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Protein

Hypoxanthine phosphoribosyltransferase

Gene

hprT

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine phosphoribosyltransferase (hpt2), Hypoxanthine phosphoribosyltransferase (A9486_14305), Hypoxanthine phosphoribosyltransferase (A9486_05730), Hypoxanthine phosphoribosyltransferase (BEU23_00345), Hypoxanthine phosphoribosyltransferase (BVG01_16050), Hypoxanthine phosphoribosyltransferase (MCCC1A01412_15175), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hprT)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
Biological processPurine salvageUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Gene namesi
Name:hprTImported
Synonyms:tilSImported
ORF Names:BASH2_00187Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H83X-ray2.06A/B/C/D1-180[»]
SMRiQ81VX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGV. Bacteria.
COG0634. LUCA.
KOiK00760.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
InterProiView protein in InterPro
IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81VX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNQDIEKVL ISEEQIQEKV LELGAIIAED YKNTVPLAIG VLKGAMPFMA
60 70 80 90 100
DLLKRTDTYL EMDFMAVSSY GHSTVSTGEV KILKDLDTSV EGRDILIVED
110 120 130 140 150
IIDSGLTLSY LVDLFKYRKA KSVKIVTLLD KPTGRKVDLK ADYVGFTVPH
160 170 180
EFVVGYGLDY KEQYRNLPYV GVLKPSVYSN
Length:180
Mass (Da):20,208
Last modified:June 1, 2003 - v1
Checksum:i5A34CE2B632D3566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP014833 Genomic DNA. Translation: BAR73594.1.
RefSeqiWP_000981838.1. NZ_MVOA01000002.1.

Genome annotation databases

EnsemblBacteriaiANH84494; ANH84494; A8C77_00370.
KLV14471; KLV14471; ABW01_27435.
KEGGibanh:HYU01_00365.
PATRICifig|1392.230.peg.63.

Similar proteinsi

Entry informationi

Entry nameiQ81VX6_BACAN
AccessioniPrimary (citable) accession number: Q81VX6
Secondary accession number(s): E9R985, Q6I4Y0, Q6KYM4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources