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Q81W73 (FOSB2_BACAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothiol transferase FosB 2

EC=2.5.1.-
Alternative name(s):
Fosfomycin resistance protein 2
Gene names
Name:fosB2
Synonyms:fosB-2
Ordered Locus Names:BA_4109, GBAA_4109, BAS3818
OrganismBacillus anthracis [Reference proteome] [HAMAP]
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor By similarity. HAMAP-Rule MF_01512

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01512

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01512

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01512.

Sequence similarities

Belongs to the fosfomycin resistance protein family. FosB subfamily.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

transferase activity, transferring alkyl or aryl (other than methyl) groups

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 139139Metallothiol transferase FosB 2 HAMAP-Rule MF_01512
PRO_0000164023

Sites

Metal binding71Magnesium By similarity
Metal binding661Magnesium By similarity
Metal binding1151Magnesium By similarity

Secondary structure

........................... 139
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q81W73 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E2F02F9F77690B4C

FASTA13916,525
        10         20         30         40         50         60 
MLQGINHICF SVSNLEKSIE FYQKILQAKL LVKGRKLAYF DLNGLWIALN VEEDIPRNEI 

        70         80         90        100        110        120 
KQSYTHMAFT VTNEALDHLK EVLIQNDVNI LPGRERDERD QRSLYFTDPD GHKFEFHTGT 

       130 
LQNRLEYYKE DKKHMTFYI 

« Hide

References

[1]"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. expand/collapse author list , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames / isolate Porton.
[2]"The complete genome sequence of Bacillus anthracis Ames 'Ancestor'."
Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.
J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor.
[3]"Complete genome sequence of Bacillus anthracis Sterne."
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sterne.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016879 Genomic DNA. Translation: AAP27834.1.
AE017334 Genomic DNA. Translation: AAT33228.1.
AE017225 Genomic DNA. Translation: AAT56119.1.
RefSeqNP_846348.1. NC_003997.3.
YP_020753.1. NC_007530.2.
YP_030068.1. NC_005945.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4IR0X-ray1.60A/B1-139[»]
4JD1X-ray1.70A/B1-139[»]
ProteinModelPortalQ81W73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198094.BA_4109.

Protocols and materials databases

DNASU1086311.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP27834; AAP27834; BA_4109.
AAT33228; AAT33228; GBAA_4109.
AAT56119; AAT56119; BAS3818.
GeneID1086311.
2818084.
2851236.
KEGGban:BA_4109.
bar:GBAA_4109.
bat:BAS3818.

Phylogenomic databases

eggNOGCOG0346.
HOGENOMHOG000232023.
KOK11210.
OMAMEDANIL.
OrthoDBEOG6VXFB2.
ProtClustDBPRK04101.

Enzyme and pathway databases

BioCycANTHRA:FOSB-2-MONOMER.
BANT260799:GJAJ-3875-MONOMER.
BANT261594:GJ7F-3996-MONOMER.

Family and domain databases

HAMAPMF_01512. FosB.
InterProIPR025870. Glyoxalase-like_dom.
IPR022858. Metallothiol_Trafse_FosB.
[Graphical view]
PfamPF12681. Glyoxalase_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOSB2_BACAN
AccessionPrimary (citable) accession number: Q81W73
Secondary accession number(s): Q6HUC0, Q6KNK7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references