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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase (glutamine-hydrolyzing) (ABW01_09345), Carbamoyl-phosphate synthase (glutamine-hydrolyzing) (carB), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC), Dihydroorotase (pyrC), Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciANTHRA:PYRB-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:BA_4028, GBAA_4028, BAS3740
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130891 – 304Aspartate carbamoyltransferaseAdd BLAST304

Interactioni

Protein-protein interaction databases

IntActiQ81WE9. 5 interactors.
STRINGi198094.BA_4028.

Structurei

3D structure databases

ProteinModelPortaliQ81WE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiGPINREI.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81WE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLLTMSEL SEVEISEILK DAEDFANGKE SKTTEQTFVA NLFFENSTRT
60 70 80 90 100
RFSFEVAEKR LGLDVLNFSA DASSVQKGET LYDTIRTLES IGTKAVVIRH
110 120 130 140 150
EQDRYFDELK DQVNIPILNA GDGCGNHPTQ CLLDLLTIKQ EFGRFEGLKI
160 170 180 190 200
AIVGDVRHSR VARSNAEALT KLGATIYFAS PEEWKDEDNT FGTYKPLDEL
210 220 230 240 250
VPEVDVMMLL RVQHERHDHY ETDIMKEYHE KHGLTVEREK RMKEGSIIMH
260 270 280 290 300
PAPVNRDVEI ASELVECERS RIFKQMENGV YVRMAVLKRA LPNVLGGMKH

ELFV
Length:304
Mass (Da):34,722
Last modified:June 1, 2003 - v1
Checksum:i7E4FE09447EE773E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27755.1.
AE017334 Genomic DNA. Translation: AAT33145.1.
AE017225 Genomic DNA. Translation: AAT56042.1.
RefSeqiNP_846269.1. NC_003997.3.
WP_000018849.1. NZ_LHUO01000006.1.
YP_029991.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27755; AAP27755; BA_4028.
AAT33145; AAT33145; GBAA_4028.
AAT56042; AAT56042; BAS3740.
GeneIDi1086640.
2852925.
KEGGiban:BA_4028.
bar:GBAA_4028.
bat:BAS3740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27755.1.
AE017334 Genomic DNA. Translation: AAT33145.1.
AE017225 Genomic DNA. Translation: AAT56042.1.
RefSeqiNP_846269.1. NC_003997.3.
WP_000018849.1. NZ_LHUO01000006.1.
YP_029991.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81WE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81WE9. 5 interactors.
STRINGi198094.BA_4028.

Protocols and materials databases

DNASUi1086640.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27755; AAP27755; BA_4028.
AAT33145; AAT33145; GBAA_4028.
AAT56042; AAT56042; BAS3740.
GeneIDi1086640.
2852925.
KEGGiban:BA_4028.
bar:GBAA_4028.
bat:BAS3740.

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiGPINREI.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.
BioCyciANTHRA:PYRB-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRB_BACAN
AccessioniPrimary (citable) accession number: Q81WE9
Secondary accession number(s): Q6HUJ7, Q6KNT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.