UDP-N-acetylenolpyruvoylglucosamine reductase 1

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Reviewed, UniProtKB/Swiss-Prot Q81WD1 (MURB1_BACAN)

Last modified February 9, 2010. Version 53. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductase 1
    EC=1.1.1.158
Alternative name(s):
    UDP-N-acetylmuramate dehydrogenase 1

Gene names

Name:	murB1
Synonyms:	murB-1
Ordered Locus Names:	BA_4048, GBAA_4048, BAS3760

Organism

Bacillus anthracis [Complete proteome] [HAMAP]

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

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Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP MF_00037
Catalytic activity	UDP-N-acetylmuramate + NADP⁺ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037
Cofactor	FAD By similarity. HAMAP MF_00037
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037
Subcellular location	Cytoplasm Probable HAMAP MF_00037.
Sequence similarities	Belongs to the murB family. Contains 1 FAD-binding PCMH-type domain.

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Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro UDP-N-acetylmuramate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 301

301

UDP-N-acetylenolpyruvoylglucosamine reductase 1 HAMAP MF_00037

PRO_0000179172

Regions

Domain

29 – 196

168

FAD-binding PCMH-type

Sites

Active site

174

By similarity

Active site

225

Proton donor By similarity

Active site

295

By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q81WD1-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7455EA4AA2E2FC1B
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FASTA

301

33,016

        10         20         30         40         50         60 
MEQLVNELIQ ANVGRVLVDE PLARYTTMKI GGPADILIVP KRVAGIEKTL QLVKKYKTKW 

        70         80         90        100        110        120 
TVIGRGSNLL VSDLGIEGVV IRLGEGLDHL EVEKHRVRVG GGYPLIKLST LLSRQGLAGL 

       130        140        150        160        170        180 
EFASGIPGSV GGAVYMNAGA HKSDISNILS KALILFEDGT IDWLTHGEME FSYRTSVLQT 

       190        200        210        220        230        240 
KRPGIVLEAE FQLQIGERER IVSVMQKNKD YRRETQPWNH PCAGSVFRNP TPYFAGDLIE 

       250        260        270        280        290        300 
KAGLRGYQIG GAQISEMHGN FIINTGGASA QDVLSLIALI KQTIKDKFGV EMHTEVEIIG 


R

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References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP27774.1. AE017334 Genomic DNA. Translation: AAT33165.1. AE017225 Genomic DNA. Translation: AAT56062.1.
RefSeq	NP_846288.1. YP_020690.1. YP_030011.1.
3D structure databases
SMR	Q81WD1. Positions 4-301.
ModBase	Search...
Genome annotation databases
GeneID	1087051. 2819707. 2851712.
GenomeReviews	Gene locus BA_4048 in contig AE016879_GR. Gene locus BAS3760 in contig AE017225_GR. Gene locus GBAA_4048 in contig AE017334_GR.
KEGG	ban:BA4048. bar:GBAA4048. bat:BAS3760.
TIGR	BA_4048. GBAA_4048.
Phylogenomic databases
HOGENOM	HBG686573.
OMA	ARYTTMK.
Enzyme and pathway databases
BioCyc	BANT260799:BAS3760-MONOMER. BANT261594:GBAA4048-MONOMER.
BRENDA	1.1.1.158. 267517.
Family and domain databases
HAMAP	MF_00037. MurB. [Tree]
InterPro	IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR006094. Oxid_FAD_bind_N. [Graphical view]
Gene3D	G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.90.78.10. MurB_C. 1 hit.
PANTHER	PTHR21071. MurB. 1 hit.
Pfam	PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00179. murB. 1 hit.
PROSITE	PS51387. FAD_PCMH. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

MURB1_BACAN

Accession

Primary (citable) accession number: Q81WD1
Secondary accession number(s): Q6HUH7, Q6KNR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents