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Q81W73

- FOSB2_BACAN

UniProt

Q81W73 - FOSB2_BACAN

Protein

Metallothiol transferase FosB 2

Gene

fosB2

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71MagnesiumUniRule annotation
    Metal bindingi66 – 661MagnesiumUniRule annotation
    Metal bindingi115 – 1151MagnesiumUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: UniProtKB-HAMAP

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciANTHRA:FOSB-2-MONOMER.
    BANT260799:GJAJ-3875-MONOMER.
    BANT261594:GJ7F-3996-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothiol transferase FosB 2UniRule annotation (EC:2.5.1.-UniRule annotation)
    Alternative name(s):
    Fosfomycin resistance protein 2UniRule annotation
    Gene namesi
    Name:fosB2UniRule annotation
    Synonyms:fosB-2
    Ordered Locus Names:BA_4109, GBAA_4109, BAS3818
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Metallothiol transferase FosB 2PRO_0000164023Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198094.BA_4109.

    Structurei

    Secondary structure

    1
    139
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 1310
    Helixi15 – 2410
    Beta strandi29 – 335
    Beta strandi35 – 428
    Beta strandi45 – 517
    Helixi59 – 624
    Beta strandi66 – 705
    Helixi73 – 8513
    Beta strandi89 – 913
    Helixi98 – 1003
    Beta strandi103 – 1075
    Beta strandi113 – 1186
    Helixi121 – 13414

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IR0X-ray1.60A/B1-139[»]
    4JD1X-ray1.70A/B1-139[»]
    ProteinModelPortaliQ81W73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the fosfomycin resistance protein family. FosB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0346.
    HOGENOMiHOG000232023.
    KOiK11210.
    OMAiHYAFSIA.
    OrthoDBiEOG6VXFB2.

    Family and domain databases

    Gene3Di3.10.180.10. 1 hit.
    HAMAPiMF_01512. FosB.
    InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR025870. Glyoxalase-like_dom.
    IPR022858. Metallothiol_Trafse_FosB.
    [Graphical view]
    PfamiPF12681. Glyoxalase_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF54593. SSF54593. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q81W73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQGINHICF SVSNLEKSIE FYQKILQAKL LVKGRKLAYF DLNGLWIALN    50
    VEEDIPRNEI KQSYTHMAFT VTNEALDHLK EVLIQNDVNI LPGRERDERD 100
    QRSLYFTDPD GHKFEFHTGT LQNRLEYYKE DKKHMTFYI 139
    Length:139
    Mass (Da):16,525
    Last modified:June 1, 2003 - v1
    Checksum:iE2F02F9F77690B4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP27834.1.
    AE017334 Genomic DNA. Translation: AAT33228.1.
    AE017225 Genomic DNA. Translation: AAT56119.1.
    RefSeqiNP_846348.1. NC_003997.3.
    YP_020753.1. NC_007530.2.
    YP_030068.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP27834; AAP27834; BA_4109.
    AAT33228; AAT33228; GBAA_4109.
    AAT56119; AAT56119; BAS3818.
    GeneIDi1086311.
    2818084.
    2851236.
    KEGGiban:BA_4109.
    bar:GBAA_4109.
    bat:BAS3818.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP27834.1 .
    AE017334 Genomic DNA. Translation: AAT33228.1 .
    AE017225 Genomic DNA. Translation: AAT56119.1 .
    RefSeqi NP_846348.1. NC_003997.3.
    YP_020753.1. NC_007530.2.
    YP_030068.1. NC_005945.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IR0 X-ray 1.60 A/B 1-139 [» ]
    4JD1 X-ray 1.70 A/B 1-139 [» ]
    ProteinModelPortali Q81W73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_4109.

    Protocols and materials databases

    DNASUi 1086311.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP27834 ; AAP27834 ; BA_4109 .
    AAT33228 ; AAT33228 ; GBAA_4109 .
    AAT56119 ; AAT56119 ; BAS3818 .
    GeneIDi 1086311.
    2818084.
    2851236.
    KEGGi ban:BA_4109.
    bar:GBAA_4109.
    bat:BAS3818.

    Phylogenomic databases

    eggNOGi COG0346.
    HOGENOMi HOG000232023.
    KOi K11210.
    OMAi HYAFSIA.
    OrthoDBi EOG6VXFB2.

    Enzyme and pathway databases

    BioCyci ANTHRA:FOSB-2-MONOMER.
    BANT260799:GJAJ-3875-MONOMER.
    BANT261594:GJ7F-3996-MONOMER.

    Family and domain databases

    Gene3Di 3.10.180.10. 1 hit.
    HAMAPi MF_01512. FosB.
    InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR025870. Glyoxalase-like_dom.
    IPR022858. Metallothiol_Trafse_FosB.
    [Graphical view ]
    Pfami PF12681. Glyoxalase_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54593. SSF54593. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiFOSB2_BACAN
    AccessioniPrimary (citable) accession number: Q81W73
    Secondary accession number(s): Q6HUC0, Q6KNK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3