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Q81W73

- FOSB2_BACAN

UniProt

Q81W73 - FOSB2_BACAN

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Protein

Metallothiol transferase FosB 2

Gene

fosB2

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71MagnesiumUniRule annotation
Metal bindingi66 – 661MagnesiumUniRule annotation
Metal bindingi115 – 1151MagnesiumUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:FOSB-2-MONOMER.
BANT260799:GJAJ-3875-MONOMER.
BANT261594:GJ7F-3996-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothiol transferase FosB 2UniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Fosfomycin resistance protein 2UniRule annotation
Gene namesi
Name:fosB2UniRule annotation
Synonyms:fosB-2
Ordered Locus Names:BA_4109, GBAA_4109, BAS3818
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Metallothiol transferase FosB 2PRO_0000164023Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_4109.

Structurei

Secondary structure

1
139
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 1310Combined sources
Helixi15 – 2410Combined sources
Beta strandi29 – 335Combined sources
Beta strandi35 – 428Combined sources
Beta strandi45 – 517Combined sources
Helixi59 – 624Combined sources
Beta strandi66 – 705Combined sources
Helixi73 – 8513Combined sources
Beta strandi89 – 913Combined sources
Helixi98 – 1003Combined sources
Beta strandi103 – 1075Combined sources
Beta strandi113 – 1186Combined sources
Helixi121 – 13414Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IR0X-ray1.60A/B1-139[»]
4JD1X-ray1.70A/B1-139[»]
ProteinModelPortaliQ81W73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fosfomycin resistance protein family. FosB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0346.
HOGENOMiHOG000232023.
KOiK11210.
OMAiHYAFSIA.
OrthoDBiEOG6VXFB2.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
HAMAPiMF_01512. FosB.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR025870. Glyoxalase-like_dom.
IPR022858. Metallothiol_Trafse_FosB.
[Graphical view]
PfamiPF12681. Glyoxalase_2. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81W73-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQGINHICF SVSNLEKSIE FYQKILQAKL LVKGRKLAYF DLNGLWIALN
60 70 80 90 100
VEEDIPRNEI KQSYTHMAFT VTNEALDHLK EVLIQNDVNI LPGRERDERD
110 120 130
QRSLYFTDPD GHKFEFHTGT LQNRLEYYKE DKKHMTFYI
Length:139
Mass (Da):16,525
Last modified:June 1, 2003 - v1
Checksum:iE2F02F9F77690B4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27834.1.
AE017334 Genomic DNA. Translation: AAT33228.1.
AE017225 Genomic DNA. Translation: AAT56119.1.
RefSeqiNP_846348.1. NC_003997.3.
WP_000938987.1. NZ_JHDR01000018.1.
YP_020753.1. NC_007530.2.
YP_030068.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27834; AAP27834; BA_4109.
AAT33228; AAT33228; GBAA_4109.
AAT56119; AAT56119; BAS3818.
GeneIDi1086311.
2818084.
2851236.
KEGGiban:BA_4109.
bar:GBAA_4109.
bat:BAS3818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27834.1 .
AE017334 Genomic DNA. Translation: AAT33228.1 .
AE017225 Genomic DNA. Translation: AAT56119.1 .
RefSeqi NP_846348.1. NC_003997.3.
WP_000938987.1. NZ_JHDR01000018.1.
YP_020753.1. NC_007530.2.
YP_030068.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IR0 X-ray 1.60 A/B 1-139 [» ]
4JD1 X-ray 1.70 A/B 1-139 [» ]
ProteinModelPortali Q81W73.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_4109.

Protocols and materials databases

DNASUi 1086311.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP27834 ; AAP27834 ; BA_4109 .
AAT33228 ; AAT33228 ; GBAA_4109 .
AAT56119 ; AAT56119 ; BAS3818 .
GeneIDi 1086311.
2818084.
2851236.
KEGGi ban:BA_4109.
bar:GBAA_4109.
bat:BAS3818.

Phylogenomic databases

eggNOGi COG0346.
HOGENOMi HOG000232023.
KOi K11210.
OMAi HYAFSIA.
OrthoDBi EOG6VXFB2.

Enzyme and pathway databases

BioCyci ANTHRA:FOSB-2-MONOMER.
BANT260799:GJAJ-3875-MONOMER.
BANT261594:GJ7F-3996-MONOMER.

Family and domain databases

Gene3Di 3.10.180.10. 1 hit.
HAMAPi MF_01512. FosB.
InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR025870. Glyoxalase-like_dom.
IPR022858. Metallothiol_Trafse_FosB.
[Graphical view ]
Pfami PF12681. Glyoxalase_2. 1 hit.
[Graphical view ]
SUPFAMi SSF54593. SSF54593. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiFOSB2_BACAN
AccessioniPrimary (citable) accession number: Q81W73
Secondary accession number(s): Q6HUC0, Q6KNK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3