Ribose-phosphate pyrophosphokinase

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Q81VZ0 (KPRS_BACAN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 65. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ribose-phosphate pyrophosphokinase
Short name=RPPK
EC=2.7.6.1

Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase

Gene names

Name:	prs
Ordered Locus Names:	BA_0049, GBAA_0049, BAS0049

Organism

Bacillus anthracis

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583_B
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00583_B.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: InterPro ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 317

317

Ribose-phosphate pyrophosphokinase HAMAP MF_00583_B

PRO_0000141106

Regions

Region

217 – 230

Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding

134

Magnesium Potential

Metal binding

136

Magnesium Potential

Metal binding

145

Magnesium Potential

Metal binding

149

Magnesium Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q81VZ0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 16414CD5645DA23A
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FASTA

317

34,836

        10         20         30         40         50         60 
MSTQYLNSNL KVFSLNSNKE LAEQIAKHIG VGLGKCSVDR FSDGEVQINI EESIRGCDVF 

        70         80         90        100        110        120 
IIQSTSFPVN EHIMELLIMI DALKRASAKT INIVIPYYGY ARQDRKARSR EPITSKLVAN 

       130        140        150        160        170        180 
LLETAGATRV ITLDLHAPQI QGFFDIPIDH LMGVPILSDY FETKGLKDIV IVSPDHGGVT 

       190        200        210        220        230        240 
RARKMADRLK APIAIIDKRR PRPNVSEVMN IIGNIEGKTA ILIDDIIDTA GTITLAANAL 

       250        260        270        280        290        300 
VENGASEVYA CCTHPVLSGP AIERIQNSNI KELVVTNSIV LPEEKKIDKV HELSVAPLIG 

       310 
EAIIRVYEEE SVSVLFN

« Hide

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP24104.1. AE017334 Genomic DNA. Translation: AAT29127.1. AE017225 Genomic DNA. Translation: AAT52387.1.
RefSeq	NP_842618.1. NC_003997.3. YP_016652.1. NC_007530.2. YP_026336.1. NC_005945.1.
3D structure databases
ProteinModelPortal	Q81VZ0.
SMR	Q81VZ0. Positions 2-316.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000011646; EBBACP00000011402; EBBACG00000011638. EBBACT00000017210; EBBACP00000016831; EBBACG00000017201. EBBACT00000022143; EBBACP00000021628; EBBACG00000022134.
GeneID	1084386. 2816256. 2851335.
GenomeReviews	Gene locus BA_0049 in contig AE016879_GR. Gene locus BAS0049 in contig AE017225_GR. Gene locus GBAA_0049 in contig AE017334_GR.
KEGG	ban:BA_0049. bar:GBAA_0049. bat:BAS0049.
TIGR	BA_0049. GBAA_0049.
Phylogenomic databases
GeneTree	EBGT00050000003045.
HOGENOM	HBG519284.
OMA	CATHAVF.
ProtClustDB	PRK01259.
Enzyme and pathway databases
BioCyc	BANT260799:BAS0049-MONOMER. BANT261594:GBAA0049-MONOMER.
Family and domain databases
HAMAP	MF_00583_B. RibP_PPkinase_B. [Tree]
InterPro	IPR000842. PRib_PP_synth_CS. IPR000836. PRibTrfase. IPR005946. Rib-P_diPkinase. [Graphical view]
KO	K00948.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. RibP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPRS_BACAN

Accession

Primary (citable) accession number: Q81VZ0
Secondary accession number(s): Q6I4Z4, Q6KYN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents