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Q81WD1 (MURB1_BACAN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase 1
EC=1.1.1.158
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase 1
Gene names
Name:murB1
Synonyms:murB-1
Ordered Locus Names:BA_4048, GBAA_4048, BAS3760
OrganismBacillus anthracis
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm By similarity HAMAP MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301UDP-N-acetylenolpyruvoylglucosamine reductase 1 HAMAP MF_00037
PRO_0000179172

Regions

Domain29 – 196168FAD-binding PCMH-type

Sites

Active site1741 By similarity
Active site2251Proton donor By similarity
Active site2951 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q81WD1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7455EA4AA2E2FC1B

FASTA30133,016
        10         20         30         40         50         60 
MEQLVNELIQ ANVGRVLVDE PLARYTTMKI GGPADILIVP KRVAGIEKTL QLVKKYKTKW 

        70         80         90        100        110        120 
TVIGRGSNLL VSDLGIEGVV IRLGEGLDHL EVEKHRVRVG GGYPLIKLST LLSRQGLAGL 

       130        140        150        160        170        180 
EFASGIPGSV GGAVYMNAGA HKSDISNILS KALILFEDGT IDWLTHGEME FSYRTSVLQT 

       190        200        210        220        230        240 
KRPGIVLEAE FQLQIGERER IVSVMQKNKD YRRETQPWNH PCAGSVFRNP TPYFAGDLIE 

       250        260        270        280        290        300 
KAGLRGYQIG GAQISEMHGN FIINTGGASA QDVLSLIALI KQTIKDKFGV EMHTEVEIIG 


R

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References

[1]"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. expand/collapse author list , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
Nature 423:81-86(2003) [PubMed: 12721629] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames / isolate Porton.
[2]"Bacillus anthracis comparative genomics."
Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor.
[3]"Complete genome sequence of Bacillus anthracis Sterne."
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sterne.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016879 Genomic DNA. Translation: AAP27774.1.
AE017334 Genomic DNA. Translation: AAT33165.1.
AE017225 Genomic DNA. Translation: AAT56062.1.
RefSeqNP_846288.1. NC_003997.3.
YP_020690.1. NC_007530.2.
YP_030011.1. NC_005945.1.

3D structure databases

ProteinModelPortalQ81WD1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000008666; EBBACP00000008422; EBBACG00000008658.
EBBACT00000014590; EBBACP00000014211; EBBACG00000014582.
EBBACT00000021148; EBBACP00000020633; EBBACG00000021139.
GeneID1087051.
2819707.
2851712.
GenomeReviewsGene locus BA_4048 in contig AE016879_GR.
Gene locus BAS3760 in contig AE017225_GR.
Gene locus GBAA_4048 in contig AE017334_GR.
KEGGban:BA_4048.
bar:GBAA_4048.
bat:BAS3760.
TIGRBA_4048.
GBAA_4048.

Phylogenomic databases

GeneTreeEBGT00050000001391.
HOGENOMHBG686573.
OMAEANVGRV.
ProtClustDBPRK13905.

Enzyme and pathway databases

BioCycBANT260799:BAS3760-MONOMER.
BANT261594:GBAA4048-MONOMER.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
KOK00075.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. MurB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB1_BACAN
AccessionPrimary (citable) accession number: Q81WD1
Secondary accession number(s): Q6HUH7, Q6KNR3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents