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Protein

Alanine racemase

Gene

dal1

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (dal2), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (dal1), Alanine racemase (BVG01_28400), Alanine racemase (alr), Alanine racemase (ABW01_07145), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (MCCC1A01412_22815), Alanine racemase (A9486_10150), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (dal2), Alanine racemase (alr), Alanine racemase (BVG01_05295), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Active sitei270Proton acceptor; specific for L-alanineUniRule annotation1
Metal bindingi306Magnesium; via carbonyl oxygenCombined sources1
Binding sitei317Substrate; via amide nitrogenUniRule annotation1
Metal bindingi342MagnesiumCombined sources1
Metal bindingi343MagnesiumCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandMagnesiumCombined sources, Metal-bindingCombined sources, Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BRENDAi5.1.1.1 634
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:dal1Imported
Ordered Locus Names:GBAA_0252Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-(pyridoxal phosphate)lysineUniRule annotationCombined sources1

Interactioni

Protein-protein interaction databases

IntActiQ81VF6, 3 interactors
STRINGi260799.BAS0238

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VD8X-ray1.47A/B1-389[»]
2VD9X-ray2.10A/B1-389[»]
3HA1X-ray1.95A/B1-389[»]
SMRiQ81VF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q81VF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAPFYRDT WVEVDLDAIY NNVTHIKEFI PSDVEIFAVV KGNAYGHDYV
60 70 80 90 100
PVAKIALEAG ATRLAVAFLD EALVLRRAGI TAPILVLGPS PPRDINVAAE
110 120 130 140 150
NDVALTVFQK EWVDEAIKLW DGSSTMKYHI NFDSGMGRIG IRERKELKGF
160 170 180 190 200
LKSLEGAPFL ELEGVYTHFA TADEVETSYF DKQYNTFLEQ LSWLKEFGVD
210 220 230 240 250
PKFVHTANSA ATLRFQGITF NAVRIGIAMY GLSPSVEIRP FLPFKLEPAL
260 270 280 290 300
SLHTKVAHIK QVIKGDGISY NVTYRTKTEE WIATVAIGYA DGWLRRLQGF
310 320 330 340 350
EVLVNGKRVP IVGRVTMDQF MIHLPCEVPL GTKVTLIGRQ GDEYISATEV
360 370 380
AEYSGTINYE IITTISFRVP RIFIRNGKVV EVINYLNDI
Length:389
Mass (Da):43,662
Last modified:June 1, 2003 - v1
Checksum:i5B55B2C4920D6BA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA Translation: AAT29333.1
RefSeqiWP_000390596.1, NZ_PPES01000019.1

Genome annotation databases

EnsemblBacteriaiAAT29333; AAT29333; GBAA_0252
ANH84668; ANH84668; A8C77_01350
KEGGibanh:HYU01_01340
bar:GBAA_0252
PATRICifig|1392.230.peg.248

Similar proteinsi

Entry informationi

Entry nameiQ81VF6_BACAN
AccessioniPrimary (citable) accession number: Q81VF6
Secondary accession number(s): E9R9C7
, E9R9C8, Q6I4F7, Q6KY59
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health