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Protein

Metallothiol transferase FosB 2

Gene

fosB2

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71MagnesiumUniRule annotation
Metal bindingi66 – 661MagnesiumUniRule annotation
Metal bindingi115 – 1151MagnesiumUniRule annotation

GO - Molecular functioni

  • glutathione transferase activity Source: TIGR
  • magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  • response to antibiotic Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:FOSB-2-MONOMER.
BANT260799:GJAJ-3875-MONOMER.
BANT261594:GJ7F-3996-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothiol transferase FosB 2UniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Fosfomycin resistance protein 2UniRule annotation
Gene namesi
Name:fosB2UniRule annotation
Synonyms:fosB-2
Ordered Locus Names:BA_4109, GBAA_4109, BAS3818
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Metallothiol transferase FosB 2PRO_0000164023Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_4109.

Structurei

Secondary structure

1
139
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 137Combined sources
Helixi15 – 2410Combined sources
Beta strandi29 – 335Combined sources
Beta strandi35 – 428Combined sources
Beta strandi45 – 517Combined sources
Helixi59 – 624Combined sources
Beta strandi66 – 705Combined sources
Helixi73 – 8513Combined sources
Beta strandi89 – 913Combined sources
Helixi98 – 1003Combined sources
Beta strandi103 – 1075Combined sources
Beta strandi113 – 1175Combined sources
Helixi121 – 13111Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IR0X-ray1.60A/B1-139[»]
4JD1X-ray1.70A/B1-139[»]
5F6QX-ray1.52A/B1-139[»]
ProteinModelPortaliQ81W73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fosfomycin resistance protein family. FosB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105I9P. Bacteria.
COG0346. LUCA.
HOGENOMiHOG000232023.
KOiK11210.
OMAiNHIAFRI.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
HAMAPiMF_01512. FosB. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR022858. Metallothiol_Trafse_FosB.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81W73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQGINHICF SVSNLEKSIE FYQKILQAKL LVKGRKLAYF DLNGLWIALN
60 70 80 90 100
VEEDIPRNEI KQSYTHMAFT VTNEALDHLK EVLIQNDVNI LPGRERDERD
110 120 130
QRSLYFTDPD GHKFEFHTGT LQNRLEYYKE DKKHMTFYI
Length:139
Mass (Da):16,525
Last modified:June 1, 2003 - v1
Checksum:iE2F02F9F77690B4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27834.1.
AE017334 Genomic DNA. Translation: AAT33228.1.
AE017225 Genomic DNA. Translation: AAT56119.1.
RefSeqiNP_846348.1. NC_003997.3.
WP_000938987.1. NZ_LHUO01000006.1.
YP_030068.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27834; AAP27834; BA_4109.
AAT33228; AAT33228; GBAA_4109.
AAT56119; AAT56119; BAS3818.
GeneIDi1086311.
2851236.
KEGGiban:BA_4109.
bar:GBAA_4109.
bat:BAS3818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27834.1.
AE017334 Genomic DNA. Translation: AAT33228.1.
AE017225 Genomic DNA. Translation: AAT56119.1.
RefSeqiNP_846348.1. NC_003997.3.
WP_000938987.1. NZ_LHUO01000006.1.
YP_030068.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IR0X-ray1.60A/B1-139[»]
4JD1X-ray1.70A/B1-139[»]
5F6QX-ray1.52A/B1-139[»]
ProteinModelPortaliQ81W73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_4109.

Protocols and materials databases

DNASUi1086311.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27834; AAP27834; BA_4109.
AAT33228; AAT33228; GBAA_4109.
AAT56119; AAT56119; BAS3818.
GeneIDi1086311.
2851236.
KEGGiban:BA_4109.
bar:GBAA_4109.
bat:BAS3818.

Phylogenomic databases

eggNOGiENOG4105I9P. Bacteria.
COG0346. LUCA.
HOGENOMiHOG000232023.
KOiK11210.
OMAiNHIAFRI.

Enzyme and pathway databases

BioCyciANTHRA:FOSB-2-MONOMER.
BANT260799:GJAJ-3875-MONOMER.
BANT261594:GJ7F-3996-MONOMER.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
HAMAPiMF_01512. FosB. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR022858. Metallothiol_Trafse_FosB.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFOSB2_BACAN
AccessioniPrimary (citable) accession number: Q81W73
Secondary accession number(s): Q6HUC0, Q6KNK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.