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Protein

Peptide deformylase 1

Gene

def1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90IronUniRule annotation1
Metal bindingi132IronUniRule annotation1
Active sitei133UniRule annotation1
Metal bindingi136IronUniRule annotation1

GO - Molecular functioni

  • formylmethionine deformylase activity Source: TIGR
  • metal ion binding Source: UniProtKB-KW
  • peptide deformylase activity Source: UniProtKB-EC

GO - Biological processi

  • cellular protein modification process Source: TIGR
  • translation Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 1UniRule annotation
Alternative name(s):
Polypeptide deformylase 1UniRule annotation
Gene namesi
Name:def1UniRule annotation
Ordered Locus Names:BA_4005, GBAA_4005, BAS3718
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827331 – 156Peptide deformylase 1Add BLAST156

Proteomic databases

PRIDEiQ81WH1

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS3718

Structurei

3D structure databases

ProteinModelPortaliQ81WH1
SMRiQ81WH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
KOiK01462
OMAiVCIQHEI

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q81WH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLEIVKHP NEVLETPCER VINFDKKLVK LLKDMHETML IADGVGLAAP
60 70 80 90 100
QVGVSLQVAV VDIGDDTGKI ELINPSILEK RGEQVGPEGC LSFPGLYGEV
110 120 130 140 150
ERADYIKVRA QNRRGKVFLL EAEGLLARAI QHEIDHLHGV LFTSKVTRYY

EENELE
Length:156
Mass (Da):17,388
Last modified:June 1, 2003 - v1
Checksum:i038E375C2A963C87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27733.1
AE017334 Genomic DNA Translation: AAT33121.1
AE017225 Genomic DNA Translation: AAT56020.1
RefSeqiNP_846247.1, NC_003997.3
WP_000279469.1, NZ_PPES01000027.1
YP_029969.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP27733; AAP27733; BA_4005
AAT33121; AAT33121; GBAA_4005
AAT56020; AAT56020; BAS3718
GeneIDi1086728
2852977
KEGGiban:BA_4005
bar:GBAA_4005
bat:BAS3718
PATRICifig|198094.11.peg.3975

Similar proteinsi

Entry informationi

Entry nameiDEF1_BACAN
AccessioniPrimary (citable) accession number: Q81WH1
Secondary accession number(s): Q6HUL9, Q6KNV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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