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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase large chain (carB)
  2. Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:BA_4028, GBAA_4028, BAS3740
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130891 – 304Aspartate carbamoyltransferaseAdd BLAST304

Interactioni

Protein-protein interaction databases

IntActiQ81WE9, 5 interactors
STRINGi260799.BAS3740

Structurei

3D structure databases

ProteinModelPortaliQ81WE9
SMRiQ81WE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT Bacteria
COG0540 LUCA
HOGENOMiHOG000022685
KOiK00609
OMAiWCDVANM

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q81WE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLLTMSEL SEVEISEILK DAEDFANGKE SKTTEQTFVA NLFFENSTRT
60 70 80 90 100
RFSFEVAEKR LGLDVLNFSA DASSVQKGET LYDTIRTLES IGTKAVVIRH
110 120 130 140 150
EQDRYFDELK DQVNIPILNA GDGCGNHPTQ CLLDLLTIKQ EFGRFEGLKI
160 170 180 190 200
AIVGDVRHSR VARSNAEALT KLGATIYFAS PEEWKDEDNT FGTYKPLDEL
210 220 230 240 250
VPEVDVMMLL RVQHERHDHY ETDIMKEYHE KHGLTVEREK RMKEGSIIMH
260 270 280 290 300
PAPVNRDVEI ASELVECERS RIFKQMENGV YVRMAVLKRA LPNVLGGMKH

ELFV
Length:304
Mass (Da):34,722
Last modified:June 1, 2003 - v1
Checksum:i7E4FE09447EE773E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27755.1
AE017334 Genomic DNA Translation: AAT33145.1
AE017225 Genomic DNA Translation: AAT56042.1
RefSeqiNP_846269.1, NC_003997.3
WP_000018849.1, NZ_PPES01000027.1
YP_029991.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP27755; AAP27755; BA_4028
AAT33145; AAT33145; GBAA_4028
AAT56042; AAT56042; BAS3740
GeneIDi1086640
2852925
31628659
KEGGiban:BA_4028
bar:GBAA_4028
bat:BAS3740
PATRICifig|198094.11.peg.3999

Similar proteinsi

Entry informationi

Entry nameiPYRB_BACAN
AccessioniPrimary (citable) accession number: Q81WE9
Secondary accession number(s): Q6HUJ7, Q6KNT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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