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Protein

Alanine racemase

Gene

dal1

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (MCCC1A01412_22815), Alanine racemase (BEU23_13255), Alanine racemase (A9486_10150), Alanine racemase (ABW01_07145), Alanine racemase (A9486_20715), Alanine racemase (BEU23_26720), Alanine racemase (dal1), Alanine racemase (BVG01_28400), Alanine racemase (dal2), Alanine racemase (BVG01_05295), Alanine racemase (MCCC1A01412_14175)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Active sitei270Proton acceptor; specific for L-alanineUniRule annotation1
Metal bindingi306Magnesium; via carbonyl oxygenCombined sources1
Binding sitei317Substrate; via amide nitrogenUniRule annotation1
Metal bindingi342MagnesiumCombined sources1
Metal bindingi343MagnesiumCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandMagnesiumCombined sources, Metal-bindingCombined sources, Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BRENDAi5.1.1.1. 634.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:dal1Imported
Synonyms:alrImported
Ordered Locus Names:GBAA_0252Imported
ORF Names:BASH2_00003Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-(pyridoxal phosphate)lysineUniRule annotationCombined sources1

Interactioni

Protein-protein interaction databases

IntActiQ81VF6. 3 interactors.
STRINGi260799.BAS0238.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VD8X-ray1.47A/B1-389[»]
2VD9X-ray2.10A/B1-389[»]
3HA1X-ray1.95A/B1-389[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 374Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81VF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAPFYRDT WVEVDLDAIY NNVTHIKEFI PSDVEIFAVV KGNAYGHDYV
60 70 80 90 100
PVAKIALEAG ATRLAVAFLD EALVLRRAGI TAPILVLGPS PPRDINVAAE
110 120 130 140 150
NDVALTVFQK EWVDEAIKLW DGSSTMKYHI NFDSGMGRIG IRERKELKGF
160 170 180 190 200
LKSLEGAPFL ELEGVYTHFA TADEVETSYF DKQYNTFLEQ LSWLKEFGVD
210 220 230 240 250
PKFVHTANSA ATLRFQGITF NAVRIGIAMY GLSPSVEIRP FLPFKLEPAL
260 270 280 290 300
SLHTKVAHIK QVIKGDGISY NVTYRTKTEE WIATVAIGYA DGWLRRLQGF
310 320 330 340 350
EVLVNGKRVP IVGRVTMDQF MIHLPCEVPL GTKVTLIGRQ GDEYISATEV
360 370 380
AEYSGTINYE IITTISFRVP RIFIRNGKVV EVINYLNDI
Length:389
Mass (Da):43,662
Last modified:June 1, 2003 - v1
Checksum:i5B55B2C4920D6BA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT29333.1.
AP014833 Genomic DNA. Translation: BAR73410.1.
RefSeqiWP_000390596.1. NZ_MVOA01000002.1.

Genome annotation databases

EnsemblBacteriaiAAT29333; AAT29333; GBAA_0252.
ANH84668; ANH84668; A8C77_01350.
KEGGibanh:HYU01_01340.
bar:GBAA_0252.
PATRICifig|1392.230.peg.248.

Similar proteinsi

Entry informationi

Entry nameiQ81VF6_BACAN
AccessioniPrimary (citable) accession number: Q81VF6
Secondary accession number(s): E9R9C7
, E9R9C8, Q6I4F7, Q6KY59
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported