIKVRA QNRRGKVFLL EAEGLLARAI QHEIDHLHGV LFTSKVTRYY 150
    EENELE 156
    Length:156
    Mass (Da):17,388
    Last modified:June 1, 2003 - v1
    Checksum:i038E375C2A963C87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP27733.1.
    AE017334 Genomic DNA. Translation: AAT33121.1.
    AE017225 Genomic DNA. Translation: AAT56020.1.
    RefSeqiNP_846247.1. NC_003997.3.
    YP_020646.1. NC_007530.2.
    YP_029969.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP27733; AAP27733; BA_4005.
    AAT33121; AAT33121; GBAA_4005.
    AAT56020; AAT56020; BAS3718.
    GeneIDi1086728.
    2816204.
    2852977.
    KEGGiban:BA_4005.
    bar:GBAA_4005.
    bat:BAS3718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP27733.1 .
    AE017334 Genomic DNA. Translation: AAT33121.1 .
    AE017225 Genomic DNA. Translation: AAT56020.1 .
    RefSeqi NP_846247.1. NC_003997.3.
    YP_020646.1. NC_007530.2.
    YP_029969.1. NC_005945.1.

    3D structure databases

    ProteinModelPortali Q81WH1.
    SMRi Q81WH1. Positions 1-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_4005.

    Protocols and materials databases

    DNASUi 1086728.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP27733 ; AAP27733 ; BA_4005 .
    AAT33121 ; AAT33121 ; GBAA_4005 .
    AAT56020 ; AAT56020 ; BAS3718 .
    GeneIDi 1086728.
    2816204.
    2852977.
    KEGGi ban:BA_4005.
    bar:GBAA_4005.
    bat:BAS3718.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OMAi GYLYIDR.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci BANT260799:GJAJ-3776-MONOMER.
    BANT261594:GJ7F-3893-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiDEF1_BACAN
    AccessioniPrimary (citable) accession number: Q81WH1
    Secondary accession number(s): Q6HUL9, Q6KNV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3